Bioinformatics analysis of mitochondrial metabolism-related genes demonstrates their importance in renal cell carcinoma
Abstract Purpose Clear cell renal cell carcinoma (ccRCC) is resistant to radiotherapy and chemotherapy. Thus, it is necessary to find new diagnostic markers and therapeutic targets to increase the overall outcomes of ccRCC. Recent studies have shown that therapeutic methods that interfere with the e...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01780-4 |
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| author | Mohsen Ahmadi Maryam Motallebinezhad Pegah Mousavi Amir Hossein Miladipour Shamim Fooladgar Soudeh Ghafouri-Fard Seyed Amirhossein Fazeli |
| author_facet | Mohsen Ahmadi Maryam Motallebinezhad Pegah Mousavi Amir Hossein Miladipour Shamim Fooladgar Soudeh Ghafouri-Fard Seyed Amirhossein Fazeli |
| author_sort | Mohsen Ahmadi |
| collection | DOAJ |
| description | Abstract Purpose Clear cell renal cell carcinoma (ccRCC) is resistant to radiotherapy and chemotherapy. Thus, it is necessary to find new diagnostic markers and therapeutic targets to increase the overall outcomes of ccRCC. Recent studies have shown that therapeutic methods that interfere with the energy transfer system can also positively affect the treatment process. Methods The present study is focused on finding markers associated with mitochondrial metabolic pathways that affect the outcome of ccRCC. For this purpose, we investigated various aspects of the relationship between mitochondrial metabolism and ccRCC based on analysis of gene network connections and differentially expressed genes, through assessment of protein–protein interaction, mutations, and promoter methylation on the related genes. We also investigated gene interaction with miRNAs and immune infiltration analysis. Results Through these steps, we provided a list of possible diagnostic markers and therapeutic targets for ccRCC. Conclusion The current study further proved the importance of mitochondrial metabolic pathways in the pathogenesis of ccRCC and provided a list of possible diagnostic markers and therapeutic targets from these pathways that can be used in ccRCC. |
| format | Article |
| id | doaj-art-b0c00cc3d7e242c6b8d2406bf0305fb3 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-b0c00cc3d7e242c6b8d2406bf0305fb32025-01-12T12:29:06ZengSpringerDiscover Oncology2730-60112025-01-0116111910.1007/s12672-025-01780-4Bioinformatics analysis of mitochondrial metabolism-related genes demonstrates their importance in renal cell carcinomaMohsen Ahmadi0Maryam Motallebinezhad1Pegah Mousavi2Amir Hossein Miladipour3Shamim Fooladgar4Soudeh Ghafouri-Fard5Seyed Amirhossein Fazeli6Student Research Committee, School of Medicine, Shahid Beheshti University of Medical SciencesStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical SciencesMolecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical SciencesChronic Kidney Disease Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical SciencesDepartment of Biology, School of Converging Sciences and Technologies, Science and Research Branch, Islamic Azad UniversityDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical SciencesClinical Research and Development Center, Division of Nephrology, Department of Internal Medicine, Shahid Modarres Hospital, Shahid Beheshti University of Medical SciencesAbstract Purpose Clear cell renal cell carcinoma (ccRCC) is resistant to radiotherapy and chemotherapy. Thus, it is necessary to find new diagnostic markers and therapeutic targets to increase the overall outcomes of ccRCC. Recent studies have shown that therapeutic methods that interfere with the energy transfer system can also positively affect the treatment process. Methods The present study is focused on finding markers associated with mitochondrial metabolic pathways that affect the outcome of ccRCC. For this purpose, we investigated various aspects of the relationship between mitochondrial metabolism and ccRCC based on analysis of gene network connections and differentially expressed genes, through assessment of protein–protein interaction, mutations, and promoter methylation on the related genes. We also investigated gene interaction with miRNAs and immune infiltration analysis. Results Through these steps, we provided a list of possible diagnostic markers and therapeutic targets for ccRCC. Conclusion The current study further proved the importance of mitochondrial metabolic pathways in the pathogenesis of ccRCC and provided a list of possible diagnostic markers and therapeutic targets from these pathways that can be used in ccRCC.https://doi.org/10.1007/s12672-025-01780-4Mitochondrial energy metabolismRenal cell carcinoma |
| spellingShingle | Mohsen Ahmadi Maryam Motallebinezhad Pegah Mousavi Amir Hossein Miladipour Shamim Fooladgar Soudeh Ghafouri-Fard Seyed Amirhossein Fazeli Bioinformatics analysis of mitochondrial metabolism-related genes demonstrates their importance in renal cell carcinoma Discover Oncology Mitochondrial energy metabolism Renal cell carcinoma |
| title | Bioinformatics analysis of mitochondrial metabolism-related genes demonstrates their importance in renal cell carcinoma |
| title_full | Bioinformatics analysis of mitochondrial metabolism-related genes demonstrates their importance in renal cell carcinoma |
| title_fullStr | Bioinformatics analysis of mitochondrial metabolism-related genes demonstrates their importance in renal cell carcinoma |
| title_full_unstemmed | Bioinformatics analysis of mitochondrial metabolism-related genes demonstrates their importance in renal cell carcinoma |
| title_short | Bioinformatics analysis of mitochondrial metabolism-related genes demonstrates their importance in renal cell carcinoma |
| title_sort | bioinformatics analysis of mitochondrial metabolism related genes demonstrates their importance in renal cell carcinoma |
| topic | Mitochondrial energy metabolism Renal cell carcinoma |
| url | https://doi.org/10.1007/s12672-025-01780-4 |
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