Ayurvedic perspective of dietary risk factors of colorectal cancers - A hospital-based case control study
Background: The rising prevalence of colorectal cancer (CRC) may be attributed to various nutritional and behavioural factors, making both factors as important topics for discussion to the layman and the oncology community. Objective: To explore additional dietary risk factors, other than those alre...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Journal of Ayurveda and Integrative Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0975947624000846 |
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| author | Sadanand Sardeshmukh Vineeta Deshmukh Vasanti Godse Shweta Gujar Sneha Dalvi Swapna Kulkarni Sushama Bhuvad Nilambari Sardeshmukh Bhagyashree Sardeshmukh Dhananjay Deshpande Vinita Awalkanthe Amruta Salunkhe Anita Redekar Suchita Vaidya Sandeep Chavan |
| author_facet | Sadanand Sardeshmukh Vineeta Deshmukh Vasanti Godse Shweta Gujar Sneha Dalvi Swapna Kulkarni Sushama Bhuvad Nilambari Sardeshmukh Bhagyashree Sardeshmukh Dhananjay Deshpande Vinita Awalkanthe Amruta Salunkhe Anita Redekar Suchita Vaidya Sandeep Chavan |
| author_sort | Sadanand Sardeshmukh |
| collection | DOAJ |
| description | Background: The rising prevalence of colorectal cancer (CRC) may be attributed to various nutritional and behavioural factors, making both factors as important topics for discussion to the layman and the oncology community. Objective: To explore additional dietary risk factors, other than those already known, according to the Ayurvedic perspective in CRC patients. Methods: Detail dietary data was collected from 420 patients of CRC and 116 healthy volunteers registered at our institute with the help of a food frequency questionnaire. Descriptive analysis was done by plotting radar charts, whereas the logistic regression models were used to calculate the adjusted Odd Ratios (ORs) associated with consumption of green chilli, red chilli powder and curd, individually and in combinations. Results: The controls in the present study were younger, had more males, the majority of them belonged to middle- and lower-income groups and had a family history of cancer as compared with cohort of case studies. Green chilli consumption was found to be the maximum within the lower-income group (n = 18, 66.67%), while that of red chilli (n = 150, 48.23%), and curd (n = 107, 34.04%) within the middle class. Maximum consumption of green chillies (Males n = 48, 29.27%; Females n = 36, 21.95%), red chillies (Males n = 40, 29.85%; Females n = 16, 24.61%) and curd (Males n = 31, 28.97%) was observed in the age group 46 to 60 irrespective of sex. Tobacco was found to be the most common addiction in all groups. The maximum number of patients frequently consuming these three dietary items presented majorly with rectal cancer, and liver metastasis and were in advanced grade and stage of cancer. Curd and curd with red chilli powder had a significant association with the development of CRC with an OR of 2.7280 (95% CI 1.6346 to 4.5531) and 5.0806 (95% CI 2.4015 to 10.7485), respectively, which was highly significant (p < 0.0001). Green chilli was notably an associated risk with an OR of 2.0095 (95% CI 1.3258 to 3.0458), which was also statistically significant (p = 0.001). Red chilli powder and green chilli with curd had ORs as 1.6917 (95% CI 1.1105 to 2.5771) and 2.1778 (95% CI 1.1591 to 4.0918) with p = 0.0144 and 0.0156, respectively. Conclusion: In the present study, green chilli, red chilli, and curd are identified as additional dietary risk factors for colorectal cancers, owing to their ability to produce chronic inflammation leading to various inflammatory conditions including cancer. |
| format | Article |
| id | doaj-art-b1ad829808b14bd0b406f5a35b366795 |
| institution | Kabale University |
