A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases
This study aims to analyze the dynamics of Lassa fever transmission and its impact on the brain and spinal cord then devise and analyze preventive actions. The stability of the infection-free equilibrium point is evaluated; the model’s precision is examined using empirical data; and all parameters a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Mathematical and Computational Applications |
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| Online Access: | https://www.mdpi.com/2297-8747/29/6/102 |
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| author | Yasir Ramzan Hanadi Alzubadi Aziz Ullah Awan Kamel Guedri Mohammed Alharthi Bandar M. Fadhl |
| author_facet | Yasir Ramzan Hanadi Alzubadi Aziz Ullah Awan Kamel Guedri Mohammed Alharthi Bandar M. Fadhl |
| author_sort | Yasir Ramzan |
| collection | DOAJ |
| description | This study aims to analyze the dynamics of Lassa fever transmission and its impact on the brain and spinal cord then devise and analyze preventive actions. The stability of the infection-free equilibrium point is evaluated; the model’s precision is examined using empirical data; and all parameters are estimated and fitted. Subsequently, the basic reproductive number is determined, and subpopulation trends are observed over time. Sensitivity analysis is conducted to identify critical drivers influencing transmission dynamics. Two-dimensional plots visualize the impact of crucial parameters on the reproductive number. Through a comprehensive literature review and case analysis, an association between Lassa fever and various disabilities is established, including conditions such as encephalitis, hearing loss, ataxia, neuropsychiatric manifestations, meningitis, seizures, and coma. Solutions are devised and analyzed to enhance early detection, treatment, and mitigation of disease. |
| format | Article |
| id | doaj-art-b18f358ae54b4479876698ec2e08536a |
| institution | Kabale University |
| issn | 1300-686X 2297-8747 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Mathematical and Computational Applications |
| spelling | doaj-art-b18f358ae54b4479876698ec2e08536a2024-12-27T14:38:25ZengMDPI AGMathematical and Computational Applications1300-686X2297-87472024-11-0129610210.3390/mca29060102A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe CasesYasir Ramzan0Hanadi Alzubadi1Aziz Ullah Awan2Kamel Guedri3Mohammed Alharthi4Bandar M. Fadhl5Department of Mathematics, University of the Punjab, Lahore 54590, PakistanDepartment of Mathematics, Umm Al-Qura University, Makkah 24382, Saudi ArabiaDepartment of Mathematics, University of the Punjab, Lahore 54590, PakistanMechanical Engineering Department, College of Engineering and Architecture, Umm Al-Qura University, Makkah 21955, Saudi ArabiaDepartment of Mathematics, College of Sciences, University of Bisha, P.O. Box 344, Bisha 61922, Saudi ArabiaMechanical Engineering Department, College of Engineering and Architecture, Umm Al-Qura University, Makkah 21955, Saudi ArabiaThis study aims to analyze the dynamics of Lassa fever transmission and its impact on the brain and spinal cord then devise and analyze preventive actions. The stability of the infection-free equilibrium point is evaluated; the model’s precision is examined using empirical data; and all parameters are estimated and fitted. Subsequently, the basic reproductive number is determined, and subpopulation trends are observed over time. Sensitivity analysis is conducted to identify critical drivers influencing transmission dynamics. Two-dimensional plots visualize the impact of crucial parameters on the reproductive number. Through a comprehensive literature review and case analysis, an association between Lassa fever and various disabilities is established, including conditions such as encephalitis, hearing loss, ataxia, neuropsychiatric manifestations, meningitis, seizures, and coma. Solutions are devised and analyzed to enhance early detection, treatment, and mitigation of disease.https://www.mdpi.com/2297-8747/29/6/102mathematical applicationLassa virusdisabilitiesempirical datasensitivity analysisoptimal control |
| spellingShingle | Yasir Ramzan Hanadi Alzubadi Aziz Ullah Awan Kamel Guedri Mohammed Alharthi Bandar M. Fadhl A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases Mathematical and Computational Applications mathematical application Lassa virus disabilities empirical data sensitivity analysis optimal control |
| title | A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases |
| title_full | A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases |
| title_fullStr | A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases |
| title_full_unstemmed | A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases |
| title_short | A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases |
| title_sort | mathematical lens on the zoonotic transmission of lassa virus infections leading to disabilities in severe cases |
| topic | mathematical application Lassa virus disabilities empirical data sensitivity analysis optimal control |
| url | https://www.mdpi.com/2297-8747/29/6/102 |
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