Natural history of radiotherapy-induced dysgeusia among oral and oropharyngeal cancer patients undergoing different treatment modalities

Natural history of radiotherapy-induced dysgeusia among oral and oropharyngeal cancer patients undergoing different treatment modalities

Aims: To assess the patterns of radiotherapy-induced dysgeusia among oral and oropharyngeal squamous cell carcinoma (OOSCC) patients subjected to different oncological treatment modalities. Patients and methods: OOSCC patients who underwent head and neck radiotherapy (HNRT) or chemoradiotherapy (CRT...

Full description

Saved in:
Bibliographic Details
Main Authors: Natália Rangel Palmier, Bruno Augusto Linhares Almeida Mariz, Letícia Rodrigues-Oliveira, Karina Morais-Faria, César Augusto Migliorati, Luiz Paulo Kowalski, Karina Moutinho, Thaís Bianca Brandão, Alan Roger Santos-Silva, Ana Carolina Prado-Ribeiro
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Oral Oncology Reports
Subjects:
Head and neck cancer
Head and neck radiotherapy
Chemotherapy
Head and neck surgery
Dysgeusia
Xerostomia
Online Access:http://www.sciencedirect.com/science/article/pii/S2772906024000311
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims: To assess the patterns of radiotherapy-induced dysgeusia among oral and oropharyngeal squamous cell carcinoma (OOSCC) patients subjected to different oncological treatment modalities. Patients and methods: OOSCC patients who underwent head and neck radiotherapy (HNRT) or chemoradiotherapy (CRT). Patients were paired in 8 groups divided by primary treatment (surgery or induction CT) followed by CRT or HNRT and definitive treatment with CRT or HNRT. Dysgeusia, xerostomia, oral mucositis (OM) grades and tube feeding information were retrieved from electronic medical charts. Statistical analysis was performed regarding the correlation of treatment modalities with dysgeusia, and of xerostomia and OM with dysgeusia. Results: 150 patients were included. Over 90 % of patients developed dysgeusia during HNRT. Groups that included CRT presented early severe dysgeusia. Tongue surgery followed by CRT presented grade 2 at 10Gy when compared to HNRT (p = 0.04), groups with other surgery (such as mandibulectomy) or induction CT followed by CRT presented more grade 2 dysgeusia at 40Gy of HNRT (p = 0.04). Xerostomia and dysgeusia grades and OM and dysgeusia grades presented a positive correlation (P < 0.001, each). Malnutrition associated with appetite loss and dysgeusia was the indication for tube feeding in 26.8 % of patients. Conclusions: CRT protocols may be predictors early-onset dysgeusia. A positive correlation of xerostomia and OM with dysgeusia grades may lead to a decrease in appetite and weight loss. High incidence of tube feeding use due to mal-nutrition associated to appetite loss and dysgeusia highlights the importance of working on strategies for dysgeusia management.
ISSN:2772-9060

Similar Items