Association of fibrinogen-to-albumin ratio in patients with isolated coronary artery ectasia
Background: Previous research has indicated that chronic inflammation plays a significant role in the development of coronary artery ectasia (CAE). However, there is limited data on the role of plasma fibrinogen-to-albumin ratio (PFAR) in CAE patients. Our study aimed to explore the connection betwe...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jrms.jrms_104_25 |
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| Summary: | Background:
Previous research has indicated that chronic inflammation plays a significant role in the development of coronary artery ectasia (CAE). However, there is limited data on the role of plasma fibrinogen-to-albumin ratio (PFAR) in CAE patients. Our study aimed to explore the connection between PFAR and the presence of CAE.
Materials and Methods:
This research used a case–control methodology. We included a total of 108 consecutive patients who had CAE without any stenosis. Among them, there were 65 males and 43 females, with a mean age of 58.2 ± 8.5 years. The control group included 102 consecutive participants with angiographically normal coronary arteries, consisting of 62 males and 40 women, with a mean age of 57.3 ± 8.6 years. Statistical analyses were conducted using Student’s-t-test, Mann–Whitney U-test, Chi-square test, linear regression, logistic regression, and receiver operating characteristic (ROC) curve analysis.
Results:
PFAR in the CAE group was significantly higher compared to the controls (84.8 ± 7.4 vs. 70.1 ± 9.5, P < 0.001). Using multiple logistic regression showed a strong link between PFAR and CAE, with an odds ratio for PFAR of 1.818 (95% confidence interval [CI] 1.092–6.201; P = 0.005). PFAR was exceeded 72.6, the sensitivity and specificity were 80.2% and 72.6%, respectively. The area under the ROC curve (area under the curve) was 0.731 (95% CI: 0.659–0.803, P = 0.028).
Conclusion:
In our study, we found that PFAR levels were notably higher in the CAE group compared to the control group, and we observed a significant correlation between PFAR and CAE. |
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| ISSN: | 1735-1995 1735-7136 |