Polymer-based antimicrobial strategies for periodontitis
Periodontitis is a chronic inflammatory condition driven by plaque-associated microorganisms, where uncontrolled bacterial invasion and proliferation impair host immune responses, leading to localized periodontal tissue inflammation and bone destruction. Conventional periodontal therapies face chall...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1533964/full |
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| author | Jiajia Chen Shujun Dong |
| author_facet | Jiajia Chen Shujun Dong |
| author_sort | Jiajia Chen |
| collection | DOAJ |
| description | Periodontitis is a chronic inflammatory condition driven by plaque-associated microorganisms, where uncontrolled bacterial invasion and proliferation impair host immune responses, leading to localized periodontal tissue inflammation and bone destruction. Conventional periodontal therapies face challenges, including incomplete microbial clearance and the rise of antibiotic resistance, limiting their precision and effectiveness in managing periodontitis. Recently, nanotherapies based on polymeric materials have introduced advanced approaches to periodontal antimicrobial therapy through diverse antimicrobial mechanisms. This review explored specific mechanisms, emphasizing the design of polymer-based agents that employ individual or synergistic antimicrobial actions, and evaluated the innovations and limitations of current strategies while forecasting future trends in antimicrobial development for periodontitis. |
| format | Article |
| id | doaj-art-b0c5296c09c248f49ed2bbfbaa8cf7f7 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-b0c5296c09c248f49ed2bbfbaa8cf7f72025-01-06T06:59:04ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15339641533964Polymer-based antimicrobial strategies for periodontitisJiajia ChenShujun DongPeriodontitis is a chronic inflammatory condition driven by plaque-associated microorganisms, where uncontrolled bacterial invasion and proliferation impair host immune responses, leading to localized periodontal tissue inflammation and bone destruction. Conventional periodontal therapies face challenges, including incomplete microbial clearance and the rise of antibiotic resistance, limiting their precision and effectiveness in managing periodontitis. Recently, nanotherapies based on polymeric materials have introduced advanced approaches to periodontal antimicrobial therapy through diverse antimicrobial mechanisms. This review explored specific mechanisms, emphasizing the design of polymer-based agents that employ individual or synergistic antimicrobial actions, and evaluated the innovations and limitations of current strategies while forecasting future trends in antimicrobial development for periodontitis.https://www.frontiersin.org/articles/10.3389/fphar.2024.1533964/fullantimicrobialpolymerperiodontitisnanotherapiesmechanisms |
| spellingShingle | Jiajia Chen Shujun Dong Polymer-based antimicrobial strategies for periodontitis Frontiers in Pharmacology antimicrobial polymer periodontitis nanotherapies mechanisms |
| title | Polymer-based antimicrobial strategies for periodontitis |
| title_full | Polymer-based antimicrobial strategies for periodontitis |
| title_fullStr | Polymer-based antimicrobial strategies for periodontitis |
| title_full_unstemmed | Polymer-based antimicrobial strategies for periodontitis |
| title_short | Polymer-based antimicrobial strategies for periodontitis |
| title_sort | polymer based antimicrobial strategies for periodontitis |
| topic | antimicrobial polymer periodontitis nanotherapies mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1533964/full |
| work_keys_str_mv | AT jiajiachen polymerbasedantimicrobialstrategiesforperiodontitis AT shujundong polymerbasedantimicrobialstrategiesforperiodontitis |