Radix Codonopsis: a review of anticancer pharmacological activities
Radix Codonopsis (Dangshen), derived from the dried root of plants in the Campanulaceae family, is a widely used Chinese herbal medicine. It is renowned for its pharmacological effects, including tonifying the middle qi, invigorating the spleen, benefiting the lungs, enhancing immunity, and nourishi...
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| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1498707/full |
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| author | Cai-Yue Liu Zheng Li Fan-E. Cheng Yi Nan Yi Nan Wei-Qiang Li Wei-Qiang Li |
| author_facet | Cai-Yue Liu Zheng Li Fan-E. Cheng Yi Nan Yi Nan Wei-Qiang Li Wei-Qiang Li |
| author_sort | Cai-Yue Liu |
| collection | DOAJ |
| description | Radix Codonopsis (Dangshen), derived from the dried root of plants in the Campanulaceae family, is a widely used Chinese herbal medicine. It is renowned for its pharmacological effects, including tonifying the middle qi, invigorating the spleen, benefiting the lungs, enhancing immunity, and nourishing the blood. Codonopsis extract is frequently incorporated into health products such as tablets and capsules, making it accessible for daily health maintenance. Additionally, it is commonly used in dietary applications like soups, teas, and porridges to nourish qi, enrich blood, and promote overall vitality. In recent years, increasing attention has been given to the anti-cancer potential of Radix Codonopsis. Studies have identified key active components such as luteolin, stigmasterol, polyacetylenes, lobetyolin, and glycitein, which exhibit anti-tumor properties through mechanisms like inhibiting cancer cell growth and proliferation, suppressing epithelial-mesenchymal transition (EMT), and inducing apoptosis. This review highlights the research progress on Radix Codonopsis, including its active constituents, anti-cancer mechanisms, and its role in the convergence of medicine and food in modern life. By doing so, it aims to provide valuable insights and references for future scientific studies and clinical applications of Radix Codonopsis. |
| format | Article |
| id | doaj-art-b2919f5ca95c46359618787b4a7e3b5d |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-b2919f5ca95c46359618787b4a7e3b5d2025-01-07T06:49:34ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14987071498707Radix Codonopsis: a review of anticancer pharmacological activitiesCai-Yue Liu0Zheng Li1Fan-E. Cheng2Yi Nan3Yi Nan4Wei-Qiang Li5Wei-Qiang Li6Ningxia Medical University, Ningxia of Traditional Chinese Medicine, Yinchuan, ChinaNingxia Medical University, Ningxia of Traditional Chinese Medicine, Yinchuan, ChinaNingxia Medical University, Ningxia of Traditional Chinese Medicine, Yinchuan, ChinaNingxia Medical University, Ningxia of Traditional Chinese Medicine, Yinchuan, ChinaKey Laboratory of Ningxia Minority Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, ChinaNingxia Medical University, Ningxia of Traditional Chinese Medicine, Yinchuan, ChinaKey Laboratory of Ningxia Minority Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, ChinaRadix Codonopsis (Dangshen), derived from the dried root of plants in the Campanulaceae family, is a widely used Chinese herbal medicine. It is renowned for its pharmacological effects, including tonifying the middle qi, invigorating the spleen, benefiting the lungs, enhancing immunity, and nourishing the blood. Codonopsis extract is frequently incorporated into health products such as tablets and capsules, making it accessible for daily health maintenance. Additionally, it is commonly used in dietary applications like soups, teas, and porridges to nourish qi, enrich blood, and promote overall vitality. In recent years, increasing attention has been given to the anti-cancer potential of Radix Codonopsis. Studies have identified key active components such as luteolin, stigmasterol, polyacetylenes, lobetyolin, and glycitein, which exhibit anti-tumor properties through mechanisms like inhibiting cancer cell growth and proliferation, suppressing epithelial-mesenchymal transition (EMT), and inducing apoptosis. This review highlights the research progress on Radix Codonopsis, including its active constituents, anti-cancer mechanisms, and its role in the convergence of medicine and food in modern life. By doing so, it aims to provide valuable insights and references for future scientific studies and clinical applications of Radix Codonopsis.https://www.frontiersin.org/articles/10.3389/fphar.2024.1498707/fullRadix Codonopsistumortraditional Chinese medicinemechanismpharmacology |
| spellingShingle | Cai-Yue Liu Zheng Li Fan-E. Cheng Yi Nan Yi Nan Wei-Qiang Li Wei-Qiang Li Radix Codonopsis: a review of anticancer pharmacological activities Frontiers in Pharmacology Radix Codonopsis tumor traditional Chinese medicine mechanism pharmacology |
| title | Radix Codonopsis: a review of anticancer pharmacological activities |
| title_full | Radix Codonopsis: a review of anticancer pharmacological activities |
| title_fullStr | Radix Codonopsis: a review of anticancer pharmacological activities |
| title_full_unstemmed | Radix Codonopsis: a review of anticancer pharmacological activities |
| title_short | Radix Codonopsis: a review of anticancer pharmacological activities |
| title_sort | radix codonopsis a review of anticancer pharmacological activities |
| topic | Radix Codonopsis tumor traditional Chinese medicine mechanism pharmacology |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1498707/full |
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