Effects of acetazolamide on intracranial pressure and brain tissue oxygenation on patients with acute brain injury: A pilot physiological study
Abstract The effect of acetazolamide on regional brain tissue oxygenation in patients with acute brain injury (ABI) is unknown. We studied adult patients with ABI who received acetazolamide as per the treating physician's decision and had ICP and brain oxygen pressure (PbtO2) monitoring. Baseli...
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Wiley
2025-01-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70159 |
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| author | Anas Hachlouf Claudia Stella Irene Cavalli Elisa Gouvêa Bogossian Sophie Schuind Marco Anderloni Fabio Silvio Taccone |
| author_facet | Anas Hachlouf Claudia Stella Irene Cavalli Elisa Gouvêa Bogossian Sophie Schuind Marco Anderloni Fabio Silvio Taccone |
| author_sort | Anas Hachlouf |
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| description | Abstract The effect of acetazolamide on regional brain tissue oxygenation in patients with acute brain injury (ABI) is unknown. We studied adult patients with ABI who received acetazolamide as per the treating physician's decision and had ICP and brain oxygen pressure (PbtO2) monitoring. Baseline measurements of ICP, cerebral perfusion pressure (CPP), and PbtO2 were taken before administering acetazolamide; subsequent measurements were recorded every 5 min for a total of 20 min. Mean cerebral blood velocities (FVm) and pulsatility index (PI) were measured using transcranial color‐coded duplex (TCCD) sonography at baseline and after 20 min. Fourteen patients with subarachnoid hemorrhage (n = 6), traumatic brain injury (n = 7), and intracranial hemorrhage (n = 1) were included. Following administration of acetazolamide, ICP showed a significant increase within 20 min (p < 0.001), with no significant change in CPP (p = 0.08). PbtO2 demonstrated a significant increase (p < 0.001), with a noticeable change observed at 10 min after acetazolamide administration (15 [14–17] vs. 28 [26–30] mmHg). Additionally, FVm exhibited a significant increase (p < 0.001), and PI showed a reduction (p < 0.001). Administration of acetazolamide in ABI patients resulted in a significant increase in brain oxygenation, associated with a rise in ICP and FVm, suggesting increased cerebral volume and vasodilation. |
| format | Article |
| id | doaj-art-b1d074aeae054871829135495592653b |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-01-01 |
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| series | Physiological Reports |
| spelling | doaj-art-b1d074aeae054871829135495592653b2025-01-15T13:36:31ZengWileyPhysiological Reports2051-817X2025-01-01131n/an/a10.14814/phy2.70159Effects of acetazolamide on intracranial pressure and brain tissue oxygenation on patients with acute brain injury: A pilot physiological studyAnas Hachlouf0Claudia Stella1Irene Cavalli2Elisa Gouvêa Bogossian3Sophie Schuind4Marco Anderloni5Fabio Silvio Taccone6Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB) Université Libre de Bruxelles (ULB) Bruxelles BelgiumDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB) Université Libre de Bruxelles (ULB) Bruxelles BelgiumDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB) Université Libre de Bruxelles (ULB) Bruxelles BelgiumDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB) Université Libre de Bruxelles (ULB) Bruxelles BelgiumDepartment of Neurosurgery, Hôpital Universitaire de Bruxelles (HUB) Université Libre de Bruxelles (ULB) Bruxelles BelgiumDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB) Université Libre de Bruxelles (ULB) Bruxelles BelgiumDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB) Université Libre de Bruxelles (ULB) Bruxelles BelgiumAbstract The effect of acetazolamide on regional brain tissue oxygenation in patients with acute brain injury (ABI) is unknown. We studied adult patients with ABI who received acetazolamide as per the treating physician's decision and had ICP and brain oxygen pressure (PbtO2) monitoring. Baseline measurements of ICP, cerebral perfusion pressure (CPP), and PbtO2 were taken before administering acetazolamide; subsequent measurements were recorded every 5 min for a total of 20 min. Mean cerebral blood velocities (FVm) and pulsatility index (PI) were measured using transcranial color‐coded duplex (TCCD) sonography at baseline and after 20 min. Fourteen patients with subarachnoid hemorrhage (n = 6), traumatic brain injury (n = 7), and intracranial hemorrhage (n = 1) were included. Following administration of acetazolamide, ICP showed a significant increase within 20 min (p < 0.001), with no significant change in CPP (p = 0.08). PbtO2 demonstrated a significant increase (p < 0.001), with a noticeable change observed at 10 min after acetazolamide administration (15 [14–17] vs. 28 [26–30] mmHg). Additionally, FVm exhibited a significant increase (p < 0.001), and PI showed a reduction (p < 0.001). Administration of acetazolamide in ABI patients resulted in a significant increase in brain oxygenation, associated with a rise in ICP and FVm, suggesting increased cerebral volume and vasodilation.https://doi.org/10.14814/phy2.70159acetazolamideacute brain injurycerebral blood flowcerebral oxygenationintracranial pressure |
| spellingShingle | Anas Hachlouf Claudia Stella Irene Cavalli Elisa Gouvêa Bogossian Sophie Schuind Marco Anderloni Fabio Silvio Taccone Effects of acetazolamide on intracranial pressure and brain tissue oxygenation on patients with acute brain injury: A pilot physiological study Physiological Reports acetazolamide acute brain injury cerebral blood flow cerebral oxygenation intracranial pressure |
| title | Effects of acetazolamide on intracranial pressure and brain tissue oxygenation on patients with acute brain injury: A pilot physiological study |
| title_full | Effects of acetazolamide on intracranial pressure and brain tissue oxygenation on patients with acute brain injury: A pilot physiological study |
| title_fullStr | Effects of acetazolamide on intracranial pressure and brain tissue oxygenation on patients with acute brain injury: A pilot physiological study |
| title_full_unstemmed | Effects of acetazolamide on intracranial pressure and brain tissue oxygenation on patients with acute brain injury: A pilot physiological study |
| title_short | Effects of acetazolamide on intracranial pressure and brain tissue oxygenation on patients with acute brain injury: A pilot physiological study |
| title_sort | effects of acetazolamide on intracranial pressure and brain tissue oxygenation on patients with acute brain injury a pilot physiological study |
| topic | acetazolamide acute brain injury cerebral blood flow cerebral oxygenation intracranial pressure |
| url | https://doi.org/10.14814/phy2.70159 |
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