Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma
Multiple Myeloma (MM) is the second most common malignancy of the hematopoietic system, accounting for approximately 10% of all hematological malignancies, and currently, there is no complete cure. Existing research indicates that exosomal long non-coding RNAs (lncRNAs) play a crucial regulatory rol...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1522491/full |
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| author | Hong Yan Nan Jiang Xiaoying Li Chenyang Lin Fang Wang Juan Zhang Lijuan Chen Dan Li |
| author_facet | Hong Yan Nan Jiang Xiaoying Li Chenyang Lin Fang Wang Juan Zhang Lijuan Chen Dan Li |
| author_sort | Hong Yan |
| collection | DOAJ |
| description | Multiple Myeloma (MM) is the second most common malignancy of the hematopoietic system, accounting for approximately 10% of all hematological malignancies, and currently, there is no complete cure. Existing research indicates that exosomal long non-coding RNAs (lncRNAs) play a crucial regulatory role in the initiation and progression of tumors, involving various interactions such as lncRNA-miRNA, lncRNA-mRNA, and lncRNA-RNA binding proteins (RBP). Despite the significant clinical application potential of exosomal lncRNAs, research in this area still faces challenges due to their low abundance and technical limitations. To our knowledge, this review is the first to comprehensively integrate and elucidate the three mechanisms of action of exosomal lncRNAs in MM, and to propose potential therapeutic targets and clinical cases based on these mechanisms. We highlight the latest advancements in the potential of exosomal lncRNAs as biomarkers and therapeutic targets, offering not only a comprehensive analysis of the role of exosomal lncRNAs in MM but also new perspectives and methods for future clinical diagnosis and treatment of multiple myeloma. |
| format | Article |
| id | doaj-art-b0d436cbec3948d99132849c37bc88ce |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-b0d436cbec3948d99132849c37bc88ce2025-01-16T06:10:19ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15224911522491Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myelomaHong Yan0Nan Jiang1Xiaoying Li2Chenyang Lin3Fang Wang4Juan Zhang5Lijuan Chen6Dan Li7School of Laboratory Medicine, Chengdu Medical College, Chengdu, Sichuan, ChinaSchool of Laboratory Medicine, Chengdu Medical College, Chengdu, Sichuan, ChinaSchool of Laboratory Medicine, Chengdu Medical College, Chengdu, Sichuan, ChinaSchool of Laboratory Medicine, Chengdu Medical College, Chengdu, Sichuan, ChinaSchool of Dental Medicine, Dalian University, Dalian, Liaoning, ChinaDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Hematopathology, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, ChinaSchool of Laboratory Medicine, Chengdu Medical College, Chengdu, Sichuan, ChinaMultiple Myeloma (MM) is the second most common malignancy of the hematopoietic system, accounting for approximately 10% of all hematological malignancies, and currently, there is no complete cure. Existing research indicates that exosomal long non-coding RNAs (lncRNAs) play a crucial regulatory role in the initiation and progression of tumors, involving various interactions such as lncRNA-miRNA, lncRNA-mRNA, and lncRNA-RNA binding proteins (RBP). Despite the significant clinical application potential of exosomal lncRNAs, research in this area still faces challenges due to their low abundance and technical limitations. To our knowledge, this review is the first to comprehensively integrate and elucidate the three mechanisms of action of exosomal lncRNAs in MM, and to propose potential therapeutic targets and clinical cases based on these mechanisms. We highlight the latest advancements in the potential of exosomal lncRNAs as biomarkers and therapeutic targets, offering not only a comprehensive analysis of the role of exosomal lncRNAs in MM but also new perspectives and methods for future clinical diagnosis and treatment of multiple myeloma.https://www.frontiersin.org/articles/10.3389/fonc.2024.1522491/fulllncRNAceRNAexosomesmultiple myelomabiological markersdsRNA |
| spellingShingle | Hong Yan Nan Jiang Xiaoying Li Chenyang Lin Fang Wang Juan Zhang Lijuan Chen Dan Li Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma Frontiers in Oncology lncRNA ceRNA exosomes multiple myeloma biological markers dsRNA |
| title | Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma |
| title_full | Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma |
| title_fullStr | Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma |
| title_full_unstemmed | Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma |
| title_short | Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma |
| title_sort | exosomal lncrnas as diagnostic and therapeutic targets in multiple myeloma |
| topic | lncRNA ceRNA exosomes multiple myeloma biological markers dsRNA |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1522491/full |
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