Arginine as host directed therapy in tuberculosis: insights from modulating arginine metabolism by supplementation and arginase inhibition

Arginine as host directed therapy in tuberculosis: insights from modulating arginine metabolism by supplementation and arginase inhibition

Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global health challenge. Arginine metabolism is central to immune responses, regulating nitric oxide (NO) production via inducible NO synthase (Nos2) and competing pathways mediated by arginases (Arg1 and Arg2). This s...

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Bibliographic Details
Main Authors: Qingkui Jiang, Ranjeet Kumar, Yi Zhao, Selvakumar Subbian, Lanbo Shi
Format: Article
Language:English
Published: BioMed Central 2025-03-01
Series:One Health Advances
Subjects:
Arginase
Arginine metabolsim
Mitophagy
Cytokine network
Mycobacterium tuberculosis
Host directed therapy
Online Access:https://doi.org/10.1186/s44280-025-00070-6
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