The thromboelastogram is confounded by hematocrit in clinical samples tested on both mechanical and acoustic platforms
Red blood cells are critical participants in normal hemostasis, but in vitro experiments have shown that the thromboelastogram (TEG) maximum amplitude has a paradoxical inverse relationship with hematocrit. This study reviewed all samples at a single academic institution where any mechanical (TEG 50...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1421727/full |
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| author | Aaron S. Hess Aaron S. Hess |
| author_facet | Aaron S. Hess Aaron S. Hess |
| author_sort | Aaron S. Hess |
| collection | DOAJ |
| description | Red blood cells are critical participants in normal hemostasis, but in vitro experiments have shown that the thromboelastogram (TEG) maximum amplitude has a paradoxical inverse relationship with hematocrit. This study reviewed all samples at a single academic institution where any mechanical (TEG 5000) or acoustic (TEG 6s) TEG was drawn within 5 min of hematocrit measurement. A total of 7,176 samples were identified using complete TEG and conventional coagulation test data (6,384 mechanical, 744 acoustic, and 48 both). In the primary analysis, hematocrit was negatively associated with the maximum amplitude on both mechanical and acoustic platforms after adjusting for relevant confounders. This suggests that the thromboelastogram may misrepresent the contribution of red blood cells in normal hemostasis. |
| format | Article |
| id | doaj-art-b1f55ece2f794c38b88d701c00df8035 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-b1f55ece2f794c38b88d701c00df80352024-11-13T05:00:51ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-11-011110.3389/fmed.2024.14217271421727The thromboelastogram is confounded by hematocrit in clinical samples tested on both mechanical and acoustic platformsAaron S. Hess0Aaron S. Hess1Department of Anesthesiology, University of Wisconsin, Madison, WI, United StatesDepartment of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, United StatesRed blood cells are critical participants in normal hemostasis, but in vitro experiments have shown that the thromboelastogram (TEG) maximum amplitude has a paradoxical inverse relationship with hematocrit. This study reviewed all samples at a single academic institution where any mechanical (TEG 5000) or acoustic (TEG 6s) TEG was drawn within 5 min of hematocrit measurement. A total of 7,176 samples were identified using complete TEG and conventional coagulation test data (6,384 mechanical, 744 acoustic, and 48 both). In the primary analysis, hematocrit was negatively associated with the maximum amplitude on both mechanical and acoustic platforms after adjusting for relevant confounders. This suggests that the thromboelastogram may misrepresent the contribution of red blood cells in normal hemostasis.https://www.frontiersin.org/articles/10.3389/fmed.2024.1421727/fullhemostasisthromboelastogramred blood cellsfibrinogenhematocrit |
| spellingShingle | Aaron S. Hess Aaron S. Hess The thromboelastogram is confounded by hematocrit in clinical samples tested on both mechanical and acoustic platforms Frontiers in Medicine hemostasis thromboelastogram red blood cells fibrinogen hematocrit |
| title | The thromboelastogram is confounded by hematocrit in clinical samples tested on both mechanical and acoustic platforms |
| title_full | The thromboelastogram is confounded by hematocrit in clinical samples tested on both mechanical and acoustic platforms |
| title_fullStr | The thromboelastogram is confounded by hematocrit in clinical samples tested on both mechanical and acoustic platforms |
| title_full_unstemmed | The thromboelastogram is confounded by hematocrit in clinical samples tested on both mechanical and acoustic platforms |
| title_short | The thromboelastogram is confounded by hematocrit in clinical samples tested on both mechanical and acoustic platforms |
| title_sort | thromboelastogram is confounded by hematocrit in clinical samples tested on both mechanical and acoustic platforms |
| topic | hemostasis thromboelastogram red blood cells fibrinogen hematocrit |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1421727/full |
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