Prospective evaluation of septic shock patients in a tertiary care educational university hospital: a series of 1892 cases
AIM: We aimed to evaluate the septic shock(SS) cases in terms of mortality and effecting variables for outcomes. BACKGROUND: Despite advancements and the early implementation of targeted therapies,sepsis-related mortality remains high. METHODS: Patients who had SS and consulted to Infectious Disease...
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524003448 |
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| author | Gamze Şanlıdağ Işbilen Deniz Akyol Seyhan Merve Mert Vahabi Buse Kenanoğlu Dilşah Başkol Elik Seichan Ketentzi Oğuzhan Acet Nazlihan Yalçin Cansu Bulut Avşar Ayşe Öna Arda Kaya Şükrü Dirik Uğur Öna Buğra Özkar Damla Akdağ Derya Kaya Gunel Guliyeva Cansu Tol Meltem Ceylan Gökhan Vatansever Melike Demir Serhat Uysal Hilal Sipahi Şöhret Aydemir Meltem Taşbakan Bilgin Arda Oğuz Reşat Sipahi |
| author_facet | Gamze Şanlıdağ Işbilen Deniz Akyol Seyhan Merve Mert Vahabi Buse Kenanoğlu Dilşah Başkol Elik Seichan Ketentzi Oğuzhan Acet Nazlihan Yalçin Cansu Bulut Avşar Ayşe Öna Arda Kaya Şükrü Dirik Uğur Öna Buğra Özkar Damla Akdağ Derya Kaya Gunel Guliyeva Cansu Tol Meltem Ceylan Gökhan Vatansever Melike Demir Serhat Uysal Hilal Sipahi Şöhret Aydemir Meltem Taşbakan Bilgin Arda Oğuz Reşat Sipahi |
| author_sort | Gamze Şanlıdağ Işbilen |
| collection | DOAJ |
| description | AIM: We aimed to evaluate the septic shock(SS) cases in terms of mortality and effecting variables for outcomes. BACKGROUND: Despite advancements and the early implementation of targeted therapies,sepsis-related mortality remains high. METHODS: Patients who had SS and consulted to Infectious Diseases between December 2013-September 2023 in our center were followed-up prospectively.Arterial lactate level 2 mg/dL criterion was added as an including criteria for SS according to the latest guidelines.Statistical analysis was performed via Chi-square test, a p value<0.05 was considered significant.Neutropenic(<500/mm3) cases were excluded. RESULTS: There were a total of 1892 patients(mean age 66.85±15.18 years and 41.75% female).1057(55.87%) patients in non-hospital acqurieed(admitted with SS or SS developed in less than 48h)(NHASS),835(44.13%) patients in hospital SS(HASS) group fulfilled the study criteria.Mean CRP,leukocyte count,procalcitonin levels were 15.26±11.68 mg/dl,17023±15347/mm3 and 20.77±31.04 µg/l.Arterial lactate level was available in 1534 cases(mean:5.89±4.84 mg/dl). The most common infection sites were pneumonia(n:797-39%) followed by intraabdominal infection(n:428-22.6%) and urinary tract infection(UTI-n:315-16.6%).Microbiological etiology was elucidated in(n:934-49.4%)cases. The most common pathogens were 223 E.coli(%67.8 ESBL+),203 Klebsiella spp.(57.6% carbapenem-resistant),149(7.9%) yeasts and 146 Acinetobacter spp.(91.1% carbapenem-resistant).In 318(34.04%) of 934 cases,>1 pathogen were isolated.One month mortality(OMM) in overall cohort was 76.64% and significantly higher than UTI or intraabdominal infection in the pneumonia SS subgroup(Table,p=0.027).OMM was higher in HASS than in NHASS[79.04%vs.74.64%,p:024].OMM with proven etiology and others were[75.8%vs.77.34%,p:0.427].OMM was significantly higher in lactate>2 subgroup(Table,p<0.001) and in those antibiotics could be started >1 h after the start of the antibiotics(Table,p<0.014). CONCLUSIONS: The worst outcomes were in pneumonia subgroup.We need more efficient diagnostic as well as and therapeutic tools to decrease the significant mortality. |
| format | Article |
| id | doaj-art-b0ebdcfeaccf4e898efb468d5fad83c8 |
| institution | Kabale University |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-b0ebdcfeaccf4e898efb468d5fad83c82024-12-27T04:08:40ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-01395253Prospective evaluation of septic shock patients in a tertiary care educational university hospital: a series of 1892 casesGamze Şanlıdağ Işbilen0Deniz Akyol Seyhan1Merve Mert Vahabi2Buse Kenanoğlu3Dilşah Başkol Elik4Seichan Ketentzi5Oğuzhan Acet6Nazlihan Yalçin7Cansu Bulut Avşar8Ayşe Öna9Arda Kaya10Şükrü Dirik11Uğur Öna12Buğra Özkar13Damla Akdağ14Derya Kaya15Gunel Guliyeva16Cansu Tol17Meltem Ceylan18Gökhan Vatansever19Melike Demir20Serhat Uysal21Hilal Sipahi22Şöhret Aydemir23Meltem Taşbakan24Bilgin Arda25Oğuz Reşat Sipahi26Deparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, TurkeyDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Yüksek