Evaluation of the effects of increasing doses of meloxicam on hematological, biochemical and hemostatic blood parameters in sheep
<b>Aim: </b>The aim of the study was to determine the effect of intravenous administration of meloxicam at increasing doses (0.5, 1 and 2 mg/kg) on hematological, biochemical and coagulation parameters in sheep.<p> <b>Materials and Methods: </b>Clinically healthy sheep...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2021-12-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1370 |
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| Summary: | <b>Aim: </b>The aim of the study was to determine the effect of intravenous administration
of meloxicam at increasing doses (0.5, 1 and 2 mg/kg) on hematological,
biochemical and coagulation parameters in sheep.<p>
<b>Materials and Methods: </b>Clinically healthy sheep were randomly divided
into groups as Group 1 (n:6), Group 2 (n:6) and Group 3 (n:6). Meloxicam
was administered intravenously as a single dose of 0,5 mg/kg in Group 1,
1 mg/kg in Group 2 and 2 mg/kg in Group 3. To determine the effect of
increasing single doses of meloxicam on hematological, biochemical and
coagulation factors, blood samples were collected at 0, 24, and 72 hours. In
addition, hemogram (RBC, MCV, MCH, MCHC, HCT, WBC, HGB, RDW, MPV,
PDW, PCT, PLT) and biochemical parameters (AST, ALT, ALP, GGT, TP, UREA,
CREA, CHOL, TRIG, ALB) ) and the levels of coagulation parameters (PT,
APTT, INR, FIB) were determined.<p>
<b>Results: </b>In groups; Differences in biochemical parameters other than
UREA and parameters of RBC, HCT, MCV, MCHC, MPV were statistically significant
(p<0,05). It was observed that there was no statistically significant
difference in terms of their relationship with hemostatic blood parameter
levels.<p>
<b>Conclusion:</b> In conclusion, it is thought that further studies techniques
such as molecular diagnostic methods are needed in terms of hemostatic,
hematological and biochemical effects of increasing single doses of meloxicam
in sheep. |
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| ISSN: | 1309-6958 2146-1953 |