The dynamic triage interplay of Hsp90 with its chaperone cycle and client binding

The dynamic triage interplay of Hsp90 with its chaperone cycle and client binding

Abstract Hsp90, a crucial molecular chaperone, regulates diverse client proteins, impacting both normal biology and disease. Central to its function is its conformational plasticity, driven by ATPase activity and client interactions. However, comprehensive insights into Hsp90’s dynamic molecular tra...

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Bibliographic Details
Main Authors: Xiaozhan Qu, Simin Wang, Shuo Zhao, Chanjuan Wan, Weiya Xu, Chengdong Huang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55026-y
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