Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study
Objective The association between ulcerative colitis (UC) and colorectal cancer (CRC) is widely accepted, although attenuated risk has been reported in recent years. Colonoscopic surveillance is recommended with intervals based on established clinical risk factors. Nevertheless, a significant number...
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| Language: | English |
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BMJ Publishing Group
2020-12-01
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| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/7/1/e000361.full |
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| author | Tomm Bernklev Pasquale Klepp Stephan Brackmann Milada Cvancarova Marte Lie Hoivik Øistein Hovde Magne Henriksen Gert Huppertz-Hauss Ole Hoie Iril Kempski-Monstad Inger Camilla Solberg Njaal Stray Jorgen Jahnsen Bjorn Moum |
| author_facet | Tomm Bernklev Pasquale Klepp Stephan Brackmann Milada Cvancarova Marte Lie Hoivik Øistein Hovde Magne Henriksen Gert Huppertz-Hauss Ole Hoie Iril Kempski-Monstad Inger Camilla Solberg Njaal Stray Jorgen Jahnsen Bjorn Moum |
| author_sort | Tomm Bernklev |
| collection | DOAJ |
| description | Objective The association between ulcerative colitis (UC) and colorectal cancer (CRC) is widely accepted, although attenuated risk has been reported in recent years. Colonoscopic surveillance is recommended with intervals based on established clinical risk factors. Nevertheless, a significant number of patients develop interval cancers, indicating the need of improved individualised assessment. In the present study, we evaluated clinical risk factors associated with CRC during a prescheduled follow-up 20 years after diagnosis, the IBSEN study.Design A population-based inception cohort of patients diagnosed with inflammatory bowel disease from 1 January 1990 until 31 December 1993, prospectively followed at 1, 5, 10 and 20 years after diagnosis. A total of 517 patients with UC were included; 264 (51 %) men; median age at inclusion 37.4 years (4–88).Results The overall incidence of CRC was 1.6% (8/517) at a 20-year follow-up. The total lifetime risk of CRC prior to or after UC diagnosis was 2.3%. (12/517). Patients older than 70 years at diagnosis had a 15-fold higher risk of CRC compared with those diagnosed when younger than 40 years, with HR 15.68 (95% CI: 1.31 to 187.92). Neither sex, first-degree relative with CRC, extent of colitis nor primary sclerosing cholangitis affected the risk of CRC.Conclusion The risk of CRC in UC was low and comparable with the risk of CRC in the background population of Norway. |
| format | Article |
| id | doaj-art-b1a50baed0c94cc7b63566680dfc95f3 |
| institution | Kabale University |
| issn | 2054-4774 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj-art-b1a50baed0c94cc7b63566680dfc95f32024-12-14T12:05:09ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742020-12-017110.1136/bmjgast-2019-000361Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN studyTomm Bernklev0Pasquale Klepp1Stephan Brackmann2Milada Cvancarova3Marte Lie Hoivik4Øistein Hovde5Magne Henriksen6Gert Huppertz-Hauss7Ole Hoie8Iril Kempski-Monstad9Inger Camilla Solberg10Njaal Stray11Jorgen Jahnsen12Bjorn Moum13R&D Department, Vestfold Hospital Trust, Tønsberg, Vestfold, NorwayUnger-Vetlesen Institute, Lovisenberg Diakonale Hospital, Oslo, NorwayDepartment of Gastroenterology, Akershus University Hospital, Lorenskog, NorwayDepartment of Gastroenterology, Oslo University Hospital, Oslo, NorwayDepartment of Gastroenterology, Oslo University Hospital, Oslo, NorwayFaculty of Medicine, Institute for Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Gastroenterology, Østfold Hospital Trust, Gralum, Kalnes, NorwayDepartment of Gastroenterology, Telemark Hospital, Ulefossveien, Skien, NorwayDepartment of Internal Medicine, Sørlandet Hospital, Sykehusveien, Arendal, NorwayDepartment of Internal Medicine, Lovisenberg Diakonale Hospital, Oslo, NorwayDepartment of Gastroenterology, Oslo University Hospital, Oslo, NorwayDepartment of Internal Medicine, Diakonhjemmet Hospital, Oslo, Norway2 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwayDepartment of Gastroenterology, Oslo University Hospital, Oslo, NorwayObjective The association between ulcerative colitis (UC) and colorectal cancer (CRC) is widely accepted, although attenuated risk has been reported in recent years. Colonoscopic surveillance is recommended with intervals based on established clinical risk factors. Nevertheless, a significant number of patients develop interval cancers, indicating the need of improved individualised assessment. In the present study, we evaluated clinical risk factors associated with CRC during a prescheduled follow-up 20 years after diagnosis, the IBSEN study.Design A population-based inception cohort of patients diagnosed with inflammatory bowel disease from 1 January 1990 until 31 December 1993, prospectively followed at 1, 5, 10 and 20 years after diagnosis. A total of 517 patients with UC were included; 264 (51 %) men; median age at inclusion 37.4 years (4–88).Results The overall incidence of CRC was 1.6% (8/517) at a 20-year follow-up. The total lifetime risk of CRC prior to or after UC diagnosis was 2.3%. (12/517). Patients older than 70 years at diagnosis had a 15-fold higher risk of CRC compared with those diagnosed when younger than 40 years, with HR 15.68 (95% CI: 1.31 to 187.92). Neither sex, first-degree relative with CRC, extent of colitis nor primary sclerosing cholangitis affected the risk of CRC.Conclusion The risk of CRC in UC was low and comparable with the risk of CRC in the background population of Norway.https://bmjopengastro.bmj.com/content/7/1/e000361.full |
| spellingShingle | Tomm Bernklev Pasquale Klepp Stephan Brackmann Milada Cvancarova Marte Lie Hoivik Øistein Hovde Magne Henriksen Gert Huppertz-Hauss Ole Hoie Iril Kempski-Monstad Inger Camilla Solberg Njaal Stray Jorgen Jahnsen Bjorn Moum Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study BMJ Open Gastroenterology |
| title | Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study |
| title_full | Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study |
| title_fullStr | Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study |
| title_full_unstemmed | Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study |
| title_short | Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study |
| title_sort | risk of colorectal cancer in a population based study 20 years after diagnosis of ulcerative colitis results from the ibsen study |
| url | https://bmjopengastro.bmj.com/content/7/1/e000361.full |
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