Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation

Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation

ABSTRACT Background The PI3K/Akt/mTOR signaling pathway is commonly deregulated in different types of cancers, contributing to tumor proliferation, persistence, and resistance to treatment. Akt1, a crucial kinase within this pathway, plays a critical role in tumor progression and the occurrence of t...

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Bibliographic Details
Main Authors: Shokoofeh Jamshidi, Ali Eghbalian, Setareh Shojaei, Amir Taherkhani, Mehran Feizi‐Dehnayebi
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Cancer Reports
Subjects:
Akt1
cancer
drug
flavonoid
molecular docking
Online Access:https://doi.org/10.1002/cnr2.70315
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