Batzelladine D, a Marine Natural Product, Reverses the Fluconazole Resistance Phenotype Mediated by Transmembrane Transporters in <i>Candida albicans</i> and Interferes with Its Biofilm: An In Vitro and In Silico Study

Batzelladine D, a Marine Natural Product, Reverses the Fluconazole Resistance Phenotype Mediated by Transmembrane Transporters in <i>Candida albicans</i> and Interferes with Its Biofilm: An In Vitro and In Silico Study

Numerous <i>Candida</i> species are responsible for fungal infections; however, <i>Candida albicans</i> stands out among the others. Treatment with fluconazole is often ineffective due to the resistance phenotype mediated by transmembrane transporters and/or biofilm formation...

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Bibliographic Details
Main Authors: Levy T. S. Domingos, Daniel C. de Moraes, Mário F. C. Santos, José A. R. Curvelo, Brayan Bayona-Pacheco, Edgar A. Marquez, Anthony W. B. Martinez, Roberto G. S. Berlinck, Antonio Ferreira-Pereira
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Marine Drugs
Subjects:
batzelladine D
marine natural products
marine sponges
fluconazole resistance
multidrug transporters
anti-biofilm
Online Access:https://www.mdpi.com/1660-3397/22/11/502
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