Lipid droplet biogenesis in the ovary
Abstract Background Lipid droplets (LDs) are organelles consisting of a central core of neutral lipids covered by a single layer of phospholipids and are found in most eukaryotic cells. Accumulating evidence suggests that LDs not only store neutral lipids but also coordinate with other organelles fo...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Reproductive Medicine and Biology |
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| Online Access: | https://doi.org/10.1002/rmb2.12618 |
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| author | Megumi Ibayashi Satoshi Tsukamoto |
| author_facet | Megumi Ibayashi Satoshi Tsukamoto |
| author_sort | Megumi Ibayashi |
| collection | DOAJ |
| description | Abstract Background Lipid droplets (LDs) are organelles consisting of a central core of neutral lipids covered by a single layer of phospholipids and are found in most eukaryotic cells. Accumulating evidence suggests that LDs not only store neutral lipids but also coordinate with other organelles for lipid metabolism within cells. Methods This review focuses on the synthesis of LDs during follicular development and highlights the factors involved in the regulation of LD biogenesis within the ovary. Main Findings In the mammalian ovary, the presence of LDs has long been recognized mainly by morphological analysis. However, their distribution in the ovary varies according to the region and cell type; for example, LDs are abundant in the medulla, which has a rich blood vessel network, in interstitial cells, which are the site of steroid production, and surrounding growing follicles, while they are poor in granulosa cells within follicles. LDs are also enriched in the corpus luteum after ovulation and massively accumulate in atretic follicles during follicular growth. Furthermore, LD synthesis is synchronized with angiogenesis during follicular development. Conclusion Addressing the functional link between LD biogenesis and angiogenesis is essential for understanding the molecular basis underlying LD biology, as well as the ovarian dysfunction with metabolic disorders. |
| format | Article |
| id | doaj-art-b098d32716b14cca9ee6a03148b38df9 |
| institution | Kabale University |
| issn | 1445-5781 1447-0578 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj-art-b098d32716b14cca9ee6a03148b38df92024-12-20T06:08:37ZengWileyReproductive Medicine and Biology1445-57811447-05782024-01-01231n/an/a10.1002/rmb2.12618Lipid droplet biogenesis in the ovaryMegumi Ibayashi0Satoshi Tsukamoto1Laboratory Animal and Bioresource Sciences Section National Institutes for Quantum Science and Technology Chiba JapanLaboratory Animal and Bioresource Sciences Section National Institutes for Quantum Science and Technology Chiba JapanAbstract Background Lipid droplets (LDs) are organelles consisting of a central core of neutral lipids covered by a single layer of phospholipids and are found in most eukaryotic cells. Accumulating evidence suggests that LDs not only store neutral lipids but also coordinate with other organelles for lipid metabolism within cells. Methods This review focuses on the synthesis of LDs during follicular development and highlights the factors involved in the regulation of LD biogenesis within the ovary. Main Findings In the mammalian ovary, the presence of LDs has long been recognized mainly by morphological analysis. However, their distribution in the ovary varies according to the region and cell type; for example, LDs are abundant in the medulla, which has a rich blood vessel network, in interstitial cells, which are the site of steroid production, and surrounding growing follicles, while they are poor in granulosa cells within follicles. LDs are also enriched in the corpus luteum after ovulation and massively accumulate in atretic follicles during follicular growth. Furthermore, LD synthesis is synchronized with angiogenesis during follicular development. Conclusion Addressing the functional link between LD biogenesis and angiogenesis is essential for understanding the molecular basis underlying LD biology, as well as the ovarian dysfunction with metabolic disorders.https://doi.org/10.1002/rmb2.12618angiogenesisfolliclelipid dropletmouseovary |
| spellingShingle | Megumi Ibayashi Satoshi Tsukamoto Lipid droplet biogenesis in the ovary Reproductive Medicine and Biology angiogenesis follicle lipid droplet mouse ovary |
| title | Lipid droplet biogenesis in the ovary |
| title_full | Lipid droplet biogenesis in the ovary |
| title_fullStr | Lipid droplet biogenesis in the ovary |
| title_full_unstemmed | Lipid droplet biogenesis in the ovary |
| title_short | Lipid droplet biogenesis in the ovary |
| title_sort | lipid droplet biogenesis in the ovary |
| topic | angiogenesis follicle lipid droplet mouse ovary |
| url | https://doi.org/10.1002/rmb2.12618 |
| work_keys_str_mv | AT megumiibayashi lipiddropletbiogenesisintheovary AT satoshitsukamoto lipiddropletbiogenesisintheovary |