THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT
Parathyroid carcinoma (PC) is a rare neoplasm with a prevalence of only 0.005 % of all malignancies, and less than 1 % among patients with primary hyperparathyroidism. The diagnosis can be challenging due to the rarity of the disease, similarity of clinical features to parathyroid adenoma, and lack...
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2017-04-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/254 |
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| author | V. A. Gorbunova E. A. Pigarova L. Ya. Rozhinskaya I. A. Voronkova Yu. A. Krupinova G. S. Emel’yanova L. S. Kruglova S. V. Shiryaev M. B. Dolgushin M. E. Bilik E. A. Kobyakova D. V. Komov |
| author_facet | V. A. Gorbunova E. A. Pigarova L. Ya. Rozhinskaya I. A. Voronkova Yu. A. Krupinova G. S. Emel’yanova L. S. Kruglova S. V. Shiryaev M. B. Dolgushin M. E. Bilik E. A. Kobyakova D. V. Komov |
| author_sort | V. A. Gorbunova |
| collection | DOAJ |
| description | Parathyroid carcinoma (PC) is a rare neoplasm with a prevalence of only 0.005 % of all malignancies, and less than 1 % among patients with primary hyperparathyroidism. The diagnosis can be challenging due to the rarity of the disease, similarity of clinical features to parathyroid adenoma, and lack of reliable morphological signs of the tumor. For metastatic cancer of the parathyroid gland does not exist standard drug therapy due to the rare occurrence of this disease. Chemotherapy and radiotherapy failed to show any significant effect on the course of the disease. We report the case of a 27-year old woman with PC previously misdiagnosed as benign thyroid nodule and multiple lung metastases. After the immunohistochemical study and confirm of diagnosis PC the patient was treatment with multikinase inhibitor sorafenib successfully. |
| format | Article |
| id | doaj-art-b2fd305b5ebd4dea8aed2c9bc3b0ae32 |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2017-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-b2fd305b5ebd4dea8aed2c9bc3b0ae322025-08-20T04:00:19ZrusABV-pressОпухоли головы и шеи2222-14682411-46342017-04-0164677210.17650/2222-1468-2016-6-4-67-72239THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORTV. A. Gorbunova0E. A. Pigarova1L. Ya. Rozhinskaya2I. A. Voronkova3Yu. A. Krupinova4G. S. Emel’yanova5L. S. Kruglova6S. V. Shiryaev7M. B. Dolgushin8M. E. Bilik9E. A. Kobyakova10D. V. Komov11N.N. Blokhin Russian Cancer Research CenterEndocrinology Research CenterEndocrinology Research CenterEndocrinology Research CenterEndocrinology Research CenterA.I. Evdokimov Moscow State University of Medicine and DentistryCentral State Medical AcademyN.N. Blokhin Russian Cancer Research CenterN.N. Blokhin Russian Cancer Research CenterN.N. Blokhin Russian Cancer Research CenterN.N. Blokhin Russian Cancer Research CenterN.N. Blokhin Russian Cancer Research CenterParathyroid carcinoma (PC) is a rare neoplasm with a prevalence of only 0.005 % of all malignancies, and less than 1 % among patients with primary hyperparathyroidism. The diagnosis can be challenging due to the rarity of the disease, similarity of clinical features to parathyroid adenoma, and lack of reliable morphological signs of the tumor. For metastatic cancer of the parathyroid gland does not exist standard drug therapy due to the rare occurrence of this disease. Chemotherapy and radiotherapy failed to show any significant effect on the course of the disease. We report the case of a 27-year old woman with PC previously misdiagnosed as benign thyroid nodule and multiple lung metastases. After the immunohistochemical study and confirm of diagnosis PC the patient was treatment with multikinase inhibitor sorafenib successfully.https://ogsh.abvpress.ru/jour/article/view/254parathyroid carcinomalung metastasesprimary hyperparathyroidismhypercalcemiamultikinase inhibitorssorafenib |
| spellingShingle | V. A. Gorbunova E. A. Pigarova L. Ya. Rozhinskaya I. A. Voronkova Yu. A. Krupinova G. S. Emel’yanova L. S. Kruglova S. V. Shiryaev M. B. Dolgushin M. E. Bilik E. A. Kobyakova D. V. Komov THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT Опухоли головы и шеи parathyroid carcinoma lung metastases primary hyperparathyroidism hypercalcemia multikinase inhibitors sorafenib |
| title | THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT |
| title_full | THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT |
| title_fullStr | THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT |
| title_full_unstemmed | THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT |
| title_short | THE USE OF SORAFENIB (NEXAVAR) IN TREATMENT OF PATIENT WITH DISSEMINATED PARATHYROID CANCER: A CASE REPORT |
| title_sort | use of sorafenib nexavar in treatment of patient with disseminated parathyroid cancer a case report |
| topic | parathyroid carcinoma lung metastases primary hyperparathyroidism hypercalcemia multikinase inhibitors sorafenib |
| url | https://ogsh.abvpress.ru/jour/article/view/254 |
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