Using network toxicology and molecular docking to identify core targets and pathways underlying tacrolimus-induced tremor in organ transplant recipients

Using network toxicology and molecular docking to identify core targets and pathways underlying tacrolimus-induced tremor in organ transplant recipients

Abstract Tacrolimus, the most commonly prescribed immunosuppressant following organ transplantation, is associated with various neurotoxic effects, notably tremor, which significantly impacts the quality of life of recipients. The precise mechanisms underlying tacrolimus-induced tremor remain unclea...

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Bibliographic Details
Main Authors: Chao Liu, Qian Chen, Fu Yan, Yulin Niu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Network toxicology
Molecular Docking
Tacrolimus
Tremor
Organ transplantation
Online Access:https://doi.org/10.1038/s41598-025-02381-5
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