Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays
Chemical-nose/tongue technologies are emerging as promising analytical tools for glycan analysis. After briefly introducing the importance of glycans and their analytical methods, including the lectin microarray (LMA) as one of the gold standards, the fundamental principles underlying chemical noses...
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Elsevier
2025-01-01
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| Series: | BBA Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667160324000176 |
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| author | Shunsuke Tomita Chiaki Nagai-Okatani |
| author_facet | Shunsuke Tomita Chiaki Nagai-Okatani |
| author_sort | Shunsuke Tomita |
| collection | DOAJ |
| description | Chemical-nose/tongue technologies are emerging as promising analytical tools for glycan analysis. After briefly introducing the importance of glycans and their analytical methods, including the lectin microarray (LMA) as one of the gold standards, the fundamental principles underlying chemical noses/tongues are explained and various applications for monosaccharides and glycans are introduced. Then, the similarities and differences of these two approaches are discussed. While both technologies aim to comprehensively profile biospecimens based on ‘interaction patterns’ between multiple recognition probes and analytes, each has its own strengths. LMAs excel at specific, targeted analysis based on defined lectin–glycan interactions, whereas chemical nose/tongue offers greater flexibility and expandability in terms of system design, making it well-suited for discovering unknown glycan profiles and detecting broader differences in glycan mixtures. In the future, chemical-nose/tongue technologies may be applied to niche areas in glycan analysis and become powerful tools that complement LMA techniques. |
| format | Article |
| id | doaj-art-b0127b97a88e4c2ab5e22a934a15e580 |
| institution | Kabale University |
| issn | 2667-1603 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | BBA Advances |
| spelling | doaj-art-b0127b97a88e4c2ab5e22a934a15e5802024-12-17T05:01:46ZengElsevierBBA Advances2667-16032025-01-017100129Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarraysShunsuke Tomita0Chiaki Nagai-Okatani1Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan; School of Integrative and Global Majors, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan; Corresponding author at: Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan.Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8565, Japan; Corresponding author at: Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8565, Japan.Chemical-nose/tongue technologies are emerging as promising analytical tools for glycan analysis. After briefly introducing the importance of glycans and their analytical methods, including the lectin microarray (LMA) as one of the gold standards, the fundamental principles underlying chemical noses/tongues are explained and various applications for monosaccharides and glycans are introduced. Then, the similarities and differences of these two approaches are discussed. While both technologies aim to comprehensively profile biospecimens based on ‘interaction patterns’ between multiple recognition probes and analytes, each has its own strengths. LMAs excel at specific, targeted analysis based on defined lectin–glycan interactions, whereas chemical nose/tongue offers greater flexibility and expandability in terms of system design, making it well-suited for discovering unknown glycan profiles and detecting broader differences in glycan mixtures. In the future, chemical-nose/tongue technologies may be applied to niche areas in glycan analysis and become powerful tools that complement LMA techniques.http://www.sciencedirect.com/science/article/pii/S2667160324000176SaccharidesGlycansOptical biosensingLectin microarraysMultivariate analysisMachine learning |
| spellingShingle | Shunsuke Tomita Chiaki Nagai-Okatani Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays BBA Advances Saccharides Glycans Optical biosensing Lectin microarrays Multivariate analysis Machine learning |
| title | Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays |
| title_full | Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays |
| title_fullStr | Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays |
| title_full_unstemmed | Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays |
| title_short | Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays |
| title_sort | expanding the recognition of monosaccharides and glycans a comprehensive analytical approach using chemical nose tongue technology and a comparison to lectin microarrays |
| topic | Saccharides Glycans Optical biosensing Lectin microarrays Multivariate analysis Machine learning |
| url | http://www.sciencedirect.com/science/article/pii/S2667160324000176 |
| work_keys_str_mv | AT shunsuketomita expandingtherecognitionofmonosaccharidesandglycansacomprehensiveanalyticalapproachusingchemicalnosetonguetechnologyandacomparisontolectinmicroarrays AT chiakinagaiokatani expandingtherecognitionofmonosaccharidesandglycansacomprehensiveanalyticalapproachusingchemicalnosetonguetechnologyandacomparisontolectinmicroarrays |