Construction of Nicotinamide Mononucleotide-Loaded Liposomes and Their In Vitro Transport Across the Blood–Brain Barrier

Construction of Nicotinamide Mononucleotide-Loaded Liposomes and Their In Vitro Transport Across the Blood–Brain Barrier

Nicotinamide mononucleotide (NMN) possesses a variety of physiological functions and has therapeutic effects on cardio-cerebral diseases, senile degenerative diseases, neurodegenerative diseases, delayed aging, etc. However, its ability to cross the blood–brain barrier (BBB) and the mechanism of its...

Full description

Saved in:

Bibliographic Details
Main Authors:	Tiantian Wang, Qi Wu, Lihong Wang, Tao Lan, Zhenyu Yun, Lin Zhao, Xi Wu
Format:	Article
Language:	English
Published:	MDPI AG 2024-12-01
Series:	Applied Sciences
Subjects:	in vitro blood–brain barrier NMN liposome <i>P<sub>app</sub></i> value transport mechanism
Online Access:	https://www.mdpi.com/2076-3417/14/24/11732
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Nicotinamide Mononucleotide Alleviates Bile Acid Metabolism and Hormonal Dysregulation in Letrozole-Induced PCOS Mice
by: Caifang Ren, et al.
Published: (2024-12-01)

Determination of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in plant foods: exploring dietary sources
by: Gabriela Fabiana Soares Alegre, et al.
Published: (2025-12-01)

Nicotinamide mononucleotide alleviates endotoxin-induced acute lung injury by modulating macrophage polarization via the SIRT1/NF-κB pathway
by: Simeng He, et al.
Published: (2024-12-01)

Nicotinamide Mononucleotide Restores NAD<sup>+</sup> Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells
by: Mehboob Ahmed, et al.
Published: (2024-12-01)

Nicotinamide mononucleotide biosynthesis and the F-actin cytoskeleton regulate spindle assembly and oocyte maturation quality in post-ovulatory aged porcine oocytes
by: Hyo-Jin Park, et al.
Published: (2025-04-01)

Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD+/SIRT3 signaling pathway-mediated mitochondrial autophagy to delay skin aging
by: Zixuan Sun, et al.
Published: (2025-07-01)

Nicotinamide mononucleotide combined with PJ-34 protects microglial cells from lipopolysaccharide-induced mitochondrial impairment through NMNAT3-PARP1 axis
by: Jia Li, et al.
Published: (2025-03-01)

Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling
by: Hong Zhou, et al.
Published: (2025-04-01)

A Comprehensive Review of Silymarin Extraction and Liposomal Encapsulation Techniques for Potential Applications in Food
by: Sina Makouie, et al.
Published: (2024-09-01)

NMN reverses D-galactose-induced neurodegeneration and enhances the intestinal barrier of mice by activating the Sirt1 pathway
by: Yuxian Lin, et al.
Published: (2025-04-01)

Dietary Nicotinamide Mononucleotide, a Key NAD<sup>+</sup> Intermediate, Alleviates Body Fat Mass and Hypertriglyceridemia by Enhancing Energy Expenditure with Promotion of Fat Oxidation and Hepatic Lipolysis and Suppressing Hepatic Lipogenesis in <i>db/db</i> Mice
by: Bungo Shirouchi, et al.
Published: (2025-05-01)

Commutators of Pre-Lie <i>n</i>-Algebras and <i>PL</i><sub>∞</sub>-Algebras
by: Mengjun Wang, et al.
Published: (2025-05-01)

Identical Neighbor Structure: Effects on Spectrum and Independence in <i>CN</i><sub>s</sub> Cartesian Product of Graphs
by: Subha A B, et al.
Published: (2025-03-01)

Сomplex doping niobium oxide with ionic conductivity.
by: V. V. Konovalova, et al.
Published: (2009-08-01)

Anchoring and Catalytic Performance of Co@C<sub>2</sub>N Monolayer for Rechargeable Li-Se<i><sub>x</sub></i>S<i><sub>y</sub></i> Batteries: A First-Principles Calculations
by: Xiaojing Li, et al.
Published: (2024-11-01)

Study on Ozone and Its Critical Influencing Factors in Key Regions of China
by: Zhenhai Wu, et al.
Published: (2024-11-01)

Whole Genome Analysis of <i>Proteus mirabilis</i> in a Poultry Breeder Farm Reveals the Dissemination of <i>bla</i><sub>NDM</sub> and <i>bla</i><sub>CTX-M</sub> Mediated by Diverse Mobile Genetic Elements
by: Haibin Hu, et al.
Published: (2025-03-01)

The Effects of Cutting Parameters on Cutting Force and Tribological Properties of Machined Surface Under Dry Turning of AISI304L Austenitic Stainless Steel
by: Gábor Kónya, et al.
Published: (2024-11-01)