İhtisas Research and Teaching Hospital, Bursa, TurkeyDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Uludağ University, Bursa, TurkeyDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Liv Bona Dea Hospital, Baku, AzerbaijanDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Fırat University, Elazıg, TurkeyBornova Directory of Health, Izmir, TurkeyDeparment of Microbiology, Ege University, Izmir, TurkeyDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeDeparment of Infectious Diseases and Clinical Microbiology, Ege University, Izmir, TürkiyeAIM: We aimed to evaluate the septic shock(SS) cases in terms of mortality and effecting variables for outcomes. BACKGROUND: Despite advancements and the early implementation of targeted therapies,sepsis-related mortality remains high. METHODS: Patients who had SS and consulted to Infectious Diseases between December 2013-September 2023 in our center were followed-up prospectively.Arterial lactate level 2 mg/dL criterion was added as an including criteria for SS according to the latest guidelines.Statistical analysis was performed via Chi-square test, a p value<0.05 was considered significant.Neutropenic(<500/mm3) cases were excluded. RESULTS: There were a total of 1892 patients(mean age 66.85±15.18 years and 41.75% female).1057(55.87%) patients in non-hospital acqurieed(admitted with SS or SS developed in less than 48h)(NHASS),835(44.13%) patients in hospital SS(HASS) group fulfilled the study criteria.Mean CRP,leukocyte count,procalcitonin levels were 15.26±11.68 mg/dl,17023±15347/mm3 and 20.77±31.04 µg/l.Arterial lactate level was available in 1534 cases(mean:5.89±4.84 mg/dl). The most common infection sites were pneumonia(n:797-39%) followed by intraabdominal infection(n:428-22.6%) and urinary tract infection(UTI-n:315-16.6%).Microbiological etiology was elucidated in(n:934-49.4%)cases. The most common pathogens were 223 E.coli(%67.8 ESBL+),203 Klebsiella spp.(57.6% carbapenem-resistant),149(7.9%) yeasts and 146 Acinetobacter spp.(91.1% carbapenem-resistant).In 318(34.04%) of 934 cases,>1 pathogen were isolated.One month mortality(OMM) in overall cohort was 76.64% and significantly higher than UTI or intraabdominal infection in the pneumonia SS subgroup(Table,p=0.027).OMM was higher in HASS than in NHASS[79.04%vs.74.64%,p:024].OMM with proven etiology and others were[75.8%vs.77.34%,p:0.427].OMM was significantly higher in lactate>2 subgroup(Table,p<0.001) and in those antibiotics could be started >1 h after the start of the antibiotics(Table,p<0.014). CONCLUSIONS: The worst outcomes were in pneumonia subgroup.We need more efficient diagnostic as well as and therapeutic tools to decrease the significant mortality.http://www.sciencedirect.com/science/article/pii/S2213716524003448septic shocksespismortality |
| spellingShingle | Gamze Şanlıdağ Işbilen Deniz Akyol Seyhan Merve Mert Vahabi Buse Kenanoğlu Dilşah Başkol Elik Seichan Ketentzi Oğuzhan Acet Nazlihan Yalçin Cansu Bulut Avşar Ayşe Öna Arda Kaya Şükrü Dirik Uğur Öna Buğra Özkar Damla Akdağ Derya Kaya Gunel Guliyeva Cansu Tol Meltem Ceylan Gökhan Vatansever Melike Demir Serhat Uysal Hilal Sipahi Şöhret Aydemir Meltem Taşbakan Bilgin Arda Oğuz Reşat Sipahi Prospective evaluation of septic shock patients in a tertiary care educational university hospital: a series of 1892 cases Journal of Global Antimicrobial Resistance septic shock sespis mortality |
| title | Prospective evaluation of septic shock patients in a tertiary care educational university hospital: a series of 1892 cases |
| title_full | Prospective evaluation of septic shock patients in a tertiary care educational university hospital: a series of 1892 cases |
| title_fullStr | Prospective evaluation of septic shock patients in a tertiary care educational university hospital: a series of 1892 cases |
| title_full_unstemmed | Prospective evaluation of septic shock patients in a tertiary care educational university hospital: a series of 1892 cases |
| title_short | Prospective evaluation of septic shock patients in a tertiary care educational university hospital: a series of 1892 cases |
| title_sort | prospective evaluation of septic shock patients in a tertiary care educational university hospital a series of 1892 cases |
| topic | septic shock sespis mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524003448 |
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