Natural history of radiotherapy-induced dysgeusia among oral and oropharyngeal cancer patients undergoing different treatment modalities
Aims: To assess the patterns of radiotherapy-induced dysgeusia among oral and oropharyngeal squamous cell carcinoma (OOSCC) patients subjected to different oncological treatment modalities. Patients and methods: OOSCC patients who underwent head and neck radiotherapy (HNRT) or chemoradiotherapy (CRT...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024000311 |
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| author | Natália Rangel Palmier Bruno Augusto Linhares Almeida Mariz Letícia Rodrigues-Oliveira Karina Morais-Faria César Augusto Migliorati Luiz Paulo Kowalski Karina Moutinho Thaís Bianca Brandão Alan Roger Santos-Silva Ana Carolina Prado-Ribeiro |
| author_facet | Natália Rangel Palmier Bruno Augusto Linhares Almeida Mariz Letícia Rodrigues-Oliveira Karina Morais-Faria César Augusto Migliorati Luiz Paulo Kowalski Karina Moutinho Thaís Bianca Brandão Alan Roger Santos-Silva Ana Carolina Prado-Ribeiro |
| author_sort | Natália Rangel Palmier |
| collection | DOAJ |
| description | Aims: To assess the patterns of radiotherapy-induced dysgeusia among oral and oropharyngeal squamous cell carcinoma (OOSCC) patients subjected to different oncological treatment modalities. Patients and methods: OOSCC patients who underwent head and neck radiotherapy (HNRT) or chemoradiotherapy (CRT). Patients were paired in 8 groups divided by primary treatment (surgery or induction CT) followed by CRT or HNRT and definitive treatment with CRT or HNRT. Dysgeusia, xerostomia, oral mucositis (OM) grades and tube feeding information were retrieved from electronic medical charts. Statistical analysis was performed regarding the correlation of treatment modalities with dysgeusia, and of xerostomia and OM with dysgeusia. Results: 150 patients were included. Over 90 % of patients developed dysgeusia during HNRT. Groups that included CRT presented early severe dysgeusia. Tongue surgery followed by CRT presented grade 2 at 10Gy when compared to HNRT (p = 0.04), groups with other surgery (such as mandibulectomy) or induction CT followed by CRT presented more grade 2 dysgeusia at 40Gy of HNRT (p = 0.04). Xerostomia and dysgeusia grades and OM and dysgeusia grades presented a positive correlation (P < 0.001, each). Malnutrition associated with appetite loss and dysgeusia was the indication for tube feeding in 26.8 % of patients. Conclusions: CRT protocols may be predictors early-onset dysgeusia. A positive correlation of xerostomia and OM with dysgeusia grades may lead to a decrease in appetite and weight loss. High incidence of tube feeding use due to mal-nutrition associated to appetite loss and dysgeusia highlights the importance of working on strategies for dysgeusia management. |
| format | Article |
| id | doaj-art-b0b453f1f51a48088aa55b59b4222fb8 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-b0b453f1f51a48088aa55b59b4222fb82025-01-09T06:15:16ZengElsevierOral Oncology Reports2772-90602024-03-019100185Natural history of radiotherapy-induced dysgeusia among oral and oropharyngeal cancer patients undergoing different treatment modalitiesNatália Rangel Palmier0Bruno Augusto Linhares Almeida Mariz1Letícia Rodrigues-Oliveira2Karina Morais-Faria3César Augusto Migliorati4Luiz Paulo Kowalski5Karina Moutinho6Thaís Bianca Brandão7Alan Roger Santos-Silva8Ana Carolina Prado-Ribeiro9Oral Diagnosis Department, Piracicaba Dental School, UNICAMP, Brazil; Dental Oncology Service, São Paulo State Cancer Institute, ICESP-FMUSP, Brazil; Corresponding author. Dental Oncology Service, Instituto do Câncer do Estado de São Paulo (ICESP), Av. Dr. Arnaldo, 251 - Cerqueira César, São Paulo, SP, 01246-000, Brazil.Oral Diagnosis Department, Piracicaba Dental School, UNICAMP, BrazilOral Diagnosis Department, Piracicaba Dental School, UNICAMP, BrazilDental Oncology Service, São Paulo State Cancer Institute, ICESP-FMUSP, BrazilCollege of Dentistry, University of