Targeting the CD39/CD73 pathway: New insights into cardiac fibrosis and inflammation in female cardiac surgery patients

Targeting the CD39/CD73 pathway: New insights into cardiac fibrosis and inflammation in female cardiac surgery patients

Women undergoing cardiac surgery suffer from worse outcomes than their male counterparts. The reasons for this disparity are multifactorial, but the loss of the protective effects of estrogen likely plays a role. Estrogen acts on the CD39/CD73 purine pathway, and loss of estrogen effects may contrib...

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Bibliographic Details
Main Authors: Eitezaz Mahmood, Mark Robitaille, Yifan Bu, Adnan Khan, Marie-France Poulin, Feroze Mahmood, Ruma Bose, Kamal R. Khabbaz, Simon C. Robson, Robina Matyal
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
CD39
CD73
Cardiac surgery
Apyrase
Fibrosis
Diastolic function
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976125000133
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