RETRACTED: Fibronectin enhances tumor metastasis through B7‐H3 in clear cell renal cell carcinoma
B7 homolog 3 (B7‐H3) plays an important role in tumor biology, but the molecular mechanism underlying the role of B7‐H3 in tumor metastasis remains unclear. In this article, our analysis of The Cancer Genome Atlas database suggested that B7‐H3 expression is associated with poor prognosis of patients...
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| Format: | Article |
| Language: | English |
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Wiley
2021-11-01
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| Series: | FEBS Open Bio |
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| Online Access: | https://doi.org/10.1002/2211-5463.13280 |
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| author | Jinjing Xie Meiyun Sun Dongze Zhang Chunyang Chen Simin Lin Guangbo Zhang |
| author_facet | Jinjing Xie Meiyun Sun Dongze Zhang Chunyang Chen Simin Lin Guangbo Zhang |
| author_sort | Jinjing Xie |
| collection | DOAJ |
| description | B7 homolog 3 (B7‐H3) plays an important role in tumor biology, but the molecular mechanism underlying the role of B7‐H3 in tumor metastasis remains unclear. In this article, our analysis of The Cancer Genome Atlas database suggested that B7‐H3 expression is associated with poor prognosis of patients with clear cell renal cell carcinoma (ccRCC). B7‐H3 knockdown affected the expression of metastasis‐related genes and significantly suppressed the metastasis of ccRCC cells, but it had no significant effect on the proliferation of ccRCC cells. Database analysis revealed a strong positive correlation between B7‐H3 and fibronectin (FN) in ccRCC cells, and further study also confirmed that FN interacts with B7‐H3. Silencing FN expression inhibited the migration and invasion of ccRCC cells, whereas exogenous FN promoted the migration and invasion of ccRCC cells, which was accompanied by activation of kinases [namely, phosphorylated (p)‐phosphoinositide 3‐kinase, p‐protein kinase B, p‐p38 and p‐extracellular regulated protein kinase]. B7‐H3 knockdown abolished the prometastatic effect of FN. In conclusion, our data suggest that B7‐H3 binds to exogenous FN and promotes the metastasis of ccRCC cells. |
| format | Article |
| id | doaj-art-b22bb7a2a11a46a7a37e3a99a4e2d60e |
| institution | Kabale University |
| issn | 2211-5463 |
| language | English |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj-art-b22bb7a2a11a46a7a37e3a99a4e2d60e2025-08-20T03:49:22ZengWileyFEBS Open Bio2211-54632021-11-0111112977298710.1002/2211-5463.13280RETRACTED: Fibronectin enhances tumor metastasis through B7‐H3 in clear cell renal cell carcinomaJinjing Xie0Meiyun Sun1Dongze Zhang2Chunyang Chen3Simin Lin4Guangbo Zhang5Medical College of Soochow University Suzhou ChinaMedical College of Soochow University Suzhou ChinaJiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow University Suzhou ChinaJiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow University Suzhou ChinaJiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow University Suzhou ChinaMedical College of Soochow University Suzhou ChinaB7 homolog 3 (B7‐H3) plays an important role in tumor biology, but the molecular mechanism underlying the role of B7‐H3 in tumor metastasis remains unclear. In this article, our analysis of The Cancer Genome Atlas database suggested that B7‐H3 expression is associated with poor prognosis of patients with clear cell renal cell carcinoma (ccRCC). B7‐H3 knockdown affected the expression of metastasis‐related genes and significantly suppressed the metastasis of ccRCC cells, but it had no significant effect on the proliferation of ccRCC cells. Database analysis revealed a strong positive correlation between B7‐H3 and fibronectin (FN) in ccRCC cells, and further study also confirmed that FN interacts with B7‐H3. Silencing FN expression inhibited the migration and invasion of ccRCC cells, whereas exogenous FN promoted the migration and invasion of ccRCC cells, which was accompanied by activation of kinases [namely, phosphorylated (p)‐phosphoinositide 3‐kinase, p‐protein kinase B, p‐p38 and p‐extracellular regulated protein kinase]. B7‐H3 knockdown abolished the prometastatic effect of FN. In conclusion, our data suggest that B7‐H3 binds to exogenous FN and promotes the metastasis of ccRCC cells.https://doi.org/10.1002/2211-5463.13280B7‐H3fibronectinclear cell renal cell carcinomatumor metastasis |
| spellingShingle | Jinjing Xie Meiyun Sun Dongze Zhang Chunyang Chen Simin Lin Guangbo Zhang RETRACTED: Fibronectin enhances tumor metastasis through B7‐H3 in clear cell renal cell carcinoma FEBS Open Bio B7‐H3 fibronectin clear cell renal cell carcinoma tumor metastasis |
| title | RETRACTED: Fibronectin enhances tumor metastasis through B7‐H3 in clear cell renal cell carcinoma |
| title_full | RETRACTED: Fibronectin enhances tumor metastasis through B7‐H3 in clear cell renal cell carcinoma |
| title_fullStr | RETRACTED: Fibronectin enhances tumor metastasis through B7‐H3 in clear cell renal cell carcinoma |
| title_full_unstemmed | RETRACTED: Fibronectin enhances tumor metastasis through B7‐H3 in clear cell renal cell carcinoma |
| title_short | RETRACTED: Fibronectin enhances tumor metastasis through B7‐H3 in clear cell renal cell carcinoma |
| title_sort | retracted fibronectin enhances tumor metastasis through b7 h3 in clear cell renal cell carcinoma |
| topic | B7‐H3 fibronectin clear cell renal cell carcinoma tumor metastasis |
| url | https://doi.org/10.1002/2211-5463.13280 |
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