Diagnostic and mechanistic roles of MicroRNAs in neurodevelopmental & neurodegenerative disorders
MicroRNAs (miRNAs) are emerging as crucial elements in the regulation of gene expression, playing a significant role in the underlying neurobiology of a wide range of neuropsychiatric disorders. This review examines the intricate involvement of miRNAs in neuropsychiatric disorders, such as Alzheimer...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S096999612400319X |
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| author | Mohamed Adil Shah Khoodoruth Widaad Nuzhah Chut-kai Khoodoruth Maira Uroos Majid Al-Abdulla Yasser Saeed Khan Farhan Mohammad |
| author_facet | Mohamed Adil Shah Khoodoruth Widaad Nuzhah Chut-kai Khoodoruth Maira Uroos Majid Al-Abdulla Yasser Saeed Khan Farhan Mohammad |
| author_sort | Mohamed Adil Shah Khoodoruth |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are emerging as crucial elements in the regulation of gene expression, playing a significant role in the underlying neurobiology of a wide range of neuropsychiatric disorders. This review examines the intricate involvement of miRNAs in neuropsychiatric disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Fragile X syndrome (FXS), autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), Tourette syndrome (TS), schizophrenia (SCZ), and mood disorders. This review highlights how miRNA dysregulation can illuminate the molecular pathways of these diseases and potentially serve as biomarkers for early diagnosis and prognosis. Specifically, miRNAs' ability to target genes critical to the pathology of neurodegenerative diseases, their role in the development of trinucleotide repeat and neurodevelopmental disorders, and their distinctive patterns in SCZ and mood disorders are discussed. The review also stresses the value of miRNAs in precision neuropsychiatry, where they could predict treatment outcomes and aid in disease management. Furthermore, the study of conserved miRNAs in model organisms like Drosophila underscores their broad utility and provides deeper mechanistic insights into their biological functions. This comprehensive examination of miRNAs across various conditions advocates for their integration into clinical practice, promising advancements in personalized healthcare for neurological and psychiatric conditions. |
| format | Article |
| id | doaj-art-b0b7ec95ec1f4b6b9b30c4d2ffe2c31c |
| institution | Kabale University |
| issn | 1095-953X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj-art-b0b7ec95ec1f4b6b9b30c4d2ffe2c31c2024-11-20T05:06:32ZengElsevierNeurobiology of Disease1095-953X2024-11-01202106717Diagnostic and mechanistic roles of MicroRNAs in neurodevelopmental & neurodegenerative disordersMohamed Adil Shah Khoodoruth0Widaad Nuzhah Chut-kai Khoodoruth1Maira Uroos2Majid Al-Abdulla3Yasser Saeed Khan4Farhan Mohammad5Child and Adolescent Mental Health Service, Hamad Medical Corporation, Doha, Qatar; College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, QatarCentre of Disease Control and Prevention Department, Hamad Medical Corporation, QatarAmerican School of Doha, QatarMental Health Service, Hamad Medical Corporation, Doha, Qatar; College of Medicine, Qatar University, Doha, QatarChild and Adolescent Mental Health Service, Hamad Medical Corporation, Doha, QatarCollege of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar; Corresponding author.MicroRNAs (miRNAs) are emerging as crucial elements in the regulation of gene expression, playing a significant role in the underlying neurobiology of a wide range of neuropsychiatric disorders. This review examines the intricate involvement of miRNAs in neuropsychiatric disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Fragile X syndrome (FXS), autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), Tourette syndrome (TS), schizophrenia (SCZ), and mood disorders. This review highlights how miRNA dysregulation can illuminate the molecular pathways of these diseases and potentially serve as biomarkers for early diagnosis and prognosis. Specifically, miRNAs' ability to target genes critical to the pathology of neurodegenerative diseases, their role in the development of trinucleotide repeat and neurodevelopmental disorders, and their distinctive patterns in SCZ and mood disorders are discussed. The review also stresses the value of miRNAs in precision neuropsychiatry, where they could predict treatment outcomes and aid in disease management. Furthermore, the study of conserved miRNAs in model organisms like Drosophila underscores their broad utility and provides deeper mechanistic insights into their biological functions. This comprehensive examination of miRNAs across various conditions advocates for their integration into clinical practice, promising advancements in personalized healthcare for neurological and psychiatric conditions.http://www.sciencedirect.com/science/article/pii/S096999612400319XmicroRNAEpigeneticsGene expressionNeuropsychiatryDiagnostics |
| spellingShingle | Mohamed Adil Shah Khoodoruth Widaad Nuzhah Chut-kai Khoodoruth Maira Uroos Majid Al-Abdulla Yasser Saeed Khan Farhan Mohammad Diagnostic and mechanistic roles of MicroRNAs in neurodevelopmental & neurodegenerative disorders Neurobiology of Disease microRNA Epigenetics Gene expression Neuropsychiatry Diagnostics |
| title | Diagnostic and mechanistic roles of MicroRNAs in neurodevelopmental & neurodegenerative disorders |
| title_full | Diagnostic and mechanistic roles of MicroRNAs in neurodevelopmental & neurodegenerative disorders |
| title_fullStr | Diagnostic and mechanistic roles of MicroRNAs in neurodevelopmental & neurodegenerative disorders |
| title_full_unstemmed | Diagnostic and mechanistic roles of MicroRNAs in neurodevelopmental & neurodegenerative disorders |
| title_short | Diagnostic and mechanistic roles of MicroRNAs in neurodevelopmental & neurodegenerative disorders |
| title_sort | diagnostic and mechanistic roles of micrornas in neurodevelopmental amp neurodegenerative disorders |
| topic | microRNA Epigenetics Gene expression Neuropsychiatry Diagnostics |
| url | http://www.sciencedirect.com/science/article/pii/S096999612400319X |
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