Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting

Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting

Abstract Fibrinolysis influences the mobilization of hematopoietic stem cells from their bone marrow microenvironment (BMM). Here we show that activation of plasmin, a key fibrinolytic agent, by annexin A2 (ANXA2) distinctly impacts progression of BCR-ABL1+ B-cell acute lymphoblastic leukemia (B-ALL...

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Main Authors: Valentina R. Minciacchi, Jimena Bravo, Christina Karantanou, Raquel S. Pereira, Costanza Zanetti, Rahul Kumar, Nathalie Thomasberger, Pablo Llavona, Theresa Krack, Katrin Bankov, Melanie Meister, Sylvia Hartmann, Véronique Maguer-Satta, Sylvain Lefort, Mateusz Putyrski, Andreas Ernst, Brian J. P. Huntly, Eshwar Meduri, Wolfram Ruf, Daniela S. Krause
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54361-4
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