Higher-Order DNA Secondary Structures and Their Transformations: The Hidden Complexities of Tetrad and Quadruplex DNA Structures, Complexes, and Modulatory Interactions Induced by Strand Invasion Events

Higher-Order DNA Secondary Structures and Their Transformations: The Hidden Complexities of Tetrad and Quadruplex DNA Structures, Complexes, and Modulatory Interactions Induced by Strand Invasion Events

We demonstrate that a short oligonucleotide complementary to a G-quadruplex domain can invade this iconic, noncanonical DNA secondary structure in ways that profoundly influence the properties and differential occupancies of the resulting DNA polymorphic products. Our spectroscopic mapping of the co...

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Bibliographic Details
Main Authors: Jens Völker, Vera Gindikin, Kenneth J. Breslauer
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
DNA strand invasion
metastable DNA states
G-quadruplex/iDNA/duplex interconversions
rough energy landscapes
competing kinetic and thermodynamic states
coupled transformations of higher-order DNA states
Online Access:https://www.mdpi.com/2218-273X/14/12/1532
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