Pseudo-precocious puberty secondary to Juvenile Granulosa cell tumour in a 30-month-old female toddler: A case report
Background: Precocious puberty is rare globally and its incidence in Nigeria is unknown, as few reported cases exist. Case presentation: We report a 30-month-old female toddler with abnormal vaginal bleeding and breast enlargement of three months duration, with associated pubic and axillary hair....
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Babcock Medical Society
2024-12-01
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| Series: | Babcock University Medical Journal |
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| Online Access: | http://bumj.babcock.edu.ng/index.php/bumj/article/view/560 |
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| author | Taiwo Oni Adesola Adekoya Grillo Elizabeth John Nwadiokwu Victor Okebalama Oluwaseun Anifowose |
| author_facet | Taiwo Oni Adesola Adekoya Grillo Elizabeth John Nwadiokwu Victor Okebalama Oluwaseun Anifowose |
| author_sort | Taiwo Oni |
| collection | DOAJ |
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Background: Precocious puberty is rare globally and its incidence in Nigeria is unknown, as few reported cases exist.
Case presentation: We report a 30-month-old female toddler with abnormal vaginal bleeding and breast enlargement of three months duration, with associated pubic and axillary hair. Height increase and unusual temper tantrums were also noticed. She had a 2-year history of steroid-containing cream use. The unrelated parents had normal puberty. There was no similar history in the siblings.
Her height was 94 cm (97th centile) and weighed 12 kg (50th centile). There were no café-au-lait spots. Breast development and pubic hair both corresponded to Tanner Stage 2. A firm mass was palpated in the lower abdominal region. A pelvic magnetic resonance imaging scan revealed a round heterogenous mass with multiple focal cystic areas in the left pelvic cavity. Bone age was normal.
Serial oestradiol levels were elevated. Tumor markers were within normal ranges. The cytological analysis of excised tissues during exploratory laparotomy with left oophorectomy revealed Call-Exner bodies which are pathognomonic for granulosa cell tumours. She has remained stable after the surgery.
Discussion and conclusion: This case report highlights the importance of considering and investigating rare causes of pseudo-precocious puberty in pre-pubertal girls.
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| format | Article |
| id | doaj-art-b2d5840af3b44e30a8212e3ab6c3f250 |
| institution | Kabale University |
| issn | 2465-6666 2756-4657 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Babcock Medical Society |
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| series | Babcock University Medical Journal |
| spelling | doaj-art-b2d5840af3b44e30a8212e3ab6c3f2502025-01-05T18:31:33ZengBabcock Medical SocietyBabcock University Medical Journal2465-66662756-46572024-12-017210.38029/babcockuniv.med.j..v7i2.560Pseudo-precocious puberty secondary to Juvenile Granulosa cell tumour in a 30-month-old female toddler: A case reportTaiwo Oni0Adesola Adekoya1Grillo Elizabeth2John Nwadiokwu3Victor Okebalama4Oluwaseun Anifowose5Department of Paediatrics, Babcock University Teaching Hospital, Ilishan-Remo, Ogun State, NigeriaDepartment of Paediatrics, Babcock University Teaching Hospital, Ilishan-Remo, Ogun State, NigeriaDepartment of Obstetrics and Gynaecology, Babcock University Teaching Hospital, Ilishan-Remo, Ogun State, NigeriaDepartment of Anatomic Pathology, Babcock University Teaching Hospital, Ilishan-Remo, Ogun State, NigeriaDepartment of Anatomic Pathology, Babcock University Teaching Hospital, Ilishan-Remo, Ogun State, NigeriaDepartment of Radiology, Babcock University Teaching Hospital, Ilishan-Remo, Ogun State, Nigeria Background: Precocious puberty is rare globally and its incidence in Nigeria is unknown, as few reported cases exist. Case presentation: We report a 30-month-old female toddler with abnormal vaginal bleeding and breast enlargement of three months duration, with associated pubic and axillary hair. Height increase and unusual temper tantrums were also noticed. She had a 2-year history of steroid-containing cream use. The unrelated parents had normal puberty. There was no similar history in the siblings. Her height was 94 cm (97th centile) and weighed 12 kg (50th centile). There were no café-au-lait spots. Breast development and pubic hair both corresponded to Tanner Stage 2. A firm mass was palpated in the lower abdominal region. A pelvic magnetic resonance imaging scan revealed a round heterogenous mass with multiple focal cystic areas in the left pelvic cavity. Bone age was normal. Serial oestradiol levels were elevated. Tumor markers were within normal ranges. The cytological analysis of excised tissues during exploratory laparotomy with left oophorectomy revealed Call-Exner bodies which are pathognomonic for granulosa cell tumours. She has remained stable after the surgery. Discussion and conclusion: This case report highlights the importance of considering and investigating rare causes of pseudo-precocious puberty in pre-pubertal girls. http://bumj.babcock.edu.ng/index.php/bumj/article/view/560FemaleJuvenile granulosa cell tumour Pseudoprecocious pubertyToddler |
| spellingShingle | Taiwo Oni Adesola Adekoya Grillo Elizabeth John Nwadiokwu Victor Okebalama Oluwaseun Anifowose Pseudo-precocious puberty secondary to Juvenile Granulosa cell tumour in a 30-month-old female toddler: A case report Babcock University Medical Journal Female Juvenile granulosa cell tumour Pseudoprecocious puberty Toddler |
| title | Pseudo-precocious puberty secondary to Juvenile Granulosa cell tumour in a 30-month-old female toddler: A case report |
| title_full | Pseudo-precocious puberty secondary to Juvenile Granulosa cell tumour in a 30-month-old female toddler: A case report |
| title_fullStr | Pseudo-precocious puberty secondary to Juvenile Granulosa cell tumour in a 30-month-old female toddler: A case report |
| title_full_unstemmed | Pseudo-precocious puberty secondary to Juvenile Granulosa cell tumour in a 30-month-old female toddler: A case report |
| title_short | Pseudo-precocious puberty secondary to Juvenile Granulosa cell tumour in a 30-month-old female toddler: A case report |
| title_sort | pseudo precocious puberty secondary to juvenile granulosa cell tumour in a 30 month old female toddler a case report |
| topic | Female Juvenile granulosa cell tumour Pseudoprecocious puberty Toddler |
| url | http://bumj.babcock.edu.ng/index.php/bumj/article/view/560 |
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