Frequency of IL-1B Gene Polymorphisms in Patients with Gastroesophageal Cancer in the Hakkari Region
Objective: Gastric cancer is a complex malignant tumor associated with chronic inflammation. In the present study, we aimed to investigate the frequency of interleukin 1B (IL-1B) gene polymorphisms affecting gene expression in patients with gastroesophageal cancer (GC) diagnosed in the Hakkari regio...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2024-01-01
|
| Series: | Gazi Medical Journal |
| Subjects: | |
| Online Access: | https://gazimedj.com/articles/frequency-of-lessigreateril-1blessigreater-gene-polymorphisms-in-patients-with-gastroesophageal-cancer-in-the-hakkari-region/doi/gmj.galenos.2022.3646 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841525482122641408 |
|---|---|
| author | Derya Yaman Selin Akad-Dinçer Yusuf Karakaş Gözde Ünsoy Yunus Kasım Terzi Feride İffet Şahin |
| author_facet | Derya Yaman Selin Akad-Dinçer Yusuf Karakaş Gözde Ünsoy Yunus Kasım Terzi Feride İffet Şahin |
| author_sort | Derya Yaman |
| collection | DOAJ |
| description | Objective: Gastric cancer is a complex malignant tumor associated with chronic inflammation. In the present study, we aimed to investigate the frequency of interleukin 1B (IL-1B) gene polymorphisms affecting gene expression in patients with gastroesophageal cancer (GC) diagnosed in the Hakkari region.
Methods: Blood samples of 17 patients with GC (group 1) and 59 healthy controls (group 2) were enrolled in the study. The single-nucleotide polymorphisms (SNPs) rs1143627 c.-118C>T, rs16944 c.-598C>T, and rs1143634 c.315C>T polymorphisms in the IL-1B gene were studied among groups via polymerase chain reaction and restriction fragment length polymorphism. Results were analyzed by descriptive statistics and the x2 test. The association between SNPs and GC risk was evaluated by odd ratios (ORs) and 95% confidence intervals.
Results: The frequencies of the three genotypes in the SNP rs1143627, rs16944, and rs1143634 were similar between the groups, and C>T transition was not found to be significant [(p=0.69, OR: 1.16 95%, confidence interval (CI): 0.54-2.51; p= 0.16, OR: 0.58 95%, CI: 0.26- 1.25; p=0.7, OR: 0.83 95%, CI: 0.32-2.11, respectively].
Conclusion: Our results did not reveal any significant association between IL-1B gene SNPs and gastroesophageal cancer in the Hakkari region. |
| format | Article |
| id | doaj-art-b0271ff74bb645a0801cd353e4c6ac03 |
| institution | Kabale University |
| issn | 2147-2092 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Gazi Medical Journal |
| spelling | doaj-art-b0271ff74bb645a0801cd353e4c6ac032025-01-17T11:10:33ZengGalenos Publishing HouseGazi Medical Journal2147-20922024-01-01351242910.12996/gmj.galenos.2022.3646Frequency of IL-1B Gene Polymorphisms in Patients with Gastroesophageal Cancer in the Hakkari RegionDerya Yaman0https://orcid.org/0000-0002-6425-9105Selin Akad-Dinçer1https://orcid.org/0000-0002-3808-7004Yusuf Karakaş2https://orcid.org/0000-0003-0205-4590Gözde Ünsoy3https://orcid.org/0000-0003-4617-0331Yunus Kasım Terzi4https://orcid.org/0000-0001-5612-9696Feride İffet Şahin5https://orcid.org/0000-0001-7308-9673Başkent University Faculty of Medicine, Department of Medical Genetics, Ankara, TürkiyeBaşkent University Faculty of Medicine, Department of Medical Genetics, Ankara, TürkiyeHakkari State Hospital, Clinic of Oncology, Hakkari, TürkiyeBaşkent University Faculty of Medicine, Department of Medical Genetics, Ankara, TürkiyeBaşkent University Faculty of Medicine, Department of Medical Genetics, Ankara, TürkiyeBaşkent University Faculty of Medicine, Department of Medical Genetics, Ankara, TürkiyeObjective: Gastric cancer is a complex malignant tumor associated with chronic inflammation. In the present study, we aimed to investigate the frequency of interleukin 1B (IL-1B) gene polymorphisms affecting gene expression in patients with gastroesophageal cancer (GC) diagnosed in the Hakkari region. Methods: Blood samples of 17 patients with GC (group 1) and 59 healthy controls (group 2) were enrolled in the study. The single-nucleotide polymorphisms (SNPs) rs1143627 c.