Pregnancy and Birth Outcomes among Women with Idiopathic Thrombocytopenic Purpura
Objective. To examine pregnancy and birth outcomes among women with idiopathic thrombocytopenic purpura (ITP) or chronic ITP (cITP) diagnosed before or during pregnancy. Methods. A linkage of mothers and babies within a large US health insurance database that combines enrollment data, pharmacy claim...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2016/8297407 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849396093011361792 |
|---|---|
| author | Diego F. Wyszynski Wendy J. Carman Alan B. Cantor John M. Graham Liza H. Kunz Anne M. Slavotinek Russell S. Kirby John Seeger |
| author_facet | Diego F. Wyszynski Wendy J. Carman Alan B. Cantor John M. Graham Liza H. Kunz Anne M. Slavotinek Russell S. Kirby John Seeger |
| author_sort | Diego F. Wyszynski |
| collection | DOAJ |
| description | Objective. To examine pregnancy and birth outcomes among women with idiopathic thrombocytopenic purpura (ITP) or chronic ITP (cITP) diagnosed before or during pregnancy. Methods. A linkage of mothers and babies within a large US health insurance database that combines enrollment data, pharmacy claims, and medical claims was carried out to identify pregnancies in women with ITP or cITP. Outcomes included preterm birth, elective and spontaneous loss, and major congenital anomalies. Results. Results suggest that women diagnosed with ITP or cITP prior to their estimated date of conception may be at higher risk for stillbirth, fetal loss, and premature delivery. Among 446 pregnancies in women with ITP, 346 resulted in live births. Women with cITP experienced more adverse outcomes than those with a pregnancy-related diagnosis of ITP. Although 7.8% of all live births had major congenital anomalies, the majority were isolated heart defects. Among deliveries in women with cITP, 15.2% of live births were preterm. Conclusions. The results of this study provide further evidence that cause and duration of maternal ITP are important determinants of the outcomes of pregnancy. |
| format | Article |
| id | doaj-art-b23b6696a8c24f56838d0a4ba16b86c1 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-b23b6696a8c24f56838d0a4ba16b86c12025-08-20T03:39:26ZengWileyJournal of Pregnancy2090-27272090-27352016-01-01201610.1155/2016/82974078297407Pregnancy and Birth Outcomes among Women with Idiopathic Thrombocytopenic PurpuraDiego F. Wyszynski0Wendy J. Carman1Alan B. Cantor2John M. Graham3Liza H. Kunz4Anne M. Slavotinek5Russell S. Kirby6John Seeger7Pregistry, Los Angeles, CA 90045, USAEpidemiology, OptumInsight, Waltham, MA 02451, USAChildren’s Hospital Boston, Boston, MA 02115, USAMedical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USAPalo Alto Medical Foundation, Mountain View, CA 94040, USADepartment of Pediatrics, Division of Genetics, University of California, San Francisco, San Francisco, CA 94115, USACollege of Public Health, University of South Florida, Tampa, FL 33612, USAEpidemiology, OptumInsight, Waltham, MA 02451, USAObjective. To examine pregnancy and birth outcomes among women with idiopathic thrombocytopenic purpura (ITP) or chronic ITP (cITP) diagnosed before or during pregnancy. Methods. A linkage of mothers and babies within a large US health insurance database that combines enrollment data, pharmacy claims, and medical claims was carried out to identify pregnancies in women with ITP or cITP. Outcomes included preterm birth, elective and spontaneous loss, and major congenital anomalies. Results. Results suggest that women diagnosed with ITP or cITP prior to their estimated date of conception may be at higher risk for stillbirth, fetal loss, and premature delivery. Among 446 pregnancies in women with ITP, 346 resulted in live births. Women with cITP experienced more adverse outcomes than those with a pregnancy-related diagnosis of ITP. Although 7.8% of all live births had major congenital anomalies, the majority were isolated heart defects. Among deliveries in women with cITP, 15.2% of live births were preterm. Conclusions. The results of this study provide further evidence that cause and duration of maternal ITP are important determinants of the outcomes of pregnancy.http://dx.doi.org/10.1155/2016/8297407 |
| spellingShingle | Diego F. Wyszynski Wendy J. Carman Alan B. Cantor John M. Graham Liza H. Kunz Anne M. Slavotinek Russell S. Kirby John Seeger Pregnancy and Birth Outcomes among Women with Idiopathic Thrombocytopenic Purpura Journal of Pregnancy |
| title | Pregnancy and Birth Outcomes among Women with Idiopathic Thrombocytopenic Purpura |
| title_full | Pregnancy and Birth Outcomes among Women with Idiopathic Thrombocytopenic Purpura |
| title_fullStr | Pregnancy and Birth Outcomes among Women with Idiopathic Thrombocytopenic Purpura |
| title_full_unstemmed | Pregnancy and Birth Outcomes among Women with Idiopathic Thrombocytopenic Purpura |
| title_short | Pregnancy and Birth Outcomes among Women with Idiopathic Thrombocytopenic Purpura |
| title_sort | pregnancy and birth outcomes among women with idiopathic thrombocytopenic purpura |
| url | http://dx.doi.org/10.1155/2016/8297407 |
| work_keys_str_mv | AT diegofwyszynski pregnancyandbirthoutcomesamongwomenwithidiopathicthrombocytopenicpurpura AT wendyjcarman pregnancyandbirthoutcomesamongwomenwithidiopathicthrombocytopenicpurpura AT alanbcantor pregnancyandbirthoutcomesamongwomenwithidiopathicthrombocytopenicpurpura AT johnmgraham pregnancyandbirthoutcomesamongwomenwithidiopathicthrombocytopenicpurpura AT lizahkunz pregnancyandbirthoutcomesamongwomenwithidiopathicthrombocytopenicpurpura AT annemslavotinek pregnancyandbirthoutcomesamongwomenwithidiopathicthrombocytopenicpurpura AT russellskirby pregnancyandbirthoutcomesamongwomenwithidiopathicthrombocytopenicpurpura AT johnseeger pregnancyandbirthoutcomesamongwomenwithidiopathicthrombocytopenicpurpura |