Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice
Food allergy is a significant public health concern globally. Certain probiotics have been found to enhance food allergy by regulating immune-microbe interactions in animal models and patients. However, the effects of Bifidobacterium lactis Probio-M8 on food allergy have not been thoroughly investig...
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Tsinghua University Press
2024-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250250 |
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| author | Jialu Shi Yan Xu Cheng Liu Shizhi Wang Jin Wang Vijaya Raghavan |
| author_facet | Jialu Shi Yan Xu Cheng Liu Shizhi Wang Jin Wang Vijaya Raghavan |
| author_sort | Jialu Shi |
| collection | DOAJ |
| description | Food allergy is a significant public health concern globally. Certain probiotics have been found to enhance food allergy by regulating immune-microbe interactions in animal models and patients. However, the effects of Bifidobacterium lactis Probio-M8 on food allergy have not been thoroughly investigated. The present study examined the anti-allergic properties of Probio-M8, particularly in relation to immune response and gut microbiota composition. Results demonstrate that oral administration of Probio-M8 effectively mitigated the allergy symptoms triggered by ovalbumin (OVA) by ameliorating the morphological damage in the jejunum, reducing OVA-specific IgE and histamine levels in the serum, and suppressing Th2 cytokines (interleukin (IL) 4 and IL-13) while increasing Th1 cytokines (interferon (IFN) γ) and regulatory T (Treg) cytokines (IL-10 and transforming growth factor (TGF) β1) in the culture supernatants of splenic cells. Furthermore, Probio-M8 effectively altered the diversity and composition of gut microbiota, particularly the relative abundances of Akkermansia_muciniphila in OVA-induced mice. Compared to the OVA group, the Probio-M8 group showed a decrease in the relative abundance of Akkermansia_muciniphila. In conclusion, Probio-M8 demonstrates the potential to alleviate food allergy by regulating the Th1/Th2 response and modulating gut microbiota, thereby offering a novel therapeutic strategy for patients with food allergy. |
| format | Article |
| id | doaj-art-b1a43757413e43bc88e6567d2e3c698c |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Tsinghua University Press |
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| series | Food Science and Human Wellness |
| spelling | doaj-art-b1a43757413e43bc88e6567d2e3c698c2025-01-10T06:56:48ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-07-011342346235210.26599/FSHW.2022.9250250Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in miceJialu Shi0Yan Xu1Cheng Liu2Shizhi Wang3Jin Wang4Vijaya Raghavan5Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering, Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering, Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering, Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering, Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaDepartment of Bioresource Engineering, Faculty of Agricultural and Environmental Sciences, McGill University, Sainte-Anne-de-Bellevue, QC H9X3V9, CanadaFood allergy is a significant public health concern globally. Certain probiotics have been found to enhance food allergy by regulating immune-microbe interactions in animal models and patients. However, the effects of Bifidobacterium lactis Probio-M8 on food allergy have not been thoroughly investigated. The present study examined the anti-allergic properties of Probio-M8, particularly in relation to immune response and gut microbiota composition. Results demonstrate that oral administration of Probio-M8 effectively mitigated the allergy symptoms triggered by ovalbumin (OVA) by ameliorating the morphological damage in the jejunum, reducing OVA-specific IgE and histamine levels in the serum, and suppressing Th2 cytokines (interleukin (IL) 4 and IL-13) while increasing Th1 cytokines (interferon (IFN) γ) and regulatory T (Treg) cytokines (IL-10 and transforming growth factor (TGF) β1) in the culture supernatants of splenic cells. Furthermore, Probio-M8 effectively altered the diversity and composition of gut microbiota, particularly the relative abundances of Akkermansia_muciniphila in OVA-induced mice. Compared to the OVA group, the Probio-M8 group showed a decrease in the relative abundance of Akkermansia_muciniphila. In conclusion, Probio-M8 demonstrates the potential to alleviate food allergy by regulating the Th1/Th2 response and modulating gut microbiota, thereby offering a novel therapeutic strategy for patients with food allergy.https://www.sciopen.com/article/10.26599/FSHW.2022.9250250food allergybifidobacterium lactis probio-m8t cell immune responsegut microbiota |
| spellingShingle | Jialu Shi Yan Xu Cheng Liu Shizhi Wang Jin Wang Vijaya Raghavan Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice Food Science and Human Wellness food allergy bifidobacterium lactis probio-m8 t cell immune response gut microbiota |
| title | Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice |
| title_full | Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice |
| title_fullStr | Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice |
| title_full_unstemmed | Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice |
| title_short | Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice |
| title_sort | preventive effects of bifidobacterium lactis probio m8 on ovalbumin induced food allergy in mice |
| topic | food allergy bifidobacterium lactis probio-m8 t cell immune response gut microbiota |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250250 |
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