Host-Bacteria Crosstalk at the Dentogingival Junction
The dentogingival junction is of crucial importance in periodontal host defense both structurally and functionally. Oral bacteria exert a constant challenge to the host cells and tissues at the dentogingival junction. The host response is set up to eliminate the pathogens by the innate and adaptive...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2012/821383 |
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| author | M. T. Pöllänen M. A. Laine R. Ihalin V.-J. Uitto |
| author_facet | M. T. Pöllänen M. A. Laine R. Ihalin V.-J. Uitto |
| author_sort | M. T. Pöllänen |
| collection | DOAJ |
| description | The dentogingival junction is of crucial importance in periodontal host defense both structurally and functionally. Oral bacteria exert a constant challenge to the host cells and tissues at the dentogingival junction. The host response is set up to eliminate the pathogens by the innate and adaptive defense mechanisms. In health, the commensal bacteria and the host defense mechanisms are in a dynamic steady state. During periodontal disease progression, the dental bacterial plaque, junctional epithelium (JE), inflammatory cells, connective tissue, and bone all go through a series of changes. The tissue homeostasis is turned into tissue destruction and progression of periodontitis. The classical study of Slots showed that in the bacterial plaque, the most remarkable change is the shift from gram-positive aerobic and facultatively anaerobic flora to a predominantly gram-negative and anaerobic flora. This has been later confirmed by several other studies. Furthermore, not only the shift of the bacterial flora to a more pathogenic one, but also bacterial growth as a biofilm on the tooth surface, allows the bacteria to communicate with each other and exert their virulence aimed at favoring their growth. This paper focuses on host-bacteria crosstalk at the dentogingival junction and the models studying it in vitro. |
| format | Article |
| id | doaj-art-b3230501a3d04ee8bdf94e948dcf7336 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-b3230501a3d04ee8bdf94e948dcf73362025-02-03T05:47:10ZengWileyInternational Journal of Dentistry1687-87281687-87362012-01-01201210.1155/2012/821383821383Host-Bacteria Crosstalk at the Dentogingival JunctionM. T. Pöllänen0M. A. Laine1R. Ihalin2V.-J. Uitto3Department of Periodontology, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520 Turku, FinlandDepartment of Cariology, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520 Turku, FinlandDepartment of Biochemistry and Food Chemistry, University of Turku, 20520 Turku, FinlandDepartment of Periodontology, Institute of Dentistry, University of Helsinki, 00014 Helsinki, FinlandThe dentogingival junction is of crucial importance in periodontal host defense both structurally and functionally. Oral bacteria exert a constant challenge to the host cells and tissues at the dentogingival junction. The host response is set up to eliminate the pathogens by the innate and adaptive defense mechanisms. In health, the commensal bacteria and the host defense mechanisms are in a dynamic steady state. During periodontal disease progression, the dental bacterial plaque, junctional epithelium (JE), inflammatory cells, connective tissue, and bone all go through a series of changes. The tissue homeostasis is turned into tissue destruction and progression of periodontitis. The classical study of Slots showed that in the bacterial plaque, the most remarkable change is the shift from gram-positive aerobic and facultatively anaerobic flora to a predominantly gram-negative and anaerobic flora. This has been later confirmed by several other studies. Furthermore, not only the shift of the bacterial flora to a more pathogenic one, but also bacterial growth as a biofilm on the tooth surface, allows the bacteria to communicate with each other and exert their virulence aimed at favoring their growth. This paper focuses on host-bacteria crosstalk at the dentogingival junction and the models studying it in vitro.http://dx.doi.org/10.1155/2012/821383 |
| spellingShingle | M. T. Pöllänen M. A. Laine R. Ihalin V.-J. Uitto Host-Bacteria Crosstalk at the Dentogingival Junction International Journal of Dentistry |
| title | Host-Bacteria Crosstalk at the Dentogingival Junction |
| title_full | Host-Bacteria Crosstalk at the Dentogingival Junction |
| title_fullStr | Host-Bacteria Crosstalk at the Dentogingival Junction |
| title_full_unstemmed | Host-Bacteria Crosstalk at the Dentogingival Junction |
| title_short | Host-Bacteria Crosstalk at the Dentogingival Junction |
| title_sort | host bacteria crosstalk at the dentogingival junction |
| url | http://dx.doi.org/10.1155/2012/821383 |
| work_keys_str_mv | AT mtpollanen hostbacteriacrosstalkatthedentogingivaljunction AT malaine hostbacteriacrosstalkatthedentogingivaljunction AT rihalin hostbacteriacrosstalkatthedentogingivaljunction AT vjuitto hostbacteriacrosstalkatthedentogingivaljunction |