The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development
In the past ten years, studies have shown the recognition of Trypanosoma cruzi-associated molecular patterns by members of the Toll-like receptor (TLR) family and demonstrated the crucial participation of different TLRs during the experimental infection with this parasite. In the present review, we...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2012/507874 |
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| _version_ | 1841524884825440256 |
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| author | Mauricio M. Rodrigues Ana Carolina Oliveira Maria Bellio |
| author_facet | Mauricio M. Rodrigues Ana Carolina Oliveira Maria Bellio |
| author_sort | Mauricio M. Rodrigues |
| collection | DOAJ |
| description | In the past ten years, studies have shown the recognition of Trypanosoma cruzi-associated molecular patterns by members of the Toll-like receptor (TLR) family and demonstrated the crucial participation of different TLRs during the experimental infection with this parasite. In the present review, we will focus on the role of TLR-activated pathways in the modulation of both innate and acquired immune responses to T. cruzi infection, as well as discuss the state of the art of vaccine research and development against the causative agent of Chagas disease (or American trypanosomiasis). |
| format | Article |
| id | doaj-art-b18af4ecd1004af98956eab7044469fc |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-b18af4ecd1004af98956eab7044469fc2025-02-03T05:47:11ZengWileyJournal of Parasitology Research2090-00232090-00312012-01-01201210.1155/2012/507874507874The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine DevelopmentMauricio M. Rodrigues0Ana Carolina Oliveira1Maria Bellio2Centro de Terapia Celular e Molecular (CTCMol), Universidade Federal de São Paulo (UNIFESP), 04044-010 São Paulo, SP, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), 21941-902 Rio de Janeiro, RJ, BrazilInstituto de Microbiologia Paulo de Góes, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro (UFRJ), CCS, Avenida Carlos Chagas Filho, 373 Bloco D, sala 35, Cidade Universitária, 21941-902 Rio de Janeiro, RJ, BrazilIn the past ten years, studies have shown the recognition of Trypanosoma cruzi-associated molecular patterns by members of the Toll-like receptor (TLR) family and demonstrated the crucial participation of different TLRs during the experimental infection with this parasite. In the present review, we will focus on the role of TLR-activated pathways in the modulation of both innate and acquired immune responses to T. cruzi infection, as well as discuss the state of the art of vaccine research and development against the causative agent of Chagas disease (or American trypanosomiasis).http://dx.doi.org/10.1155/2012/507874 |
| spellingShingle | Mauricio M. Rodrigues Ana Carolina Oliveira Maria Bellio The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development Journal of Parasitology Research |
| title | The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development |
| title_full | The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development |
| title_fullStr | The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development |
| title_full_unstemmed | The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development |
| title_short | The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development |
| title_sort | immune response to trypanosoma cruzi role of toll like receptors and perspectives for vaccine development |
| url | http://dx.doi.org/10.1155/2012/507874 |
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