Vanadium-Based MXenes: Types, Synthesis, and Recent Advances in Supercapacitor Applications
by: Zhiwei Gao, et al.
Published: (2025-07-01)

Elevated Cellular Uptake of Succinimide- and Glucose-Modified Liposomes for Blood–Brain Barrier Transfer and Glioblastoma Therapy
by: Larissa J. Lubitz, et al.
Published: (2024-09-01)

Development and Transportation Pathway Evaluation of Liposomes with Bile Acids for Enhancing the Blood-Brain Barrier Penetration of Methotrexate
by: Natthan Charernsriwilaiwat, et al.
Published: (2025-02-01)

Nicotinamide mononucleotide boosts the development of bovine oocyte by enhancing mitochondrial function and reducing chromosome lagging
by: Shu Hashimoto, et al.
Published: (2025-01-01)

The Barrier Inhomogeneity and the Electrical Characteristics of W/Au <i>β</i>-Ga<sub>2</sub>O<sub>3</sub> Schottky Barrier Diodes
by: Lei Xie, et al.
Published: (2025-03-01)

Nanosecond Breakdown Characteristics of <i>C</i><sub>4</sub><i>F</i><sub>7</sub><i>N</i> and Various Mixtures at Pressures Above 1 Atmosphere in Comparison with <i>SF</i><sub>6</sub>
by: Luke Silvestre, et al.
Published: (2024-12-01)

Interaction of Liposomes Containing the Carrageenan/Echinochrome Complex with Human HaCaT Keratinocytes In Vitro
by: Ekaterina S. Menchinskaya, et al.
Published: (2024-12-01)

Essential Norm of Products of Volterra-Type Operators and Composition Operators on Iterated Banach-Type Spaces
by: Rabab Alyusof, et al.
Published: (2025-05-01)

Biosynthesis and Characterization of Mn<sub>3</sub>O<sub>4</sub> Nanoparticles Using <i>Bixa orellana</i> and <i>Nerium oleander</i> Leaf Extracts at Low Temperature and Neutral pH
by: Eiser Valle-Rivera, et al.
Published: (2025-02-01)

Effects of Hall Current and Thermal Radiation on the Time-Dependent Swirling Flow of Hybrid Nanofluids over a Disk Surface: A Bayesian Regularization Artificial Neural Network Approach
by: Faisal Nazir, et al.
Published: (2024-12-01)

Integrative Transcriptomics and Metabolomics Reveal the Key Metabolic Pathways in Endophyte-Infected Rice Seedlings Resistance to Na<sub>2</sub>CO<sub>3</sub> Stress
by: Xinnan Wang, et al.
Published: (2025-05-01)

Predicting Remaining Useful Life of Induction Motor Bearings from Motor Current Signatures Using Machine Learning
by: Nurul Zahirah Zulkifli, et al.
Published: (2025-05-01)

N-Methods
by: Ahu Açikgöz, et al.
Published: (2025-05-01)

Modeling and Control of Tugboat-Assisted Operation for Marine Vessels
by: Jung-Suk Park, et al.
Published: (2025-04-01)

Electrostatic Self-Assembly of Heterostructured In<sub>2</sub>O<sub>3</sub>/Ti<sub>3</sub>C<sub>2</sub>T<i><sub>x</sub></i> Nanocomposite for High-Selectivity NO<sub>2</sub> Gas Sensing at Room Temperature
by: Yongjing Guo, et al.
Published: (2025-07-01)

Physicochemical Characterization of Kynurenine Pathway Metabolites
by: Luca Buzásy, et al.
Published: (2025-05-01)

Growth and Characterization of Ga<sub>2</sub>O<sub>3</sub> for Power Nanodevices Using Metal Nanoparticle Catalysts
by: Badriyah Alhalaili, et al.
Published: (2025-07-01)

Feasibility of Organic Fertilization for Reducing Greenhouse Gas Emissions Compared to Mineral Fertilization
by: Sirio Douglas da Silva dos Reis, et al.
Published: (2025-06-01)

The Effect of Specific Treadmill Protocol on Aerobic Performance Parameters in Flat-Terrain-Trained Athletes
by: Ming-Chang Tsai, et al.
Published: (2025-04-01)

Emergent Plants Improve Nitrogen Uptake Rates by Regulating the Activity of Nitrogen Assimilation Enzymes
by: Yu Hong, et al.
Published: (2025-05-01)

Comparative Genomic and Transcriptomic Analysis Provides New Insights into the Aflatoxin B<sub>1</sub> Biodegradability by <i>Kocuria rosea</i> from Deep Sea
by: Jingying Wang, et al.
Published: (2025-04-01)

Liposome-Based Encapsulation of Extract from Wild Thyme (<i>Thymus serpyllum</i> L.) Tea Processing Residues for Delivery of Polyphenols
by: Aleksandra A. Jovanović, et al.
Published: (2025-07-01)