p97 Inhibitors Possessing Antiviral Activity Against SARS-CoV-2 and Low Cytotoxicity

p97 Inhibitors Possessing Antiviral Activity Against SARS-CoV-2 and Low Cytotoxicity

<b>Background:</b> p97 (also known as valosin-containing protein, VCP) is a member of the AAA+ ATPase family and is intimately associated with protein quality control and homeostasis regulation. Therefore, pharmaceutical inhibition of p97 has been actively pursued as an anticancer strate...

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Bibliographic Details
Main Authors: Rui Ding, Tiffany C. Edwards, Prithwish Goswami, Daniel J. Wilson, Christine D. Dreis, Yihong Ye, Robert J. Geraghty, Liqiang Chen
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Pharmaceuticals
Subjects:
p97
p97 inhibitor
antiviral
SARS-CoV-2
coronavirus
Online Access:https://www.mdpi.com/1424-8247/18/1/131
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