Association between the fibrosis-4 and the risk of left ventricular aneurysm formation in acute ST-segment elevation myocardial infarction
BackgroundLeft ventricular aneurysm (LVA) often occurs as a complication following an acute myocardial infarction. This research focused on assessing the ability of the fibrosis-4 (FIB-4) index to predict LVA formation in individuals with acute ST-segment elevation myocardial infarction (STEMI) who...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1477206/full |
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| author | Kai Zhang Lihong Yang Yonghui Zhao |
| author_facet | Kai Zhang Lihong Yang Yonghui Zhao |
| author_sort | Kai Zhang |
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| description | BackgroundLeft ventricular aneurysm (LVA) often occurs as a complication following an acute myocardial infarction. This research focused on assessing the ability of the fibrosis-4 (FIB-4) index to predict LVA formation in individuals with acute ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI).MethodsWe included 1,384 consecutive patients diagnosed with STEMI and compared their clinical and laboratory data between the LVA group and the non-LVA group. To determine the independent risk factors for LVA formation, multivariable logistic regression analysis was employed. Restricted cubic spline (RCS) analysis was conducted to evaluate the nonlinear relationship between FIB-4 index and LVA formation. The ROC curve was used to determine the predictive capability of the FIB-4 index and composite variable for LVA formation.ResultsLVA occurred in 12.7% of the population. An elevated FIB-4 index correlated with a higher occurrence of LVA (19% vs. 9.3%, P < 0.001). In the LVA group, the FIB-4 index was higher than in the non-LVA group [1.8 (1.1–4.6) vs. 3.5 (1.4–8.1), P < 0.001]. Analysis using multivariable logistic regression showed that the FIB-4 index independently correlated with LVA risk (OR = 1.73, P = 0.004). The analysis using RCS uncovered a nonlinear correlation between a higher FIB-4 index and a heightened risk of LVA (Nonlinear P = 0.009). Additionally, the area under the ROC curve for the FIB-4 index in predicting LVA was 0.617. The composite variable comprising the FIB-4 index, left ventricular ejection fraction (LVEF), estimated glomerular filtration rate (eGFR), and left anterior descending artery (LAD) as culprit vessel significantly improved the predictive power (C statistic = 0.722).ConclusionAn increased FIB-4 index was positively associated with LVA formation in patients with acute STEMI who underwent primary PCI. |
| format | Article |
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| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-b0a4a13aa02e49fda3db0946a3c60c6c2025-08-20T03:46:33ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-06-011210.3389/fcvm.2025.14772061477206Association between the fibrosis-4 and the risk of left ventricular aneurysm formation in acute ST-segment elevation myocardial infarctionKai Zhang0Lihong Yang1Yonghui Zhao2People's Hospital of Zhengzhou University, Fuwai Central China Cardiovascular Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, ChinaHenan Provincial People's Hospital, Zhengzhou, Henan, ChinaPeople's Hospital of Zhengzhou University, Fuwai Central China Cardiovascular Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, ChinaBackgroundLeft ventricular aneurysm (LVA) often occurs as a complication following an acute myocardial infarction. This research focused on assessing the ability of the fibrosis-4 (FIB-4) index to predict LVA formation in individuals with acute ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI).MethodsWe included 1,384 consecutive patients diagnosed with STEMI and compared their clinical and laboratory data between the LVA group and the non-LVA group. To determine the independent risk factors for LVA formation, multivariable logistic regression analysis was employed. Restricted cubic spline (RCS) analysis was conducted to evaluate the nonlinear relationship between FIB-4 index and LVA formation. The ROC curve was used to determine the predictive capability of the FIB-4 index and composite variable for LVA formation.ResultsLVA occurred in 12.7% of the population. An elevated FIB-4 index correlated with a higher occurrence of LVA (19% vs. 9.3%, P < 0.001). In the LVA group, the FIB-4 index was higher than in the non-LVA group [1.8 (1.1–4.6) vs. 3.5 (1.4–8.1), P < 0.001]. Analysis using multivariable logistic regression showed that the FIB-4 index independently correlated with LVA risk (OR = 1.73, P = 0.004). The analysis using RCS uncovered a nonlinear correlation between a higher FIB-4 index and a heightened risk of LVA (Nonlinear P = 0.009). Additionally, the area under the ROC curve for the FIB-4 index in predicting LVA was 0.617. The composite variable comprising the FIB-4 index, left ventricular ejection fraction (LVEF), estimated glomerular filtration rate (eGFR), and left anterior descending artery (LAD) as culprit vessel significantly improved the predictive power (C statistic = 0.722).ConclusionAn increased FIB-4 index was positively associated with LVA formation in patients with acute STEMI who underwent primary PCI.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1477206/fullacute ST-segment elevation myocardial infarctionprimary percutaneous coronary interventionleft ventricular aneurysmfibrosis-4 indexrisk |
| spellingShingle | Kai Zhang Lihong Yang Yonghui Zhao Association between the fibrosis-4 and the risk of left ventricular aneurysm formation in acute ST-segment elevation myocardial infarction Frontiers in Cardiovascular Medicine acute ST-segment elevation myocardial infarction primary percutaneous coronary intervention left ventricular aneurysm fibrosis-4 index risk |
| title | Association between the fibrosis-4 and the risk of left ventricular aneurysm formation in acute ST-segment elevation myocardial infarction |
| title_full | Association between the fibrosis-4 and the risk of left ventricular aneurysm formation in acute ST-segment elevation myocardial infarction |
| title_fullStr | Association between the fibrosis-4 and the risk of left ventricular aneurysm formation in acute ST-segment elevation myocardial infarction |
| title_full_unstemmed | Association between the fibrosis-4 and the risk of left ventricular aneurysm formation in acute ST-segment elevation myocardial infarction |
| title_short | Association between the fibrosis-4 and the risk of left ventricular aneurysm formation in acute ST-segment elevation myocardial infarction |
| title_sort | association between the fibrosis 4 and the risk of left ventricular aneurysm formation in acute st segment elevation myocardial infarction |
| topic | acute ST-segment elevation myocardial infarction primary percutaneous coronary intervention left ventricular aneurysm fibrosis-4 index risk |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1477206/full |
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