Royal Jelly and 10-Hydroxy-2-Decenoic acid activate autophagy through mTOR/ULK1 pathway to improve cognitive function in diabetic mice
Diabetes, a ruthless chronic metabolic disorder, is increasingly considered to jeopardize global well-being over the decades. Royal jelly (RJ) is a complex natural product secreted by worker bees containing a unique fatty acid known as 10-hydroxy-2-decenoic acid (10-HDA). This study aimed to verify...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006522 |
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| author | Lu Xiu Rongguang Ge Siyu Lu Linwei Li Wenqi Huang Guojun Du Zengli Zhang Jie Zhang Zhongxiao Wan Jie Chang |
| author_facet | Lu Xiu Rongguang Ge Siyu Lu Linwei Li Wenqi Huang Guojun Du Zengli Zhang Jie Zhang Zhongxiao Wan Jie Chang |
| author_sort | Lu Xiu |
| collection | DOAJ |
| description | Diabetes, a ruthless chronic metabolic disorder, is increasingly considered to jeopardize global well-being over the decades. Royal jelly (RJ) is a complex natural product secreted by worker bees containing a unique fatty acid known as 10-hydroxy-2-decenoic acid (10-HDA). This study aimed to verify the protective effect on cognitive function of RJ and 10-HDA in diabetic mice and explore the underlying mechanism. Briefly, our animal experiment results suggested that 10-HDA had a significant hypoglycemic effect and improved cognitive performance. Through western blotting, RJ and 10-HDA intervention notably increased Atg7, Atg16L1, Beclin-1, Atg5, Atg12, Atg3, and LC3-II expression and decreased p62 expression. Meanwhile, decreased mTOR expression and increased ULK1 expression were also observed in the 10-HDA intervention group. In conclusion, 10-HDA can regulate mTOR/ULK1 pathway to activate autophagy to alleviate hippocampal damage, thereby improving cognitive function in mice with diabetes, which may provide a new option for real-world cognitive impairment management. |
| format | Article |
| id | doaj-art-b14c3c36e4164a2e96a8cdce531018a5 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-b14c3c36e4164a2e96a8cdce531018a52025-01-12T05:24:47ZengElsevierJournal of Functional Foods1756-46462025-01-01124106649Royal Jelly and 10-Hydroxy-2-Decenoic acid activate autophagy through mTOR/ULK1 pathway to improve cognitive function in diabetic miceLu Xiu0Rongguang Ge1Siyu Lu2Linwei Li3Wenqi Huang4Guojun Du5Zengli Zhang6Jie Zhang7Zhongxiao Wan8Jie Chang9School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.; Department of Neurology and Clinical Research Centre of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaSchool of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-Communicable Diseases, Suzhou Medical College of Soochow University, Suzhou, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, China; Corresponding author at: School of Public Health, Suzhou Medical College of Soochow University, Soochow University, 199 Renai Road, Suzhou, 215123, China.Diabetes, a ruthless chronic metabolic disorder, is increasingly considered to jeopardize global well-being over the decades. Royal jelly (RJ) is a complex natural product secreted by worker bees containing a unique fatty acid known as 10-hydroxy-2-decenoic acid (10-HDA). This study aimed to verify the protective effect on cognitive function of RJ and 10-HDA in diabetic mice and explore the underlying mechanism. Briefly, our animal experiment results suggested that 10-HDA had a significant hypoglycemic effect and improved cognitive performance. Through western blotting, RJ and 10-HDA intervention notably increased Atg7, Atg16L1, Beclin-1, Atg5, Atg12, Atg3, and LC3-II expression and decreased p62 expression. Meanwhile, decreased mTOR expression and increased ULK1 expression were also observed in the 10-HDA intervention group. In conclusion, 10-HDA can regulate mTOR/ULK1 pathway to activate autophagy to alleviate hippocampal damage, thereby improving cognitive function in mice with diabetes, which may provide a new option for real-world cognitive impairment management.http://www.sciencedirect.com/science/article/pii/S1756464624006522AutophagyCognitive dysfunctionDiabetesRoyal Jelly10-HDA |
| spellingShingle | Lu Xiu Rongguang Ge Siyu Lu Linwei Li Wenqi Huang Guojun Du Zengli Zhang Jie Zhang Zhongxiao Wan Jie Chang Royal Jelly and 10-Hydroxy-2-Decenoic acid activate autophagy through mTOR/ULK1 pathway to improve cognitive function in diabetic mice Journal of Functional Foods Autophagy Cognitive dysfunction Diabetes Royal Jelly 10-HDA |
| title | Royal Jelly and 10-Hydroxy-2-Decenoic acid activate autophagy through mTOR/ULK1 pathway to improve cognitive function in diabetic mice |
| title_full | Royal Jelly and 10-Hydroxy-2-Decenoic acid activate autophagy through mTOR/ULK1 pathway to improve cognitive function in diabetic mice |
| title_fullStr | Royal Jelly and 10-Hydroxy-2-Decenoic acid activate autophagy through mTOR/ULK1 pathway to improve cognitive function in diabetic mice |
| title_full_unstemmed | Royal Jelly and 10-Hydroxy-2-Decenoic acid activate autophagy through mTOR/ULK1 pathway to improve cognitive function in diabetic mice |
| title_short | Royal Jelly and 10-Hydroxy-2-Decenoic acid activate autophagy through mTOR/ULK1 pathway to improve cognitive function in diabetic mice |
| title_sort | royal jelly and 10 hydroxy 2 decenoic acid activate autophagy through mtor ulk1 pathway to improve cognitive function in diabetic mice |
| topic | Autophagy Cognitive dysfunction Diabetes Royal Jelly 10-HDA |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006522 |
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