| issn | 0975-9476 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj-art-b1ad829808b14bd0b406f5a35b3667952024-12-23T04:19:01ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762024-11-01156100969Ayurvedic perspective of dietary risk factors of colorectal cancers - A hospital-based case control studySadanand Sardeshmukh0Vineeta Deshmukh1Vasanti Godse2Shweta Gujar3Sneha Dalvi4Swapna Kulkarni5Sushama Bhuvad6Nilambari Sardeshmukh7Bhagyashree Sardeshmukh8Dhananjay Deshpande9Vinita Awalkanthe10Amruta Salunkhe11Anita Redekar12Suchita Vaidya13Sandeep Chavan14Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaCorresponding author. Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, 412207, Maharashtra, India.; Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, Maharashtra, 412207, IndiaBackground: The rising prevalence of colorectal cancer (CRC) may be attributed to various nutritional and behavioural factors, making both factors as important topics for discussion to the layman and the oncology community. Objective: To explore additional dietary risk factors, other than those already known, according to the Ayurvedic perspective in CRC patients. Methods: Detail dietary data was collected from 420 patients of CRC and 116 healthy volunteers registered at our institute with the help of a food frequency questionnaire. Descriptive analysis was done by plotting radar charts, whereas the logistic regression models were used to calculate the adjusted Odd Ratios (ORs) associated with consumption of green chilli, red chilli powder and curd, individually and in combinations. Results: The controls in the present study were younger, had more males, the majority of them belonged to middle- and lower-income groups and had a family history of cancer as compared with cohort of case studies. Green chilli consumption was found to be the maximum within the lower-income group (n = 18, 66.67%), while that of red chilli (n = 150, 48.23%), and curd (n = 107, 34.04%) within the middle class. Maximum consumption of green chillies (Males n = 48, 29.27%; Females n = 36, 21.95%), red chillies (Males n = 40, 29.85%; Females n = 16, 24.61%) and curd (Males n = 31, 28.97%) was observed in the age group 46 to 60 irrespective of sex. Tobacco was found to be the most common addiction in all groups. The maximum number of patients frequently consuming these three dietary items presented majorly with rectal cancer, and liver metastasis and were in advanced grade and stage of cancer. Curd and curd with red chilli powder had a significant association with the development of CRC with an OR of 2.7280 (95% CI 1.6346 to 4.5531) and 5.0806 (95% CI 2.4015 to 10.7485), respectively, which was highly significant (p < 0.0001). Green chilli was notably an associated risk with an OR of 2.0095 (95% CI 1.3258 to 3.0458), which was also statistically significant (p = 0.001). Red chilli powder and green chilli with curd had ORs as 1.6917 (95% CI 1.1105 to 2.5771) and 2.1778 (95% CI 1.1591 to 4.0918) with p = 0.0144 and 0.0156, respectively. Conclusion: In the present study, green chilli, red chilli, and curd are identified as additional dietary risk factors for colorectal cancers, owing to their ability to produce chronic inflammation leading to various inflammatory conditions including cancer.http://www.sciencedirect.com/science/article/pii/S0975947624000846ArbudaColorectal cancerCancerCurdChilliRisk factors |
| spellingShingle | Sadanand Sardeshmukh Vineeta Deshmukh Vasanti Godse Shweta Gujar Sneha Dalvi Swapna Kulkarni Sushama Bhuvad Nilambari Sardeshmukh Bhagyashree Sardeshmukh Dhananjay Deshpande Vinita Awalkanthe Amruta Salunkhe Anita Redekar Suchita Vaidya Sandeep Chavan Ayurvedic perspective of dietary risk factors of colorectal cancers - A hospital-based case control study Journal of Ayurveda and Integrative Medicine Arbuda Colorectal cancer Cancer Curd Chilli Risk factors |
| title | Ayurvedic perspective of dietary risk factors of colorectal cancers - A hospital-based case control study |
| title_full | Ayurvedic perspective of dietary risk factors of colorectal cancers - A hospital-based case control study |
| title_fullStr | Ayurvedic perspective of dietary risk factors of colorectal cancers - A hospital-based case control study |
| title_full_unstemmed | Ayurvedic perspective of dietary risk factors of colorectal cancers - A hospital-based case control study |
| title_short | Ayurvedic perspective of dietary risk factors of colorectal cancers - A hospital-based case control study |
| title_sort | ayurvedic perspective of dietary risk factors of colorectal cancers a hospital based case control study |
| topic | Arbuda Colorectal cancer Cancer Curd Chilli Risk factors |
| url | http://www.sciencedirect.com/science/article/pii/S0975947624000846 |
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