Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical Research
Birds, especially the chick and hen, have been important biomedical research models for centuries due to the accessibility of the avian embryo and the early discovery of avian viruses. Comprehension of avian tumor virology was a milestone in basic cancer research, as was that of non-viral genesis, a...
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MDPI AG
2024-10-01
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| author | Julia Niebora Krzysztof Data Dominika Domagała Małgorzata Józkowiak Saoirse Barrett Tannaz Norizadeh Abbariki Artur Bryja Magdalena Kulus Sławomir Woźniak Hanna Ziemak Hanna Piotrowska-Kempisty Paweł Antosik Dorota Bukowska Paul Mozdziak Piotr Dzięgiel Bartosz Kempisty |
| author_facet | Julia Niebora Krzysztof Data Dominika Domagała Małgorzata Józkowiak Saoirse Barrett Tannaz Norizadeh Abbariki Artur Bryja Magdalena Kulus Sławomir Woźniak Hanna Ziemak Hanna Piotrowska-Kempisty Paweł Antosik Dorota Bukowska Paul Mozdziak Piotr Dzięgiel Bartosz Kempisty |
| author_sort | Julia Niebora |
| collection | DOAJ |
| description | Birds, especially the chick and hen, have been important biomedical research models for centuries due to the accessibility of the avian embryo and the early discovery of avian viruses. Comprehension of avian tumor virology was a milestone in basic cancer research, as was that of non-viral genesis, as it enabled the discovery of oncogenes. Furthermore, studies on avian viruses provided initial insights into Kaposi’s sarcoma and EBV-induced diseases. However, the role of birds in human carcinogenesis extends beyond the realm of virology research. Utilization of CAM, the chorioallantoic membrane, an easily accessible extraembryonic tissue with rich vasculature, has enabled studies on tumor-induced angiogenesis and metastasis and the efficient screening of potential anti-cancer compounds. Also, the chick embryo alone is an effective preclinical in vivo patient-derived xenograft model, which is important for the development of personalized therapies. Furthermore, adult birds may also closely resemble human oncogenesis, as evidenced by the laying hen, which is the only animal model of a spontaneous form of ovarian cancer. Avian models may create an interesting alternative compared with mammalian models, enabling the creation of a relatively cost-effective and easy-to-maintain platform to address key questions in cancer biology. |
| format | Article |
| id | doaj-art-b22d23fdd97a45f29e399709626ce14e |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-b22d23fdd97a45f29e399709626ce14e2024-11-08T14:34:32ZengMDPI AGCells2073-44092024-10-011321179710.3390/cells13211797Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical ResearchJulia Niebora0Krzysztof Data1Dominika Domagała2Małgorzata Józkowiak3Saoirse Barrett4Tannaz Norizadeh Abbariki5Artur Bryja6Magdalena Kulus7Sławomir Woźniak8Hanna Ziemak9Hanna Piotrowska-Kempisty10Paweł Antosik11Dorota Bukowska12Paul Mozdziak13Piotr Dzięgiel14Bartosz Kempisty15Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, PolandDivision of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, PolandDivision of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, PolandDivision of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, PolandHuman Clinical Embryology & Assisted Conception, School of Medicine, University of Dundee, Dundee DD1 4HN, UKFlyblast BV, 2020 Antwerp, BelgiumDivision of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, PolandDepartment of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, PolandDivision of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, PolandVeterinary Clinic of the Nicolaus Copernicus University in Torun, 87-100 Torun, PolandDepartment of Toxicology, Poznan University of Medical Sciences, 60-631 Poznan, PolandDepartment of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, PolandDepartment of Diagnostics and Clinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, PolandPrestage Department of Poultry Science, North Carolina State University, Raleigh, NC 27695, USADivision of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, PolandDivision of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, PolandBirds, especially the chick and hen, have been important biomedical research models for centuries due to the accessibility of the avian embryo and the early discovery of avian viruses. Comprehension of avian tumor virology was a milestone in basic cancer research, as was that of non-viral genesis, as it enabled the discovery of oncogenes. Furthermore, studies on avian viruses provided initial insights into Kaposi’s sarcoma and EBV-induced diseases. However, the role of birds in human carcinogenesis extends beyond the realm of virology research. Utilization of CAM, the chorioallantoic membrane, an easily accessible extraembryonic tissue with rich vasculature, has enabled studies on tumor-induced angiogenesis and metastasis and the efficient screening of potential anti-cancer compounds. Also, the chick embryo alone is an effective preclinical in vivo patient-derived xenograft model, which is important for the development of personalized therapies. Furthermore, adult birds may also closely resemble human oncogenesis, as evidenced by the laying hen, which is the only animal model of a spontaneous form of ovarian cancer. Avian models may create an interesting alternative compared with mammalian models, enabling the creation of a relatively cost-effective and easy-to-maintain platform to address key questions in cancer biology.https://www.mdpi.com/2073-4409/13/21/1797oncoviruseshen modelovarian cancercarcinogenesischorioallantoic membrane |
| spellingShingle | Julia Niebora Krzysztof Data Dominika Domagała Małgorzata Józkowiak Saoirse Barrett Tannaz Norizadeh Abbariki Artur Bryja Magdalena Kulus Sławomir Woźniak Hanna Ziemak Hanna Piotrowska-Kempisty Paweł Antosik Dorota Bukowska Paul Mozdziak Piotr Dzięgiel Bartosz Kempisty Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical Research Cells oncoviruses hen model ovarian cancer carcinogenesis chorioallantoic membrane |
| title | Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical Research |
| title_full | Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical Research |
| title_fullStr | Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical Research |
| title_full_unstemmed | Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical Research |
| title_short | Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical Research |
| title_sort | avian models for human carcinogenesis recent findings from molecular and clinical research |
| topic | oncoviruses hen model ovarian cancer carcinogenesis chorioallantoic membrane |
| url | https://www.mdpi.com/2073-4409/13/21/1797 |
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