Florida, Gainesville, FL, USACentral Institute, Hospital das Clínicas of the University of São Paulo Medical School (FMUSP), BrazilService of Radiation Oncology, Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil; Radiotherapy D'Or, São Paulo, BrazilDental Oncology Service, São Paulo State Cancer Institute, ICESP-FMUSP, BrazilOral Diagnosis Department, Piracicaba Dental School, UNICAMP, BrazilDental Oncology Service, São Paulo State Cancer Institute, ICESP-FMUSP, BrazilAims: To assess the patterns of radiotherapy-induced dysgeusia among oral and oropharyngeal squamous cell carcinoma (OOSCC) patients subjected to different oncological treatment modalities. Patients and methods: OOSCC patients who underwent head and neck radiotherapy (HNRT) or chemoradiotherapy (CRT). Patients were paired in 8 groups divided by primary treatment (surgery or induction CT) followed by CRT or HNRT and definitive treatment with CRT or HNRT. Dysgeusia, xerostomia, oral mucositis (OM) grades and tube feeding information were retrieved from electronic medical charts. Statistical analysis was performed regarding the correlation of treatment modalities with dysgeusia, and of xerostomia and OM with dysgeusia. Results: 150 patients were included. Over 90 % of patients developed dysgeusia during HNRT. Groups that included CRT presented early severe dysgeusia. Tongue surgery followed by CRT presented grade 2 at 10Gy when compared to HNRT (p = 0.04), groups with other surgery (such as mandibulectomy) or induction CT followed by CRT presented more grade 2 dysgeusia at 40Gy of HNRT (p = 0.04). Xerostomia and dysgeusia grades and OM and dysgeusia grades presented a positive correlation (P < 0.001, each). Malnutrition associated with appetite loss and dysgeusia was the indication for tube feeding in 26.8 % of patients. Conclusions: CRT protocols may be predictors early-onset dysgeusia. A positive correlation of xerostomia and OM with dysgeusia grades may lead to a decrease in appetite and weight loss. High incidence of tube feeding use due to mal-nutrition associated to appetite loss and dysgeusia highlights the importance of working on strategies for dysgeusia management.http://www.sciencedirect.com/science/article/pii/S2772906024000311Head and neck cancerHead and neck radiotherapyChemotherapyHead and neck surgeryDysgeusiaXerostomia |
| spellingShingle | Natália Rangel Palmier Bruno Augusto Linhares Almeida Mariz Letícia Rodrigues-Oliveira Karina Morais-Faria César Augusto Migliorati Luiz Paulo Kowalski Karina Moutinho Thaís Bianca Brandão Alan Roger Santos-Silva Ana Carolina Prado-Ribeiro Natural history of radiotherapy-induced dysgeusia among oral and oropharyngeal cancer patients undergoing different treatment modalities Oral Oncology Reports Head and neck cancer Head and neck radiotherapy Chemotherapy Head and neck surgery Dysgeusia Xerostomia |
| title | Natural history of radiotherapy-induced dysgeusia among oral and oropharyngeal cancer patients undergoing different treatment modalities |
| title_full | Natural history of radiotherapy-induced dysgeusia among oral and oropharyngeal cancer patients undergoing different treatment modalities |
| title_fullStr | Natural history of radiotherapy-induced dysgeusia among oral and oropharyngeal cancer patients undergoing different treatment modalities |
| title_full_unstemmed | Natural history of radiotherapy-induced dysgeusia among oral and oropharyngeal cancer patients undergoing different treatment modalities |
| title_short | Natural history of radiotherapy-induced dysgeusia among oral and oropharyngeal cancer patients undergoing different treatment modalities |
| title_sort | natural history of radiotherapy induced dysgeusia among oral and oropharyngeal cancer patients undergoing different treatment modalities |
| topic | Head and neck cancer Head and neck radiotherapy Chemotherapy Head and neck surgery Dysgeusia Xerostomia |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024000311 |
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