Follicular T cells and the control of IgE responses
Atopy is considered the epidemic of the 21st century, and while decades of research have established a direct link between Th2 cells driving pathogenic IgE-mediated allergic disease, only in the past years have T follicular helper (Tfh) cells emerged as pivotal drivers of these responses. In this re...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Allergology International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893024001151 |
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| author | Pablo F. Cañete Di Yu |
| author_facet | Pablo F. Cañete Di Yu |
| author_sort | Pablo F. Cañete |
| collection | DOAJ |
| description | Atopy is considered the epidemic of the 21st century, and while decades of research have established a direct link between Th2 cells driving pathogenic IgE-mediated allergic disease, only in the past years have T follicular helper (Tfh) cells emerged as pivotal drivers of these responses. In this review, we will examine the molecular mechanisms governing the IgE response, with a particular emphasis on the key cytokines and signaling pathways. We will discuss the exclusion of IgE-producing B cells from germinal centers and explore the recently established role of follicular T cell function and heterogeneity in driving or curtailing these immune responses. Additionally, we will assess the current state of major monoclonal antibodies and allergen immunotherapies designed to counteract Th2-driven inflammation, as well as reflect on the need to investigate how these biologics impact Tfh cell activity, differentiation, and function, as these insights could pave the way for much-needed therapeutic innovation in the treatment of allergic diseases. |
| format | Article |
| id | doaj-art-b1500efdb80045b09abf6182d15d23e6 |
| institution | Kabale University |
| issn | 1323-8930 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj-art-b1500efdb80045b09abf6182d15d23e62025-01-04T04:56:08ZengElsevierAllergology International1323-89302025-01-017411319Follicular T cells and the control of IgE responsesPablo F. Cañete0Di Yu1Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Corresponding author. Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Corresponding author. Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.Atopy is considered the epidemic of the 21st century, and while decades of research have established a direct link between Th2 cells driving pathogenic IgE-mediated allergic disease, only in the past years have T follicular helper (Tfh) cells emerged as pivotal drivers of these responses. In this review, we will examine the molecular mechanisms governing the IgE response, with a particular emphasis on the key cytokines and signaling pathways. We will discuss the exclusion of IgE-producing B cells from germinal centers and explore the recently established role of follicular T cell function and heterogeneity in driving or curtailing these immune responses. Additionally, we will assess the current state of major monoclonal antibodies and allergen immunotherapies designed to counteract Th2-driven inflammation, as well as reflect on the need to investigate how these biologics impact Tfh cell activity, differentiation, and function, as these insights could pave the way for much-needed therapeutic innovation in the treatment of allergic diseases.http://www.sciencedirect.com/science/article/pii/S1323893024001151AllergyFollicular T cellsIgETfh cellsTfr cells |
| spellingShingle | Pablo F. Cañete Di Yu Follicular T cells and the control of IgE responses Allergology International Allergy Follicular T cells IgE Tfh cells Tfr cells |
| title | Follicular T cells and the control of IgE responses |
| title_full | Follicular T cells and the control of IgE responses |
| title_fullStr | Follicular T cells and the control of IgE responses |
| title_full_unstemmed | Follicular T cells and the control of IgE responses |
| title_short | Follicular T cells and the control of IgE responses |
| title_sort | follicular t cells and the control of ige responses |
| topic | Allergy Follicular T cells IgE Tfh cells Tfr cells |
| url | http://www.sciencedirect.com/science/article/pii/S1323893024001151 |
| work_keys_str_mv | AT pablofcanete folliculartcellsandthecontrolofigeresponses AT diyu folliculartcellsandthecontrolofigeresponses |