Lentinan enhances CAR-T cell potency in solid tumors by optimizing T cell differentiation

Lentinan enhances CAR-T cell potency in solid tumors by optimizing T cell differentiation

CAR-T cell therapy has demonstrated remarkable success in treating hematologic malignancies; however, its efficacy in solid tumors remains constrained. In this study, we demonstrate that Lentinan (LTN), an active polysaccharide derived from Lentinula edodes, potently enhances CAR-T cell function aga...

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Bibliographic Details
Main Authors: Xiangyun Niu, Pengchao Zhang, Zhongming Liu, Yexiao Tang, Shu Xu, Xiaochun Wan, Zhiming Xu, Guizhong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
CAR-T cell therapy
lentinan
central memory T cells
solid tumor
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605488/full
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