Effect of Baicalein on Cognitive Impairment in Diabetes Mellitus with Cerebral Small Vessel Disease
Objective:To observe whether baicalein have therapeutic value on diabetes mellitus (DM) with cerebral small vessel disease (CSVD) so as to explore the pathogenesis and therapy of the cognitive ability and behavioral function disorder caused by chronic cerebral ischemia and hypoxia.Methods:A total of...
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Editorial Office of Rehabilitation Medicine
2018-02-01
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| Series: | 康复学报 |
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| Online Access: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2018.01024 |
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| author | Li ZHOU Zhengqi LU Xiaoming YE Wanxin YANG Zhisheng WEI Yi KONG Xuming HUANG |
| author_facet | Li ZHOU Zhengqi LU Xiaoming YE Wanxin YANG Zhisheng WEI Yi KONG Xuming HUANG |
| author_sort | Li ZHOU |
| collection | DOAJ |
| description | Objective:To observe whether baicalein have therapeutic value on diabetes mellitus (DM) with cerebral small vessel disease (CSVD) so as to explore the pathogenesis and therapy of the cognitive ability and behavioral function disorder caused by chronic cerebral ischemia and hypoxia.Methods:A total of thirty male SD rats were randomly divided into normal control group, model group and treatment group, 10 rats in each group. After the stable models of DM with CSVD were established, cognitive function scores of all rats were evaluated by Morris water maze test, and the levels of acetylcholine (Ach) and acetylcholinesterase (AchE) in brain were assessed to evaluate the protective effects of baicalein.Results:Morris water maze test showed that learning and memory function had been significantly impaired in rats of DM with CSVD since the 7th day of modeling. Spatial probe test founded that the times of crossing platform in the model group were significantly lower than those in the normal control group (<italic>P</italic><0.05). Compared with the normal control group, the Ach level in the brain homogenate of the model group reduced significantly (<italic>P</italic><0.05), while the AchE level increased significantly (<italic>P</italic><0.05). Compared with the model group, the Ach level in the brain homogenate of the treatment group increased significantly (<italic>P</italic><0.05). The HE staining sections illustrated a large number of active neurons were found in the control group, but loose spongiform degeneration of brain tissue, apoptosis and necrosis of neurons and karyopyknosis were detected in the model group. However, it showed that the learning and memory abilities in the treatment group had improved, while the brain tissue also had been protected.Conclusion:Baicalein has a protective effect on cognitive impairment in diabetes mellitus with cerebral small vessel disease, and it may be a new targeted therapy for this disease. |
| format | Article |
| id | doaj-art-b2bbcf67fb2e449a900cae2aba7591f6 |
| institution | Kabale University |
| issn | 2096-0328 |
| language | English |
| publishDate | 2018-02-01 |
| publisher | Editorial Office of Rehabilitation Medicine |
| record_format | Article |
| series | 康复学报 |
| spelling | doaj-art-b2bbcf67fb2e449a900cae2aba7591f62025-01-14T10:05:20ZengEditorial Office of Rehabilitation Medicine康复学报2096-03282018-02-0128243023126876Effect of Baicalein on Cognitive Impairment in Diabetes Mellitus with Cerebral Small Vessel DiseaseLi ZHOUZhengqi LUXiaoming YEWanxin YANGZhisheng WEIYi KONGXuming HUANGObjective:To observe whether baicalein have therapeutic value on diabetes mellitus (DM) with cerebral small vessel disease (CSVD) so as to explore the pathogenesis and therapy of the cognitive ability and behavioral function disorder caused by chronic cerebral ischemia and hypoxia.Methods:A total of thirty male SD rats were randomly divided into normal control group, model group and treatment group, 10 rats in each group. After the stable models of DM with CSVD were established, cognitive function scores of all rats were evaluated by Morris water maze test, and the levels of acetylcholine (Ach) and acetylcholinesterase (AchE) in brain were assessed to evaluate the protective effects of baicalein.Results:Morris water maze test showed that learning and memory function had been significantly impaired in rats of DM with CSVD since the 7th day of modeling. Spatial probe test founded that the times of crossing platform in the model group were significantly lower than those in the normal control group (<italic>P</italic><0.05). Compared with the normal control group, the Ach level in the brain homogenate of the model group reduced significantly (<italic>P</italic><0.05), while the AchE level increased significantly (<italic>P</italic><0.05). Compared with the model group, the Ach level in the brain homogenate of the treatment group increased significantly (<italic>P</italic><0.05). The HE staining sections illustrated a large number of active neurons were found in the control group, but loose spongiform degeneration of brain tissue, apoptosis and necrosis of neurons and karyopyknosis were detected in the model group. However, it showed that the learning and memory abilities in the treatment group had improved, while the brain tissue also had been protected.Conclusion:Baicalein has a protective effect on cognitive impairment in diabetes mellitus with cerebral small vessel disease, and it may be a new targeted therapy for this disease.http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2018.01024small brain vascular diseasediabetescognitive declinebaicalein |
| spellingShingle | Li ZHOU Zhengqi LU Xiaoming YE Wanxin YANG Zhisheng WEI Yi KONG Xuming HUANG Effect of Baicalein on Cognitive Impairment in Diabetes Mellitus with Cerebral Small Vessel Disease 康复学报 small brain vascular disease diabetes cognitive decline baicalein |
| title | Effect of Baicalein on Cognitive Impairment in Diabetes Mellitus with Cerebral Small Vessel Disease |
| title_full | Effect of Baicalein on Cognitive Impairment in Diabetes Mellitus with Cerebral Small Vessel Disease |
| title_fullStr | Effect of Baicalein on Cognitive Impairment in Diabetes Mellitus with Cerebral Small Vessel Disease |
| title_full_unstemmed | Effect of Baicalein on Cognitive Impairment in Diabetes Mellitus with Cerebral Small Vessel Disease |
| title_short | Effect of Baicalein on Cognitive Impairment in Diabetes Mellitus with Cerebral Small Vessel Disease |
| title_sort | effect of baicalein on cognitive impairment in diabetes mellitus with cerebral small vessel disease |
| topic | small brain vascular disease diabetes cognitive decline baicalein |
| url | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2018.01024 |
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