-118C>T, rs16944 c.-598C>T, and rs1143634 c.315C>T polymorphisms in the IL-1B gene were studied among groups via polymerase chain reaction and restriction fragment length polymorphism. Results were analyzed by descriptive statistics and the x2 test. The association between SNPs and GC risk was evaluated by odd ratios (ORs) and 95% confidence intervals. Results: The frequencies of the three genotypes in the SNP rs1143627, rs16944, and rs1143634 were similar between the groups, and C>T transition was not found to be significant [(p=0.69, OR: 1.16 95%, confidence interval (CI): 0.54-2.51; p= 0.16, OR: 0.58 95%, CI: 0.26- 1.25; p=0.7, OR: 0.83 95%, CI: 0.32-2.11, respectively]. Conclusion: Our results did not reveal any significant association between IL-1B gene SNPs and gastroesophageal cancer in the Hakkari region.https://gazimedj.com/articles/frequency-of-lessigreateril-1blessigreater-gene-polymorphisms-in-patients-with-gastroesophageal-cancer-in-the-hakkari-region/doi/gmj.galenos.2022.3646gastro-esophageal canceril-1b generestriction fragment length polymorphismrs1143627rs16944rs1143634 |
| spellingShingle | Derya Yaman Selin Akad-Dinçer Yusuf Karakaş Gözde Ünsoy Yunus Kasım Terzi Feride İffet Şahin Frequency of IL-1B Gene Polymorphisms in Patients with Gastroesophageal Cancer in the Hakkari Region Gazi Medical Journal gastro-esophageal cancer il-1b gene restriction fragment length polymorphism rs1143627 rs16944 rs1143634 |
| title | Frequency of IL-1B Gene Polymorphisms in Patients with Gastroesophageal Cancer in the Hakkari Region |
| title_full | Frequency of IL-1B Gene Polymorphisms in Patients with Gastroesophageal Cancer in the Hakkari Region |
| title_fullStr | Frequency of IL-1B Gene Polymorphisms in Patients with Gastroesophageal Cancer in the Hakkari Region |
| title_full_unstemmed | Frequency of IL-1B Gene Polymorphisms in Patients with Gastroesophageal Cancer in the Hakkari Region |
| title_short | Frequency of IL-1B Gene Polymorphisms in Patients with Gastroesophageal Cancer in the Hakkari Region |
| title_sort | frequency of il 1b gene polymorphisms in patients with gastroesophageal cancer in the hakkari region |
| topic | gastro-esophageal cancer il-1b gene restriction fragment length polymorphism rs1143627 rs16944 rs1143634 |
| url | https://gazimedj.com/articles/frequency-of-lessigreateril-1blessigreater-gene-polymorphisms-in-patients-with-gastroesophageal-cancer-in-the-hakkari-region/doi/gmj.galenos.2022.3646 |
| work_keys_str_mv | AT deryayaman frequencyofil1bgenepolymorphismsinpatientswithgastroesophagealcancerinthehakkariregion AT selinakaddincer frequencyofil1bgenepolymorphismsinpatientswithgastroesophagealcancerinthehakkariregion AT yusufkarakas frequencyofil1bgenepolymorphismsinpatientswithgastroesophagealcancerinthehakkariregion AT gozdeunsoy frequencyofil1bgenepolymorphismsinpatientswithgastroesophagealcancerinthehakkariregion AT yunuskasımterzi frequencyofil1bgenepolymorphismsinpatientswithgastroesophagealcancerinthehakkariregion AT ferideiffetsahin frequencyofil1bgenepolymorphismsinpatientswithgastroesophagealcancerinthehakkariregion |