Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance
A variety of receptors perform the function of attenuating or inhibiting activation of cells in which they are expressed. Examples of these kinds of receptors include TIM-3 and PD-1, among others that have been widely studied in cells of lymphoid origin and, though to a lesser degree, in other cell...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/8695157 |
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| author | Ranferi Ocaña-Guzman Luis Vázquez-Bolaños Isabel Sada-Ovalle |
| author_facet | Ranferi Ocaña-Guzman Luis Vázquez-Bolaños Isabel Sada-Ovalle |
| author_sort | Ranferi Ocaña-Guzman |
| collection | DOAJ |
| description | A variety of receptors perform the function of attenuating or inhibiting activation of cells in which they are expressed. Examples of these kinds of receptors include TIM-3 and PD-1, among others that have been widely studied in cells of lymphoid origin and, though to a lesser degree, in other cell lines. Today, several studies describe the function of these molecules as part of the diverse mechanisms of immune tolerance that exist in the immune system. This review analyzes the function of some of these proteins in monocytes and macrophages and as well as their participation as inhibitory molecules or elements of immunological tolerance that also act in innate defense mechanisms. We chose the receptors TIM-3, PD-1, CD32b, and CD200R because these molecules have distinct functional characteristics that provide examples of the different regulating mechanisms in monocytes and macrophages. |
| format | Article |
| id | doaj-art-b01da4a92c7a4beebefb06a9c00347ce |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b01da4a92c7a4beebefb06a9c00347ce2025-02-03T05:47:41ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/86951578695157Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and ToleranceRanferi Ocaña-Guzman0Luis Vázquez-Bolaños1Isabel Sada-Ovalle2Laboratorio de Inmunología Integrativa, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México, MexicoLaboratorio de Inmunología Integrativa, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México, MexicoLaboratorio de Inmunología Integrativa, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Ciudad de México, MexicoA variety of receptors perform the function of attenuating or inhibiting activation of cells in which they are expressed. Examples of these kinds of receptors include TIM-3 and PD-1, among others that have been widely studied in cells of lymphoid origin and, though to a lesser degree, in other cell lines. Today, several studies describe the function of these molecules as part of the diverse mechanisms of immune tolerance that exist in the immune system. This review analyzes the function of some of these proteins in monocytes and macrophages and as well as their participation as inhibitory molecules or elements of immunological tolerance that also act in innate defense mechanisms. We chose the receptors TIM-3, PD-1, CD32b, and CD200R because these molecules have distinct functional characteristics that provide examples of the different regulating mechanisms in monocytes and macrophages.http://dx.doi.org/10.1155/2018/8695157 |
| spellingShingle | Ranferi Ocaña-Guzman Luis Vázquez-Bolaños Isabel Sada-Ovalle Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance Journal of Immunology Research |
| title | Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance |
| title_full | Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance |
| title_fullStr | Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance |
| title_full_unstemmed | Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance |
| title_short | Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance |
| title_sort | receptors that inhibit macrophage activation mechanisms and signals of regulation and tolerance |
| url | http://dx.doi.org/10.1155/2018/8695157 |
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