Natural history of non-neovascular pigment epithelial detachments (PEDs): Comparison between serous and drusenoid PEDs
Purpose: To describe the long-term natural history of non-neovascular pigment epithelial detachments (nnPEDs), by comparing the multimodal imaging features of either serous or drusenoid PEDs (SPED and DPED) in patients with age-related macular degeneration. Methods: Eyes with nnPEDs > 700 μm in w...
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Elsevier
2025-04-01
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| Series: | AJO International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950253525000036 |
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| author | Mathilde M. Goudot Eric H. Souied Donato Colantuono Camille Jung Carl-Joe Mehanna Benjamin Memmi Giuseppe Querques Salomon-Yves Cohen Alexandra Miere |
| author_facet | Mathilde M. Goudot Eric H. Souied Donato Colantuono Camille Jung Carl-Joe Mehanna Benjamin Memmi Giuseppe Querques Salomon-Yves Cohen Alexandra Miere |
| author_sort | Mathilde M. Goudot |
| collection | DOAJ |
| description | Purpose: To describe the long-term natural history of non-neovascular pigment epithelial detachments (nnPEDs), by comparing the multimodal imaging features of either serous or drusenoid PEDs (SPED and DPED) in patients with age-related macular degeneration. Methods: Eyes with nnPEDs > 700 μm in width and a height > 150 μm on spectral domain optical coherence tomography (SD-OCT), with at least 12 months follow-up, were included. SPED and DPED were distinguished. SD-OCT qualitative and quantitative variables were compared at baseline, at the time of maximal PED height, and at the final visit. Results: Forty-seven eyes of 31 patients were followed for 69 ± 35 months (mean age 68 ± 7.2 years): 27 eyes in the DPED group and 20 eyes in the SPED group. SPEDs were significantly higher and wider than DPEDs at the maximal PED height visit (p = 0.007 and p = 0.023, respectively). More apertures (p = 0.007), i.e., sharply demarcated discontinuities of the PED, and lateral subretinal fluid (p = 0.008) were observed in SPEDs. There was no significant difference between the two groups in the qualitative analysis or in the evolution over time. Ten eyes (50 %) with SPEDs and 11 eyes (41 %) with DPEDs (p = 0.46) progressed toward geographic atrophy, and 4 eyes (20 %) with SPEDs and 3 eyes (11 %) with DPEDs (p = 0.68) progressed toward fibrosis. Conclusion: This analysis of large nnPEDs revealed that large PEDs pose a high risk of complications regardless of their nature. |
| format | Article |
| id | doaj-art-b0e9e0136cb84154b49673b9c34587a5 |
| institution | Kabale University |
| issn | 2950-2535 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AJO International |
| spelling | doaj-art-b0e9e0136cb84154b49673b9c34587a52025-01-12T05:26:23ZengElsevierAJO International2950-25352025-04-0121100100Natural history of non-neovascular pigment epithelial detachments (PEDs): Comparison between serous and drusenoid PEDsMathilde M. Goudot0Eric H. Souied1Donato Colantuono2Camille Jung3Carl-Joe Mehanna4Benjamin Memmi5Giuseppe Querques6Salomon-Yves Cohen7Alexandra Miere8Department of Ophthalmology, Intercity Hospital of Créteil, University Paris Est, 40 Avenue de Verdun, Créteil 94000, FranceDepartment of Ophthalmology, Intercity Hospital of Créteil, University Paris Est, 40 Avenue de Verdun, Créteil 94000, FranceDepartment of Ophthalmology, Intercity Hospital of Créteil, University Paris Est, 40 Avenue de Verdun, Créteil 94000, FranceClinical Research Center, Intercity Hospital of Créteil, University Paris Est, Créteil, FranceDepartment of Ophthalmology, Intercity Hospital of Créteil, University Paris Est, 40 Avenue de Verdun, Créteil 94000, FranceDepartment of Ophthalmology, Intercity Hospital of Créteil, University Paris Est, 40 Avenue de Verdun, Créteil 94000, FranceDepartment of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, ItalyDepartment of Ophthalmology, Intercity Hospital of Créteil, University Paris Est, 40 Avenue de Verdun, Créteil 94000, France; Ophthalmic Center for Imaging and Laser, Paris, FranceDepartment of Ophthalmology, Intercity Hospital of Créteil, University Paris Est, 40 Avenue de Verdun, Créteil 94000, France; Corresponding author.Purpose: To describe the long-term natural history of non-neovascular pigment epithelial detachments (nnPEDs), by comparing the multimodal imaging features of either serous or drusenoid PEDs (SPED and DPED) in patients with age-related macular degeneration. Methods: Eyes with nnPEDs > 700 μm in width and a height > 150 μm on spectral domain optical coherence tomography (SD-OCT), with at least 12 months follow-up, were included. SPED and DPED were distinguished. SD-OCT qualitative and quantitative variables were compared at baseline, at the time of maximal PED height, and at the final visit. Results: Forty-seven eyes of 31 patients were followed for 69 ± 35 months (mean age 68 ± 7.2 years): 27 eyes in the DPED group and 20 eyes in the SPED group. SPEDs were significantly higher and wider than DPEDs at the maximal PED height visit (p = 0.007 and p = 0.023, respectively). More apertures (p = 0.007), i.e., sharply demarcated discontinuities of the PED, and lateral subretinal fluid (p = 0.008) were observed in SPEDs. There was no significant difference between the two groups in the qualitative analysis or in the evolution over time. Ten eyes (50 %) with SPEDs and 11 eyes (41 %) with DPEDs (p = 0.46) progressed toward geographic atrophy, and 4 eyes (20 %) with SPEDs and 3 eyes (11 %) with DPEDs (p = 0.68) progressed toward fibrosis. Conclusion: This analysis of large nnPEDs revealed that large PEDs pose a high risk of complications regardless of their nature.http://www.sciencedirect.com/science/article/pii/S2950253525000036Age-related macular degenerationNon-neovascular pigment epithelial detachmentSpectral domain optical coherence tomography |
| spellingShingle | Mathilde M. Goudot Eric H. Souied Donato Colantuono Camille Jung Carl-Joe Mehanna Benjamin Memmi Giuseppe Querques Salomon-Yves Cohen Alexandra Miere Natural history of non-neovascular pigment epithelial detachments (PEDs): Comparison between serous and drusenoid PEDs AJO International Age-related macular degeneration Non-neovascular pigment epithelial detachment Spectral domain optical coherence tomography |
| title | Natural history of non-neovascular pigment epithelial detachments (PEDs): Comparison between serous and drusenoid PEDs |
| title_full | Natural history of non-neovascular pigment epithelial detachments (PEDs): Comparison between serous and drusenoid PEDs |
| title_fullStr | Natural history of non-neovascular pigment epithelial detachments (PEDs): Comparison between serous and drusenoid PEDs |
| title_full_unstemmed | Natural history of non-neovascular pigment epithelial detachments (PEDs): Comparison between serous and drusenoid PEDs |
| title_short | Natural history of non-neovascular pigment epithelial detachments (PEDs): Comparison between serous and drusenoid PEDs |
| title_sort | natural history of non neovascular pigment epithelial detachments peds comparison between serous and drusenoid peds |
| topic | Age-related macular degeneration Non-neovascular pigment epithelial detachment Spectral domain optical coherence tomography |
| url | http://www.sciencedirect.com/science/article/pii/S2950253525000036 |
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