Effect of acupuncture on the gait disturbance and hemodynamic changes in the prefrontal cortex: a study protocol for a randomized controlled trial
BackgroundAlzheimer’s disease (AD) is characterized by cognitive impairment and behavioral impairment. The gait of AD patients is attracting the increasing attention. The aim of this randomized controlled trial (RCT) is to explore the effect of acupuncture on the cognitive function, gait performance...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1444873/full |
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| author | Zhenmei Hong Shuijing Zhang Shuqing Zhang Yuqi Zhao Xiancong Ye Xinxin Shu Yufan Chen Shuding Yan Ruijie Ma |
| author_facet | Zhenmei Hong Shuijing Zhang Shuqing Zhang Yuqi Zhao Xiancong Ye Xinxin Shu Yufan Chen Shuding Yan Ruijie Ma |
| author_sort | Zhenmei Hong |
| collection | DOAJ |
| description | BackgroundAlzheimer’s disease (AD) is characterized by cognitive impairment and behavioral impairment. The gait of AD patients is attracting the increasing attention. The aim of this randomized controlled trial (RCT) is to explore the effect of acupuncture on the cognitive function, gait performance, and hemodynamic changes in the prefrontal cortices.MethodsIn this RCT, a total of 108 AD patients will be randomly assigned into acupuncture group or control group for 8 weeks. The primary outcome will be three-dimensional gait analysis and cerebral hemodynamics using functional near-infrared spectroscopy (fNIRS). Secondary outcomes will include Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Barthel Index (BI).DiscussionThis trial is expected to explore the effect of acupuncture on cognitive function, gait performance, and hemodynamic changes in the prefrontal cortices for AD patients. |
| format | Article |
| id | doaj-art-afd8c80df5d04a95ad77050e2aca42d9 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-afd8c80df5d04a95ad77050e2aca42d92025-01-15T18:08:23ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011510.3389/fneur.2024.14448731444873Effect of acupuncture on the gait disturbance and hemodynamic changes in the prefrontal cortex: a study protocol for a randomized controlled trialZhenmei Hong0Shuijing Zhang1Shuqing Zhang2Yuqi Zhao3Xiancong Ye4Xinxin Shu5Yufan Chen6Shuding Yan7Ruijie Ma8Department of Neurology, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, ChinaDepartment of Rehabilitation, Zhejiang Rehabilitation Medical Center, Hangzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, ChinaDepartment of Rehabilitation, Zhejiang Rehabilitation Medical Center, Hangzhou, ChinaDepartment of Center for Rehabilitation Assessment and Therapy, Zhejiang Rehabilitation Medical Center, Hangzhou, ChinaDepartment of Center for Rehabilitation Assessment and Therapy, Zhejiang Rehabilitation Medical Center, Hangzhou, ChinaThe Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaThe Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, ChinaBackgroundAlzheimer’s disease (AD) is characterized by cognitive impairment and behavioral impairment. The gait of AD patients is attracting the increasing attention. The aim of this randomized controlled trial (RCT) is to explore the effect of acupuncture on the cognitive function, gait performance, and hemodynamic changes in the prefrontal cortices.MethodsIn this RCT, a total of 108 AD patients will be randomly assigned into acupuncture group or control group for 8 weeks. The primary outcome will be three-dimensional gait analysis and cerebral hemodynamics using functional near-infrared spectroscopy (fNIRS). Secondary outcomes will include Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Barthel Index (BI).DiscussionThis trial is expected to explore the effect of acupuncture on cognitive function, gait performance, and hemodynamic changes in the prefrontal cortices for AD patients.https://www.frontiersin.org/articles/10.3389/fneur.2024.1444873/fullacupuncturegait disturbanceAlzheimer’s diseasestudy protocolrandomized controlled trial |
| spellingShingle | Zhenmei Hong Shuijing Zhang Shuqing Zhang Yuqi Zhao Xiancong Ye Xinxin Shu Yufan Chen Shuding Yan Ruijie Ma Effect of acupuncture on the gait disturbance and hemodynamic changes in the prefrontal cortex: a study protocol for a randomized controlled trial Frontiers in Neurology acupuncture gait disturbance Alzheimer’s disease study protocol randomized controlled trial |
| title | Effect of acupuncture on the gait disturbance and hemodynamic changes in the prefrontal cortex: a study protocol for a randomized controlled trial |
| title_full | Effect of acupuncture on the gait disturbance and hemodynamic changes in the prefrontal cortex: a study protocol for a randomized controlled trial |
| title_fullStr | Effect of acupuncture on the gait disturbance and hemodynamic changes in the prefrontal cortex: a study protocol for a randomized controlled trial |
| title_full_unstemmed | Effect of acupuncture on the gait disturbance and hemodynamic changes in the prefrontal cortex: a study protocol for a randomized controlled trial |
| title_short | Effect of acupuncture on the gait disturbance and hemodynamic changes in the prefrontal cortex: a study protocol for a randomized controlled trial |
| title_sort | effect of acupuncture on the gait disturbance and hemodynamic changes in the prefrontal cortex a study protocol for a randomized controlled trial |
| topic | acupuncture gait disturbance Alzheimer’s disease study protocol randomized controlled trial |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1444873/full |
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