Conventional and Emerging Diagnostic Approaches for Differentiated Thyroid Carcinoma
Differentiated thyroid carcinoma (DTC) is among the most prevalent endocrine cancers. The diagnosis of DTC has witnessed tremendous progress in terms of technological advancement and clinical operational guidelines. DTC diagnostics have evolved significantly over centuries, from early clinical exami...
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| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/12/11/229 |
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| author | Kathelina Kristollari Abraham Abbey Paul Sagi Angel Robert S. Marks |
| author_facet | Kathelina Kristollari Abraham Abbey Paul Sagi Angel Robert S. Marks |
| author_sort | Kathelina Kristollari |
| collection | DOAJ |
| description | Differentiated thyroid carcinoma (DTC) is among the most prevalent endocrine cancers. The diagnosis of DTC has witnessed tremendous progress in terms of technological advancement and clinical operational guidelines. DTC diagnostics have evolved significantly over centuries, from early clinical examinations to modern molecular testing and imaging modalities. The diagnosis and management of DTC are currently dependent on the international histological classification and identification of specific genetic abnormalities in tumor tissue, as well as the prognostic implications that can inform treatment decisions. This study goes down the memory lanes of various diagnostic methods for DTCs, highlighting recent advancements in molecular testing and point-of-care (POC) technology. Beginning with conventional methods like fine needle aspiration biopsy (FNAB), fine needle aspiration cytology (FNAC), and ultrasound (US) and moving to contemporary innovative approaches such as POC-thyroglobulin (POC-Tg) and liquid biopsy, this review showcases the current trends in DTC diagnostics. Although considerable progress has been achieved in early malignancy detection, patient stratification, prognosis, and personalized treatment, there is a need to refine the mainstay diagnostic procedures. Finally, future perspectives were provided, and emerging roles of artificial intelligence in DTC diagnostics were explored. |
| format | Article |
| id | doaj-art-b0b7da74b3b049208aaac0b0ce481d1d |
| institution | Kabale University |
| issn | 2227-9040 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj-art-b0b7da74b3b049208aaac0b0ce481d1d2024-11-26T17:57:12ZengMDPI AGChemosensors2227-90402024-11-01121122910.3390/chemosensors12110229Conventional and Emerging Diagnostic Approaches for Differentiated Thyroid CarcinomaKathelina Kristollari0Abraham Abbey Paul1Sagi Angel2Robert S. Marks3Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Be’er Sheva 84105, IsraelAvram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Be’er Sheva 84105, IsraelPicodya Technologies Ltd., Rehovot 7670402, IsraelAvram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Be’er Sheva 84105, IsraelDifferentiated thyroid carcinoma (DTC) is among the most prevalent endocrine cancers. The diagnosis of DTC has witnessed tremendous progress in terms of technological advancement and clinical operational guidelines. DTC diagnostics have evolved significantly over centuries, from early clinical examinations to modern molecular testing and imaging modalities. The diagnosis and management of DTC are currently dependent on the international histological classification and identification of specific genetic abnormalities in tumor tissue, as well as the prognostic implications that can inform treatment decisions. This study goes down the memory lanes of various diagnostic methods for DTCs, highlighting recent advancements in molecular testing and point-of-care (POC) technology. Beginning with conventional methods like fine needle aspiration biopsy (FNAB), fine needle aspiration cytology (FNAC), and ultrasound (US) and moving to contemporary innovative approaches such as POC-thyroglobulin (POC-Tg) and liquid biopsy, this review showcases the current trends in DTC diagnostics. Although considerable progress has been achieved in early malignancy detection, patient stratification, prognosis, and personalized treatment, there is a need to refine the mainstay diagnostic procedures. Finally, future perspectives were provided, and emerging roles of artificial intelligence in DTC diagnostics were explored.https://www.mdpi.com/2227-9040/12/11/229differentiated thyroid carcinomadiagnosticsbiomarkerspoint-of-care testing |
| spellingShingle | Kathelina Kristollari Abraham Abbey Paul Sagi Angel Robert S. Marks Conventional and Emerging Diagnostic Approaches for Differentiated Thyroid Carcinoma Chemosensors differentiated thyroid carcinoma diagnostics biomarkers point-of-care testing |
| title | Conventional and Emerging Diagnostic Approaches for Differentiated Thyroid Carcinoma |
| title_full | Conventional and Emerging Diagnostic Approaches for Differentiated Thyroid Carcinoma |
| title_fullStr | Conventional and Emerging Diagnostic Approaches for Differentiated Thyroid Carcinoma |
| title_full_unstemmed | Conventional and Emerging Diagnostic Approaches for Differentiated Thyroid Carcinoma |
| title_short | Conventional and Emerging Diagnostic Approaches for Differentiated Thyroid Carcinoma |
| title_sort | conventional and emerging diagnostic approaches for differentiated thyroid carcinoma |
| topic | differentiated thyroid carcinoma diagnostics biomarkers point-of-care testing |
| url | https://www.mdpi.com/2227-9040/12/11/229 |
| work_keys_str_mv | AT kathelinakristollari conventionalandemergingdiagnosticapproachesfordifferentiatedthyroidcarcinoma AT abrahamabbeypaul conventionalandemergingdiagnosticapproachesfordifferentiatedthyroidcarcinoma AT sagiangel conventionalandemergingdiagnosticapproachesfordifferentiatedthyroidcarcinoma AT robertsmarks conventionalandemergingdiagnosticapproachesfordifferentiatedthyroidcarcinoma |