Idarubicin-loaded drug-eluting microspheres transarterial chemoembolization for intermediate stage hepatocellular carcinoma: safety, efficacy, and pharmacokinetics
Transarterial chemoembolization (TACE) is the treatment of choice for the intermediate stage hepatocellular carcinoma (HCC). Doxorubicin remains the most used chemotherapeutic agent in TACE, although in vitro screening has demonstrated that idarubicin exhibits greater cytotoxicity against HCC. This...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-10-01
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| Series: | Radiology and Oncology |
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| Online Access: | https://doi.org/10.2478/raon-2024-0052 |
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| author | Korsic Spela Osredkar Josko Smid Alojz Steblovnik Klemen Popovic Mark Locatelli Igor Trontelj Jurij Popovic Peter |
| author_facet | Korsic Spela Osredkar Josko Smid Alojz Steblovnik Klemen Popovic Mark Locatelli Igor Trontelj Jurij Popovic Peter |
| author_sort | Korsic Spela |
| collection | DOAJ |
| description | Transarterial chemoembolization (TACE) is the treatment of choice for the intermediate stage hepatocellular carcinoma (HCC). Doxorubicin remains the most used chemotherapeutic agent in TACE, although in vitro screening has demonstrated that idarubicin exhibits greater cytotoxicity against HCC. This study aimed to evaluate safety, efficacy, and pharmacokinetics of idarubicin-loaded drug-eluting microspheres TACE (DEMIDA-TACE) in intermediate stage HCC patients. |
| format | Article |
| id | doaj-art-b057c4fc8cf84aeb9fc7afaa7cd104e2 |
| institution | Kabale University |
| issn | 1581-3207 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj-art-b057c4fc8cf84aeb9fc7afaa7cd104e22025-01-07T07:56:43ZengSciendoRadiology and Oncology1581-32072024-10-0158451752610.2478/raon-2024-0052Idarubicin-loaded drug-eluting microspheres transarterial chemoembolization for intermediate stage hepatocellular carcinoma: safety, efficacy, and pharmacokineticsKorsic Spela0Osredkar Josko1Smid Alojz2Steblovnik Klemen3Popovic Mark4Locatelli Igor5Trontelj Jurij6Popovic Peter7Clinical Institute of Radiology, University Medical Centre Ljubljana, Ljubljana, SloveniaInstitute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, SloveniaBiotechnical Faculty, University of Ljubljana, Ljubljana, SloveniaFaculty of Pharmacy, University of Ljubljana, Ljubljana, SloveniaFaculty of Pharmacy, University of Ljubljana, Ljubljana, SloveniaClinical Institute of Radiology, University Medical Centre Ljubljana, Ljubljana, SloveniaTransarterial chemoembolization (TACE) is the treatment of choice for the intermediate stage hepatocellular carcinoma (HCC). Doxorubicin remains the most used chemotherapeutic agent in TACE, although in vitro screening has demonstrated that idarubicin exhibits greater cytotoxicity against HCC. This study aimed to evaluate safety, efficacy, and pharmacokinetics of idarubicin-loaded drug-eluting microspheres TACE (DEMIDA-TACE) in intermediate stage HCC patients.https://doi.org/10.2478/raon-2024-0052hepatocellular carcinomadrug-eluting microspheres transarterial chemoembolizationidarubicinsafetyefficacypharmacokinetics |
| spellingShingle | Korsic Spela Osredkar Josko Smid Alojz Steblovnik Klemen Popovic Mark Locatelli Igor Trontelj Jurij Popovic Peter Idarubicin-loaded drug-eluting microspheres transarterial chemoembolization for intermediate stage hepatocellular carcinoma: safety, efficacy, and pharmacokinetics Radiology and Oncology hepatocellular carcinoma drug-eluting microspheres transarterial chemoembolization idarubicin safety efficacy pharmacokinetics |
| title | Idarubicin-loaded drug-eluting microspheres transarterial chemoembolization for intermediate stage hepatocellular carcinoma: safety, efficacy, and pharmacokinetics |
| title_full | Idarubicin-loaded drug-eluting microspheres transarterial chemoembolization for intermediate stage hepatocellular carcinoma: safety, efficacy, and pharmacokinetics |
| title_fullStr | Idarubicin-loaded drug-eluting microspheres transarterial chemoembolization for intermediate stage hepatocellular carcinoma: safety, efficacy, and pharmacokinetics |
| title_full_unstemmed | Idarubicin-loaded drug-eluting microspheres transarterial chemoembolization for intermediate stage hepatocellular carcinoma: safety, efficacy, and pharmacokinetics |
| title_short | Idarubicin-loaded drug-eluting microspheres transarterial chemoembolization for intermediate stage hepatocellular carcinoma: safety, efficacy, and pharmacokinetics |
| title_sort | idarubicin loaded drug eluting microspheres transarterial chemoembolization for intermediate stage hepatocellular carcinoma safety efficacy and pharmacokinetics |
| topic | hepatocellular carcinoma drug-eluting microspheres transarterial chemoembolization idarubicin safety efficacy pharmacokinetics |
| url | https://doi.org/10.2478/raon-2024-0052 |
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