Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS

Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS

Summary: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease causing progressive paralysis due to motor neuron degeneration with no curative therapy despite extensive biomedical research. One of the primary targets of ALS is skeletal muscle, which undergoes profound functional c...

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Main Authors: Veronica Ruggieri, Silvia Scaricamazza, Andrea Bracaglia, Chiara D’Ercole, Cristina Parisi, Paolo D’Angelo, Daisy Proietti, Chiara Cappelletti, Alberto Macone, Biliana Lozanoska-Ochser, Marina Bouchè, Lucia Latella, Cristiana Valle, Alberto Ferri, Lorenzo Giordani, Luca Madaro
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Metabolism
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724014748
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