Effect of emodin on acute lung injury: a meta-analysis of preclinical trials
Abstract Background Emodin has protective effects on acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). This meta-analysis intended to illustrate the efficacy of emodin on ALI/ARDS animal models. Methods Relevant preclinical studies were searched on PubMed, EMBASE, and Web of Sci...
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BMC
2024-12-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-024-03406-x |
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| author | Lei Liu Yu Zhang Xiao-Ren Tang Guo-Bing Jia Shan Zhou Guo-Long Yue Cheng-Shi He |
| author_facet | Lei Liu Yu Zhang Xiao-Ren Tang Guo-Bing Jia Shan Zhou Guo-Long Yue Cheng-Shi He |
| author_sort | Lei Liu |
| collection | DOAJ |
| description | Abstract Background Emodin has protective effects on acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). This meta-analysis intended to illustrate the efficacy of emodin on ALI/ARDS animal models. Methods Relevant preclinical studies were searched on PubMed, EMBASE, and Web of Science. Standardized mean differences (SMDs) with corresponding confidence intervals (CIs) were used to compare lung injury scores, lung wet-to-dry weight ratios (W/D), myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-18, PaO2, and PaCO2 between the treatment and control groups. The article quality was appraised using the SYRCLE tool. Results Twenty one studies published between 2014 and 2023 were enrolled. Compared with the control group, emodin significantly reduced lung injury scores (SMD: -3.63; 95% CI: -4.36, -2.90; p < 0.00001), W/D ratios (SMD: -3.23; 95% CI: -4.29, -2.16; p < 0.00001), and MPO levels (SMD: -2.96; 95% CI: -3.92, -1.99; p < 0.00001). Furthermore, emodin downregulated TNF-α (SMD: -3.04; 95% CI: -3.62, -2.47; p < 0.00001), IL-1β (SMD: -3.76; 95% CI: -4.65, -2.87; p < 0.00001), IL-6 (SMD: -3.19; 95% CI: -3.95, -2.43; p < 0.00001), and IL-18 levels (SMD: -4.83; 95% CI: -6.10, -3.57; p < 0.00001). Emodin improved gas exchange dysfunction, increased PaO2 (SMD: 3.76; 95% CI: 2.41, 5.11; p < 0.00001), and decreased PaCO2 (SMD: -3.83; 95% CI: -4.90, -2.76; p < 0.00001). Sensitivity analyses and stratified analyses were conducted for outcome measures with heterogeneity. Conclusions Emodin treatment can effectively reduce the severity of ALI in animal models. Additional animal investigations and clinical trials involving human subjects are imperative. |
| format | Article |
| id | doaj-art-b03eced3fd8b407d8f4dc725399ca8d6 |
| institution | Kabale University |
| issn | 1471-2466 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| series | BMC Pulmonary Medicine |
| spelling | doaj-art-b03eced3fd8b407d8f4dc725399ca8d62024-12-08T12:17:21ZengBMCBMC Pulmonary Medicine1471-24662024-12-0124111210.1186/s12890-024-03406-xEffect of emodin on acute lung injury: a meta-analysis of preclinical trialsLei Liu0Yu Zhang1Xiao-Ren Tang2Guo-Bing Jia3Shan Zhou4Guo-Long Yue5Cheng-Shi He6Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese MedicineDepartment of Respiratory Medicine, Traditional Chinese Medicine Hospital of Renshou CountyDepartment of Traditional Chinese Medicine, Bishan Hospital of Chongqing, Bishan Hospital of Chongqing Medical UniversityDepartment of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese MedicineDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese MedicineDepartment of Respiratory and Critical Care Medicine, Chongqing Hospital of Traditional Chinese MedicineDepartment of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese MedicineAbstract Background Emodin has protective effects on acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). This meta-analysis intended to illustrate the efficacy of emodin on ALI/ARDS animal models. Methods Relevant preclinical studies were searched on PubMed, EMBASE, and Web of Science. Standardized mean differences (SMDs) with corresponding confidence intervals (CIs) were used to compare lung injury scores, lung wet-to-dry weight ratios (W/D), myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-18, PaO2, and PaCO2 between the treatment and control groups. The article quality was appraised using the SYRCLE tool. Results Twenty one studies published between 2014 and 2023 were enrolled. Compared with the control group, emodin significantly reduced lung injury scores (SMD: -3.63; 95% CI: -4.36, -2.90; p < 0.00001), W/D ratios (SMD: -3.23; 95% CI: -4.29, -2.16; p < 0.00001), and MPO levels (SMD: -2.96; 95% CI: -3.92, -1.99; p < 0.00001). Furthermore, emodin downregulated TNF-α (SMD: -3.04; 95% CI: -3.62, -2.47; p < 0.00001), IL-1β (SMD: -3.76; 95% CI: -4.65, -2.87; p < 0.00001), IL-6 (SMD: -3.19; 95% CI: -3.95, -2.43; p < 0.00001), and IL-18 levels (SMD: -4.83; 95% CI: -6.10, -3.57; p < 0.00001). Emodin improved gas exchange dysfunction, increased PaO2 (SMD: 3.76; 95% CI: 2.41, 5.11; p < 0.00001), and decreased PaCO2 (SMD: -3.83; 95% CI: -4.90, -2.76; p < 0.00001). Sensitivity analyses and stratified analyses were conducted for outcome measures with heterogeneity. Conclusions Emodin treatment can effectively reduce the severity of ALI in animal models. Additional animal investigations and clinical trials involving human subjects are imperative.https://doi.org/10.1186/s12890-024-03406-xEmodinAcute lung injuryAcute respiratory distress syndromeAnimal modelMeta-analysis |
| spellingShingle | Lei Liu Yu Zhang Xiao-Ren Tang Guo-Bing Jia Shan Zhou Guo-Long Yue Cheng-Shi He Effect of emodin on acute lung injury: a meta-analysis of preclinical trials BMC Pulmonary Medicine Emodin Acute lung injury Acute respiratory distress syndrome Animal model Meta-analysis |
| title | Effect of emodin on acute lung injury: a meta-analysis of preclinical trials |
| title_full | Effect of emodin on acute lung injury: a meta-analysis of preclinical trials |
| title_fullStr | Effect of emodin on acute lung injury: a meta-analysis of preclinical trials |
| title_full_unstemmed | Effect of emodin on acute lung injury: a meta-analysis of preclinical trials |
| title_short | Effect of emodin on acute lung injury: a meta-analysis of preclinical trials |
| title_sort | effect of emodin on acute lung injury a meta analysis of preclinical trials |
| topic | Emodin Acute lung injury Acute respiratory distress syndrome Animal model Meta-analysis |
| url | https://doi.org/10.1186/s12890-024-03406-x |
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