Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides

Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides

Background The individual HLA-I genotype is associated with cancer, autoimmune diseases and infections. This study elucidates the role of germline homozygosity or allelic imbalance of HLA-I loci in esophago-gastric adenocarcinoma (EGA) and determines the resulting repertoires of potentially immunoge...

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Main Authors: Alexander Quaas, Julie George, Philipp Müller, Hans Anton Schlößer, Michael von Bergwelt-Baildon, Martin Thelen, Birgit Gathof, Martin Peifer, Thomas Zander, Axel M Hillmer, Christiane Bruns, Diandra Keller, Jonas Lehmann, Kerstin Wennhold, Eugen Bauer, Maria Alejandra Garcia-Marquez, Roman Thomas, Lukas Maas, Miloš Nikolić, Wolfgang Schröder, Ali M Yazbeck
Format: Article
Language:English
Published: BMJ Publishing Group 2024-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/4/e007268.full
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