Impact of thyrotropin levels on outcomes in T1N0M0 papillary thyroid cancer after microwave ablation
Objective To evaluate the impact of thyroid-stimulating hormone (TSH) levels on tumor progression and survival in patients with uni- and multifocal T1N0M0 papillary thyroid cancer (PTC) treated with microwave ablation (MWA).Methods This retrospective study analyzed the records of 525 patients with u...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2437111 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841560915898531840 |
|---|---|
| author | Ying Wei Zhen-Long Zhao Jie Wu Shi-Liang Cao Na Yu Li-Li Peng Yan Li Ming-An Yu |
| author_facet | Ying Wei Zhen-Long Zhao Jie Wu Shi-Liang Cao Na Yu Li-Li Peng Yan Li Ming-An Yu |
| author_sort | Ying Wei |
| collection | DOAJ |
| description | Objective To evaluate the impact of thyroid-stimulating hormone (TSH) levels on tumor progression and survival in patients with uni- and multifocal T1N0M0 papillary thyroid cancer (PTC) treated with microwave ablation (MWA).Methods This retrospective study analyzed the records of 525 patients with uni- and multifocal T1N0M0 PTC who underwent MWA from January 2015 to December 2022. Patients were stratified into uni-focal (U-PTC) and multifocal (M-PTC) groups and further categorized based on post-ablation TSH levels into low (≤1 mU/L), medium (1–2 mU/L), and high (>2 mU/L) subgroups. The tumor progression rates and progression-free survival were assessed.Results In U-PTC patients, lower TSH levels were significantly associated with higher tumor progression rates (10.1%) compared to those in the medium (2.9%) and high (2.1%) TSH groups (p = .009). Conversely, in M-PTC patients, tumor progression rates did not vary significantly across TSH levels. Progression-free survival rates in U-PTC patients were notably lower at the 5-year mark in the low TSH group (85.7%) compared to the medium TSH group (96.5%, p = .046). However, progression-free survival rates in M-PTC patients showed convergence across all TSH levels by the 5-year follow-up.Conclusion Maintaining TSH levels within the normal range post-ablation may be appropriate for managing T1N0M0 PTC treated with MWA, but randomized controlled trials are needed to confirm optimal TSH targets and their impact on outcomes. |
| format | Article |
| id | doaj-art-b1d68a02b0384d96aee934b217be70fc |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-b1d68a02b0384d96aee934b217be70fc2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2437111Impact of thyrotropin levels on outcomes in T1N0M0 papillary thyroid cancer after microwave ablationYing Wei0Zhen-Long Zhao1Jie Wu2Shi-Liang Cao3Na Yu4Li-Li Peng5Yan Li6Ming-An Yu7Department of Interventional Medicine, China–Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China–Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China–Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China–Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China–Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China–Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China–Japan Friendship Hospital, Beijing, ChinaDepartment of Interventional Medicine, China–Japan Friendship Hospital, Beijing, ChinaObjective To evaluate the impact of thyroid-stimulating hormone (TSH) levels on tumor progression and survival in patients with uni- and multifocal T1N0M0 papillary thyroid cancer (PTC) treated with microwave ablation (MWA).Methods This retrospective study analyzed the records of 525 patients with uni- and multifocal T1N0M0 PTC who underwent MWA from January 2015 to December 2022. Patients were stratified into uni-focal (U-PTC) and multifocal (M-PTC) groups and further categorized based on post-ablation TSH levels into low (≤1 mU/L), medium (1–2 mU/L), and high (>2 mU/L) subgroups. The tumor progression rates and progression-free survival were assessed.Results In U-PTC patients, lower TSH levels were significantly associated with higher tumor progression rates (10.1%) compared to those in the medium (2.9%) and high (2.1%) TSH groups (p = .009). Conversely, in M-PTC patients, tumor progression rates did not vary significantly across TSH levels. Progression-free survival rates in U-PTC patients were notably lower at the 5-year mark in the low TSH group (85.7%) compared to the medium TSH group (96.5%, p = .046). However, progression-free survival rates in M-PTC patients showed convergence across all TSH levels by the 5-year follow-up.Conclusion Maintaining TSH levels within the normal range post-ablation may be appropriate for managing T1N0M0 PTC treated with MWA, but randomized controlled trials are needed to confirm optimal TSH targets and their impact on outcomes.https://www.tandfonline.com/doi/10.1080/02656736.2024.2437111Microwave ablationpapillary thyroid cancerthyroid stimulating hormonetumor progressiondisease-free survival |
| spellingShingle | Ying Wei Zhen-Long Zhao Jie Wu Shi-Liang Cao Na Yu Li-Li Peng Yan Li Ming-An Yu Impact of thyrotropin levels on outcomes in T1N0M0 papillary thyroid cancer after microwave ablation International Journal of Hyperthermia Microwave ablation papillary thyroid cancer thyroid stimulating hormone tumor progression disease-free survival |
| title | Impact of thyrotropin levels on outcomes in T1N0M0 papillary thyroid cancer after microwave ablation |
| title_full | Impact of thyrotropin levels on outcomes in T1N0M0 papillary thyroid cancer after microwave ablation |
| title_fullStr | Impact of thyrotropin levels on outcomes in T1N0M0 papillary thyroid cancer after microwave ablation |
| title_full_unstemmed | Impact of thyrotropin levels on outcomes in T1N0M0 papillary thyroid cancer after microwave ablation |
| title_short | Impact of thyrotropin levels on outcomes in T1N0M0 papillary thyroid cancer after microwave ablation |
| title_sort | impact of thyrotropin levels on outcomes in t1n0m0 papillary thyroid cancer after microwave ablation |
| topic | Microwave ablation papillary thyroid cancer thyroid stimulating hormone tumor progression disease-free survival |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2437111 |
| work_keys_str_mv | AT yingwei impactofthyrotropinlevelsonoutcomesint1n0m0papillarythyroidcanceraftermicrowaveablation AT zhenlongzhao impactofthyrotropinlevelsonoutcomesint1n0m0papillarythyroidcanceraftermicrowaveablation AT jiewu impactofthyrotropinlevelsonoutcomesint1n0m0papillarythyroidcanceraftermicrowaveablation AT shiliangcao impactofthyrotropinlevelsonoutcomesint1n0m0papillarythyroidcanceraftermicrowaveablation AT nayu impactofthyrotropinlevelsonoutcomesint1n0m0papillarythyroidcanceraftermicrowaveablation AT lilipeng impactofthyrotropinlevelsonoutcomesint1n0m0papillarythyroidcanceraftermicrowaveablation AT yanli impactofthyrotropinlevelsonoutcomesint1n0m0papillarythyroidcanceraftermicrowaveablation AT minganyu impactofthyrotropinlevelsonoutcomesint1n0m0papillarythyroidcanceraftermicrowaveablation |